Activation of TRESK background potassium channels by cloxyquin exerts protective effects against excitotoxic-induced brain injury and neuroinflammation in neonatal rats
dc.authorid | 0000-0002-3802-0336 | en_US |
dc.authorid | 0000-0002-1795-5677 | en_US |
dc.authorid | 0000-0001-9261-2634 | en_US |
dc.authorid | 0000-0001-7035-3336 | en_US |
dc.authorid | 0000-0002-1065-3254 | en_US |
dc.authorid | 0000-0001-6768-1275 | en_US |
dc.contributor.author | Dilek, Mustafa | |
dc.contributor.author | Kılınç, Yasemin Baranoğlu | |
dc.contributor.author | Kılınç, Erkan | |
dc.contributor.author | Torun, İbrahim Ethem | |
dc.contributor.author | Saylan, Aslıhan | |
dc.contributor.author | Düzcü, Selma Erdoğan | |
dc.date.accessioned | 2024-03-14T10:58:37Z | |
dc.date.available | 2024-03-14T10:58:37Z | |
dc.date.issued | 2022 | en_US |
dc.department | BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.description | This study was supported by Bolu Abant Izzet Baysal University Scientific Research Fund (Grant-number: 2019.08.23.1433). | en_US |
dc.description | 19th Turkish Neuroscience Congress | |
dc.description.abstract | We investigated effects of activation of TRESK channels by selective activator cloxyquin on excitotoxic-induced brain injury and neuroinflammation involving brain mast cells and inflammatory cytokines in neonatal rats. Three different doses of cloxyquin (0.2, 1 and 5 mg/kg) were studied in ibotenate-induced perinatal brain injury (PBI) in P5 rat-pups. Cerebral lesions and mast cells in coronal brain sections were evaluated. Concentrations of activin A, IL-1 beta, IL-6 and IL-10 in brain homogenates were measured using ELISA. Cloxyquin dose-dependently exerted protective effects against excitotoxic-induced neonatal brain injury and neuroinflammation. TRESK channels may be a promising new target for the treatment of PBIs. | en_US |
dc.description.sponsorship | Bolu Abant Izzet Baysal University Scientific Research Fund [2019.08.23.1433] | en_US |
dc.identifier.citation | Dilek, M., Kilinc, Y. B., Kilinc, E., Torun, I. E., Saylan, A., & Duzcu, S. E. (2022). Activation of TRESK background potassium channels by cloxyquin exerts protective effects against excitotoxic-induced brain injury and neuroinflammation in neonatal rats. Journal of Neuroimmunology, 368, 577894. | en_US |
dc.identifier.doi | 10.1016/j.jneuroim.2022.577894 | |
dc.identifier.endpage | 10 | en_US |
dc.identifier.issn | 0165-5728 | |
dc.identifier.issn | 1872-8421 | |
dc.identifier.pmid | 35642994 | en_US |
dc.identifier.scopus | 2-s2.0-85130530778 | en_US |
dc.identifier.scopusquality | Q2 | en_US |
dc.identifier.startpage | 1 | en_US |
dc.identifier.uri | http://dx.doi.org/10.1016/j.jneuroim.2022.577894 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12491/12088 | |
dc.identifier.volume | 368 | en_US |
dc.identifier.wos | WOS:000866081500002 | en_US |
dc.identifier.wosquality | Q3 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.institutionauthor | Dilek, Mustafa | |
dc.institutionauthor | Kılınç, Yasemin Baranoğlu | |
dc.institutionauthor | Kılınç, Erkan | |
dc.institutionauthor | Torun, İbrahim Ethem | |
dc.institutionauthor | Saylan, Aslıhan | |
dc.institutionauthor | Düzcü, Selma Erdoğan | |
dc.language.iso | en | en_US |
dc.publisher | Elseiver | en_US |
dc.relation.ispartof | Journal of Neuroimmunology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Excitotoxicity | en_US |
dc.subject | Brain mast cells | en_US |
dc.subject | Neuroinflammation | en_US |
dc.subject | Mast-Cells | en_US |
dc.subject | Early Responders | en_US |
dc.subject | Activin-A | en_US |
dc.title | Activation of TRESK background potassium channels by cloxyquin exerts protective effects against excitotoxic-induced brain injury and neuroinflammation in neonatal rats | en_US |
dc.type | Article | en_US |