Neuroprotective effects of goji berry (Lycium barbarum L.) polysaccharides on depression-like behavior in ovariectomized rats: Behavioral and biochemical evidence
Yükleniyor...
Dosyalar
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Medicinska Naklada
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim To assess the protective effects of goji berry (Lycium barbarum L.) polysaccharides (LBP) on depression-like behavior in ovariectomized rats and to elucidate the mechanisms underlying these effects. Methods One hundred female Wistar albino rats (three months old) were randomly assigned either to ovariectomy (n = 50) or sham surgery (n = 50). After a 14-day recovery period, the groups were divided into five treatment subgroups (10 per group): high-dose LBP (200 mg/kg), low-dose LBP (20 mg/kg), imipramine (IMP, 2.5 mg/kg), 17 beta estradiol (E2, 1 mg/kg), and distilled water. Then, rats underwent a forced swimming test. We also determined the levels of serum antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, and malondialdehyde), E2 levels, hippocampal brain-derived neurotrophic factor (BDNF), 5HT2A receptor, and transferase dUTP nick end labeling (TUNEL)-positive cells. Results Both low-dose LBP and imipramine decreased depression-like behavior by increasing serum superoxide dismutase activity and by decreasing serum malondialdehyde level. Furthermore, low-dose LPB, high-dose LBP, and imipramine increased the number of 5-HT2A receptor-and BDNF-positive cells but decreased the number of TUNELpositive cells in the hippocampus. Conclusion This is the first study to show the antidepressant effect of LBP. Although additional research is needed, LBP may be considered a potential new antidepressant.
Açıklama
Funding This study was financed by the Bolu Abant Izzet Baysal Universi-ty Research Foundation (Project No: 2016.10.07.956) . Authors declare that the funding source had no influence on the study design, interpretation of the results, writing of the manuscript, or the decision to submit the manu-script.
Anahtar Kelimeler
Oxidative Stress, Cell-Proliferation, Serotonin, Hippocampus, Anxiety, Mood
Kaynak
Croatian Medical Journal
WoS Q Değeri
Q2
Scopus Q Değeri
Q3
Cilt
64
Sayı
4
Künye
Soytürk, H., Bozat, B. G., Karakas, F. P., Coskun, H., & Firat, T. (2023). Neuroprotective effects of goji berry (Lycium barbarum L.) polysaccharides on depression-like behavior in ovariectomized rats: behavioral and biochemical evidence. Croatian Medical Journal, 64(4), 231.
