Neuroprotective effects of goji berry (Lycium barbarum L.) polysaccharides on depression-like behavior in ovariectomized rats: Behavioral and biochemical evidence

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dc.authorid0000-0002-0000-3768en_US
dc.authorid0000-0001-5245-6294en_US
dc.authorid0000-0025-5098-7177en_US
dc.authorid0000-0002-8317-7092en_US
dc.contributor.authorSoytürk, Hayriye
dc.contributor.authorBozat, Bihter Gökçe
dc.contributor.authorKarakaş, Fatma Pehlivan
dc.contributor.authorCoşkun, Hamit
dc.contributor.authorFırat, Tülin
dc.date.accessioned2024-05-06T08:24:42Z
dc.date.available2024-05-06T08:24:42Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Ziraat Fakültesi, Kanatlı Hayvan Yetiştiriciliği Bölümüen_US
dc.descriptionFunding This study was financed by the Bolu Abant Izzet Baysal Universi-ty Research Foundation (Project No: 2016.10.07.956) . Authors declare that the funding source had no influence on the study design, interpretation of the results, writing of the manuscript, or the decision to submit the manu-script.en_US
dc.description.abstractAim To assess the protective effects of goji berry (Lycium barbarum L.) polysaccharides (LBP) on depression-like behavior in ovariectomized rats and to elucidate the mechanisms underlying these effects. Methods One hundred female Wistar albino rats (three months old) were randomly assigned either to ovariectomy (n = 50) or sham surgery (n = 50). After a 14-day recovery period, the groups were divided into five treatment subgroups (10 per group): high-dose LBP (200 mg/kg), low-dose LBP (20 mg/kg), imipramine (IMP, 2.5 mg/kg), 17 beta estradiol (E2, 1 mg/kg), and distilled water. Then, rats underwent a forced swimming test. We also determined the levels of serum antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, and malondialdehyde), E2 levels, hippocampal brain-derived neurotrophic factor (BDNF), 5HT2A receptor, and transferase dUTP nick end labeling (TUNEL)-positive cells. Results Both low-dose LBP and imipramine decreased depression-like behavior by increasing serum superoxide dismutase activity and by decreasing serum malondialdehyde level. Furthermore, low-dose LPB, high-dose LBP, and imipramine increased the number of 5-HT2A receptor-and BDNF-positive cells but decreased the number of TUNELpositive cells in the hippocampus. Conclusion This is the first study to show the antidepressant effect of LBP. Although additional research is needed, LBP may be considered a potential new antidepressant.en_US
dc.description.sponsorshipBolu Abant Izzet Baysal Universi-ty Research Foundation [2016.10.07.956]en_US
dc.identifier.citationSoytürk, H., Bozat, B. G., Karakas, F. P., Coskun, H., & Firat, T. (2023). Neuroprotective effects of goji berry (Lycium barbarum L.) polysaccharides on depression-like behavior in ovariectomized rats: behavioral and biochemical evidence. Croatian Medical Journal, 64(4), 231.en_US
dc.identifier.doi10.3325/cmj.2023.64.231
dc.identifier.endpage242en_US
dc.identifier.issn0353-9504
dc.identifier.issn1332-8166
dc.identifier.issue4en_US
dc.identifier.pmid37654035en_US
dc.identifier.scopus2-s2.0-85169369319en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage231en_US
dc.identifier.urihttp://dx.doi.org/10.3325/cmj.2023.64.231
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12118
dc.identifier.volume64en_US
dc.identifier.wosWOS:001077802000003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSoytürk, Hayriye
dc.institutionauthorKarakaş, Fatma Pehlivan
dc.institutionauthorCoşkun, Hamit
dc.institutionauthorFırat, Tülin
dc.language.isoenen_US
dc.publisherMedicinska Nakladaen_US
dc.relation.ispartofCroatian Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOxidative Stressen_US
dc.subjectCell-Proliferationen_US
dc.subjectSerotoninen_US
dc.subjectHippocampusen_US
dc.subjectAnxietyen_US
dc.subjectMooden_US
dc.titleNeuroprotective effects of goji berry (Lycium barbarum L.) polysaccharides on depression-like behavior in ovariectomized rats: Behavioral and biochemical evidenceen_US
dc.typeArticleen_US

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