Activation of TRESK background potassium channels by cloxyquin exerts protective effects against excitotoxic-induced brain injury and neuroinflammation in neonatal rats

dc.authorid0000-0002-3802-0336en_US
dc.authorid0000-0002-1795-5677en_US
dc.authorid0000-0001-9261-2634en_US
dc.authorid0000-0001-7035-3336en_US
dc.authorid0000-0002-1065-3254en_US
dc.authorid0000-0001-6768-1275en_US
dc.contributor.authorDilek, Mustafa
dc.contributor.authorKılınç, Yasemin Baranoğlu
dc.contributor.authorKılınç, Erkan
dc.contributor.authorTorun, İbrahim Ethem
dc.contributor.authorSaylan, Aslıhan
dc.contributor.authorDüzcü, Selma Erdoğan
dc.date.accessioned2024-03-14T10:58:37Z
dc.date.available2024-03-14T10:58:37Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionThis study was supported by Bolu Abant Izzet Baysal University Scientific Research Fund (Grant-number: 2019.08.23.1433).en_US
dc.description19th Turkish Neuroscience Congress
dc.description.abstractWe investigated effects of activation of TRESK channels by selective activator cloxyquin on excitotoxic-induced brain injury and neuroinflammation involving brain mast cells and inflammatory cytokines in neonatal rats. Three different doses of cloxyquin (0.2, 1 and 5 mg/kg) were studied in ibotenate-induced perinatal brain injury (PBI) in P5 rat-pups. Cerebral lesions and mast cells in coronal brain sections were evaluated. Concentrations of activin A, IL-1 beta, IL-6 and IL-10 in brain homogenates were measured using ELISA. Cloxyquin dose-dependently exerted protective effects against excitotoxic-induced neonatal brain injury and neuroinflammation. TRESK channels may be a promising new target for the treatment of PBIs.en_US
dc.description.sponsorshipBolu Abant Izzet Baysal University Scientific Research Fund [2019.08.23.1433]en_US
dc.identifier.citationDilek, M., Kilinc, Y. B., Kilinc, E., Torun, I. E., Saylan, A., & Duzcu, S. E. (2022). Activation of TRESK background potassium channels by cloxyquin exerts protective effects against excitotoxic-induced brain injury and neuroinflammation in neonatal rats. Journal of Neuroimmunology, 368, 577894.en_US
dc.identifier.doi10.1016/j.jneuroim.2022.577894
dc.identifier.endpage10en_US
dc.identifier.issn0165-5728
dc.identifier.issn1872-8421
dc.identifier.pmid35642994en_US
dc.identifier.scopus2-s2.0-85130530778en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.jneuroim.2022.577894
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12088
dc.identifier.volume368en_US
dc.identifier.wosWOS:000866081500002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDilek, Mustafa
dc.institutionauthorKılınç, Yasemin Baranoğlu
dc.institutionauthorKılınç, Erkan
dc.institutionauthorTorun, İbrahim Ethem
dc.institutionauthorSaylan, Aslıhan
dc.institutionauthorDüzcü, Selma Erdoğan
dc.language.isoenen_US
dc.publisherElseiveren_US
dc.relation.ispartofJournal of Neuroimmunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectExcitotoxicityen_US
dc.subjectBrain mast cellsen_US
dc.subjectNeuroinflammationen_US
dc.subjectMast-Cellsen_US
dc.subjectEarly Respondersen_US
dc.subjectActivin-Aen_US
dc.titleActivation of TRESK background potassium channels by cloxyquin exerts protective effects against excitotoxic-induced brain injury and neuroinflammation in neonatal ratsen_US
dc.typeArticleen_US

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