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Öğe Akut miyokard enfarktüsü sonrası gelişen geniş ventriküler septal rüptürün başarılı tedavisi(Aves, 2007) Kaya, Ahmet; Kaya, Yasemin; Ordu, Serkan; Özkökeli, Mehmet; Özhan, Hakan; Dağlar, Bahadır; Yazıcı, MehmetPostinfarct ventricular septal rupture (VSR) is a rare but mortal complication of acute myocardial infarction (MI). VSR must be diagnosed earlier and the correct treatment must be applied immediately. Abrupt surgical repair is the choice of treatment, which decreases early mortality and improves long term survival. Septal rupture occurs more frequently with anterior than with other types of acute myocardial infarction. VSR occurs usually within 2 weeks after infraction. We describe here a 76-year-old woman with a giant VSR with little hemodynamic disturbance that developed twenty days after anterior myocardial infarction. She was successfully treated with abrupt surgical closure.Öğe Evaluation and comparison of optical coherence tomography angiography (OCTA) parameters in normal and moderate myopic individuals(Elsevier, 2024) Toprak, Güvenç; Ulaş, Fatih; Kaymaz, Abdulgani; Soydan, Adem; Kaplan, Abdulfatih; Alkan, Yunus; Özdemir, Buse; Bayrak, AbdullahObjective: The objective of this study was to evaluate and compare Optical Coherence Tomography Angiography (OCTA) parameters in patients with moderate myopia and healthy individuals retrospectively. Methods: A total of 80 male individuals aged 18-20 years were included in the study with 40 moderate myopic and 40 healthy persons. All participants underwent detailed ocular examination including refraction, intraocular pressure (IOP), visual acuity, biomicroscopy, OCTA measurement and optic biometry measurement. Retinal, retinal nerve fiber layer and choroidal layer thicknesses were evaluated in mu m with the help of the software available in the OCTA device. Results: The mean axial length (24.32 +/- 0.53 mm) was statistically significantly higher in the moderate myopic group (24.32 mm) compared to the healthy group (23.33 +/- 0.61 mm) (p < 0.001). Spherical equivalent (SE) was found as -3.79 +/- 0.91 D in the moderate myopic group and -0.22 +/- 0.32 D in the healthy group (p < 0.05). The mean superficial foveal mean density (FovSupMVD) and the mean deep foveal mean density (FovDepMVD) were statistically significantly lower in the moderate myopic group than in the healthy group (both, p < 0.001). The mean retinal temporal thickness (RTt) was statistically significantly lower in the moderate myopic group (p = 0.017). There was a mild negative correlation between axial length and FovSupMVD, FovDepMVD in myopes. In axial length ROC analysis, the cutoff value for moderate myopes was found to be 24.15 mm. Mean superficial foveal mean density (FovSupMVD) and mean deep foveal mean density (FovDepMVD), mean retinal temporal thickness (RTt) were significantly lower in the group above 24.15 mm axial length compared to the group below 24.15 mm axial length (all three, p < 0.001). Foveal avascular zone was significantly higher in the group above 24.15 mm axial length (p = 0.016) Conclusion: The results of our study indicate that the mean axial length and spherical equivalent were significantly higher, while retinal temporal thickness, the mean superficial foveal mean density and the mean deep foveal mean density were significantly lower in patients with myopia up to -6.0 D compared to the healthy individuals.Öğe Effects of modulation of certain TRP channels and voltage-gated potassium channel activities on calcitonin gene- related peptide release in isolated rat hemiskull preparations(Karger, 2021) Çıtak, Arzu; Kılınç, Erkan; Ankaralı, Seyit; Dağıstan, Yaşar; Yoldaş, HamitÖğe Doğum sonu kanamayı önlemede rektal misoprostol ve intravenöz oksitosinin etkinliklerinin karşılaştırılması(Galenos Yayincilik, 2006) Gül, Özlem Kemik; Somunkıran, Aslı; Özdemir, İsmail; Yücel, Oğuz; Demirci, FuatObjective: To compare the effectiveness of rectally administered prostaglandine E1 anolog misoprostol and parenterally oxytocin for the prevention of postpartum hemorrhage. Design: Prospective randomized trial Setting: University hospital Patients: 240 full term pregnant women who were in active labor. Interventions: 80 patients in group 1 received 200 mu g misoprostol rectally, 80 patients in Group 2 received 400 mu g rectally misoprostol, and the third group received a solution of 1000 ml 5% DRL + 10 IU oxytocin, immediately after the delivery of the fetus. Main outcome measures: Postpartum blood loss and potential side effects of misoprostol were evaluated. Results: No statistically significant difference was found among the three groups regarding the average blood loss (F=1.50, p=0.22). Average duration of the third stage of labor was similar in all groups (F=1.13, p=0.32). Hematocrit values were similar in the groups both before (F=3.28, p=0.52) and after the delivery and (F=1.84, p=0.16). Conclusions: No differences were found between rectallymisoprostol and oxytocin treatment for the prevention of postpartum hemorrhage. Nevertheless, misoprostol can be preferred in the prevention of postpartum hemorrhage because it does not require special storage conditions, can be used safely in hypertensive patients, can be stored for many years, it is resistant to heat and its side effects such as nausea and vomiting are low when used rectally.Öğe Effect of Urtica Dioica on bacterial translocation in mechanic icter model(2006) Aydın, Metin; Özaydın, İsmet; İlçe, Zekeriya; Şahin, İdris; Şencan, İrfan; Sılan, Coşkun; Yaşar, MehmetSepsis and renal, hepatic and multi organ failure syndrome, due to bacterial translocation, if the operations were carried out for mechanic icter, still cause high morbidity and mortality.1 It is known that obstructions of the extra hepatic bile ducts increase the translocation of bacteria in the gastrointestinal system. It was reported that bacterial translocation causes sepsis and multiple organ failure syndrome.2 Urtica Dioica (UD) is a perennial plant with stinging hairs belonging to the plant family Urticaceae with a height of 30-100 cm. It is endemic in many parts of Turkey, and seeds have been widely used in folk medicine, particularly in advanced cancer patients, for a long time.3 In some studies, an anti proliferative effect in prostate cancer, an anti inflammatory effect in chronic inflammatory events such as rheumatoid arthritis, a mitogenic effect on the T lymphocytes, and an antidiuretic and hypotensive effect has been reported.4 It was also reported that UD prevents the toxic effect of carbon tetrachloride on the liver.3 The aim of the present study was to investigate the efficiency of UD on bacterial translocation in an experimental model.Öğe Mean platelet volume in nasal polyps.(2013) Aktaş, Gülali; Şit, Mustafa; Tekçe, Hikmet; Alçelik, Aytekin; Şavlı, Haluk; Şimşek, Tuğçe; Özmen, EvrimMany studies in literature point out that inflammation related to nasal polyp is mostly dependent on eosinophils and their inflammatory products. Beside eosinophils, platelets may have a role in nasal polyp development. Platelets are involved in haemostasis, tissue repairing and inflammation. However, to our knowledge, there are no reports in the literature that study the association between platelet parameters and nasal polyps. Forty-three patients with nasal polyps and forty-nine healthy controls were enrolled in the study, retrospectively. Laboratory data of patients with nasal polyp were obtained at the time of diagnosis. There were no statistically significant differences between the two groups in terms of white blood count, haemoglobin, haematocrit and platelet count. The mean platelet volume (MPV) value of the nasal polyp group was significantly lower than the control group (p = 0.025). Mean eosinophil count was significantly elevated in the nasal polyp group compared to the control group (p < 0.001). Reduction in MPV may be an indicator for nasal polyp formation. Further studies with a larger study population are needed to detect the possible correlation between eosinophil count and MPV values in patients with nasal polyps.Öğe Efficacy of aprotinin treatment on bilateral blunt chest trauma created in rab(2013) Kaya, Halil; Kafalı, Mehmet Ertuğrul; Aydın, Kemal; Koçak, Sedat; Şahin, Mustafa; Gül, Mehmet; Cander, BaşarObjectives: To investigate the effects of aprotinin, on blood gasses, oxidant-antioxidant status, and lung histopathology in an experimental bilateral blunt chest trauma model. Methods: Conducted at the Experimental Animal Laboratory of Meram Medical School at Selcuk University, Konya, Turkey, the study comprised 21 New Zealand female albino rabbits who were divided into three groups. Trauma was applied on the sham and aprotinin groups, which was administered intravenous Aprotinin 20.000 U/kg. Arterial blood samples were obtained from all rabbits at hours 0, 3, 24, and 96. At hour 96 after trauma, all rabbits were sacrificed using the decapitation method, and then blood and lung tissue samples were obtained. Blood nitric oxide, malondialdehyde and blood gas measurements were made. Histopathological changes in the lung were examined with a light microscope. Results: While no positive effect of aprotinin was observed on nitric oxide malondialdehyde and partial pressure of carbon dioxide values, it was seen to have an increasing effect on partial oxygen pressure level. Aprotinin had a partial effect on lung histopathology. Conclusion: Aprotinin was determined to have a positive effect on PO2 levels. We could not find any positive effects especially on alveolar haemorrhage.Öğe Giant ossifying fibroma complicated by mucocele of sphenoid sinus - Case report(2008) Gezici, Ali Rıza; Ergün, Behzat RüçhanOssifying fibroma is a benign tumour that rarely involves the skull. It is most commonly seen in the facial bones with a particular predilection for the mandible. It shares many pathological features with fibrous dysplasia. Ossifying fibroma is an expansive lesion and shows larger non-ossified areas of fibrous tissues. When the tumour is located deeply, encasing the optic-carotid complex, surgical removal becomes difficult because of its ossifying nature. Following surgical resection, the recurrence rate is very low. In the present study, a rare case of giant ossifying fibroma of sphenoid bone which had an intracranial extension with a coexistent mucocele is reported.Öğe Tracheal schwannoma mimicking asthma(Taylor and Francis Ltd., 2024) Afşin, Emine; Yakşi, Osman; Önal, Ali Can; Bacaksız, EmreSchwannoma in primary neurogenic tumors of the trachea is an extremely rare disease. A 21-year-old male patient with stridor was followed up with a diagnosis of asthma for two years. While no lesion was observed in the chest X-ray, tracheal schwannoma was diagnosed in the case who underwent tracheotomy due to the lesion obstructing the trachea almost completely on chest CT. The clinical findings of the patient improved ultimately in the postoperative period. We aimed to discuss the approach and follow-up of the disease with our case, although it is rare that schwannoma might be in the differential diagnosis of masses with upper airway obstruction. © 2022 Informa UK Limited, trading as Taylor & Francis Group.Öğe Extradural posterior inferior cerebellar artery [5] (multiple letters)(2000) Ziyal, İbrahim M.; Salas, E.; Rhoton A.L., Jr.; Fine, A.D.; Cardoso, A.[No abstract available]Öğe Reply: Comparison of two anticoagulants for pain associated with platelet-rich plasma injections(Springer, 2023) Karanfil, Ertuğrul; Doğan, Ali; Görgü, MetinWe read the letter titled ''Comparison of Two Anticoagulants for Pain Associated with Platelet-Rich Plasma Injections'' authored by Pensato et al. in Aesthetic Plastic Surgery. The authors emphasized an important point. PRP treatments have a lot of variables; preparation method, application, amount of PRP injections, and content (such as number of platelet concentration, presence of leucocytes, and pH). However, in our study, we focused on the pain of injections. We showed that there is a pain difference by using different anticoagulants during PRP preparation, but we did not investigate for possible reason of this pain difference. The use of different anticoagulants may have caused changes in the content, and these alterations could be responsible for the variation in pain. Researches could be done to investigate the reason and the physiology of this effect. Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.Öğe Brucellar prosthetic aortic valve endocarditis(Elsevier Science Inc, 2023) Gözdaş, Hasan Tahsin; Şahin, Sultan Beste; Uçaroğlu, Erhan RenanTo the Editor: A 56-year-old man was admitted to the cardiology outpatient clinic with a chief complaint of progressive dyspnea. His past medical history was remarkable for diabetes mellitus, essential hypertension, coronary artery disease, and left hemiplegia due to a cerebrovascular event. He also underwent prosthetic aortic valve replacement 16 years ago.Öğe A chemically induced experimental colitis model with a simple combination of acetic acid and trinitrobenzene sulphonic acid(Aves, 2023) Cinpolat, Havva Yasemin; Buğdaycı, Güler; Şengül, Neriman; Astarcı, Hesna MüzeyyenBackground: It was aimed to induce a new experimental colitis model by using acetic acid and trinitrobenzene sulphonic acid together and to investigate the severity of inflammation biochemically and histopathologically in comparison with other models. Methods: Fifty-six Wistar albino male rats were randomly divided into 4 groups as control, acetic acid, trinitrobenzene sulphonic acid, and combined groups, and the animals were sacrificed following the induction of colitis on the third day and on the seventh day. The serum amyloid A and myeloperoxidase were tested in plasma samples, and the tumor necrosis factor-alpha, interleukin 33, and ST2 were assayed in colon tissue samples with enzyme-linked immunosorbent assay in addition to histopathological examination. Results: There were statistically significant differences between the combined and the control groups both on the third day and on the seventh day in all parameters. There was no difference between the acetic acid group on the seventh day and the control groups in biochemical parameters. Conclusions: The acetic acid model forms acute colitis. The combined model is found to be more successful in forming inflammation when compared to other models.Öğe Protective and therapeutic effects of okra seed in acute nontraumatic brain injury(Taylor & Francis Ltd, 2023) Yoldaş, Meyri Arzu; Bekdaş, Mervan; Danış, Ayşegül; Çetinkaya, Ayhan; Düzcü, Selma Erdoğan; Alışık, Murat; Kocabey, Hüseyin; Türel, İdrisAimThe purpose of this study was to examine the protective and therapeutic effects of okra (Abelmoschus esculentus [AE]) seed extract, with its known antioxidant, immunomodulatory, and anti-inflammatory properties, in an acetaminophen (paracetamol, N-acetyl- para-aminophenol)-induced model of hepatotoxicity and subsequent acute non-traumatic brain damage.Material and MethodForty male Wistar rats were randomly divided into five equal groups, control, paracetamol (P), okra seed extract (AE), okra seed extract + paracetamol (P + AE), and okra seed extract + paracetamol + N-acetyl cysteine (NAC) (P + AE + N). AE was administered by oral gavage through a gastric tube at 600 mg/kg/day for seven days. On the eighth day of the procedure, a single 1 g/kg dose of paracetamol and 300 mg/kg NAC were injected via the intraperitoneal route 1.5 h after AE administration. Rat tissue specimens were subsequently subjected to biochemical and histopathological analyses. Levels of markers such as S100 calcium-binding protein B (S100B), neuron-specific enolase (NSE), and matrix membrane metalloproteinase-9 (MMP-9) were investigated from rat serum specimens. Malondialdehyde (MDA) and superoxide dismutase (SOD) were also measured to determine oxidant-antioxidant status.ResultsS100B, NSE, MMP-9, MDA levels, and SOD enzyme activities were examined using biochemical methods. MDA levels were significantly lower in the P + AE group and MMP-9 levels in the AE, P + AE, and P + AE + N groups compared to the P group. Histopathological examination results supported the biochemical findingsConclusionOkra seed extract exhibits a protective and therapeutic effect against non-traumatic brain damage resulting from acute paracetamol intoxication. We think that this benefit of AE derives from its antioxidant property.Öğe A cross-cultural adaptation and validation of the Turkish version of American Orthopaedic Foot and Ankle Society Metatarsophalangeal-Interphalangeal Scale (AOFAS-MTP-IP) for the hallux(Turkish Joint Diseases Foundation, 2023) Kalaycıoğlu, Oya; Ayanoğlu, Tacettin; Yılmaz, Ömer Faruk; Turhan, Mahmut TimurObjectives: In this study, we aimed to translate and culturally adapt the American Orthopaedic Foot and Ankle Society (AOFAS) Hallux Metatarsophalangeal (MTP)-Interphalangeal (IP) scale, which is used for the clinical assessment of patients with hallux valgus (HV), into Turkish and to evaluate its validity and reliability. Patients and methods: Between February 2022 and October 2022, a total of 67 patients (18 males, 49 females; mean age: 51.5 & PLUSMN;15.9 years; range, 18 to 68 years) with HV deformity and able to communicate in Turkish were included. Following the translation of the AOFAS hallux MTP-IP scale into Turkish, its cultural appropriateness was confirmed. Intra-rater and inter-rater reliabilities were assessed by intraclass correlation coefficients (ICCs), using data collected by two orthopedists. Agreement among test-retest evaluations was conducted using the Bland-Altman analysis. The construct validity of the scale was determined by the Manchester-Oxford Foot Questionnaire (MOXFQ) and Short Form Health Survey (SF-36). Content validity was confirmed by the floor/ceiling effects. Results: The Turkish AOFAS hallux MTP-IP had an excellent intra-rater reliability of 0.971. The intra-rater reliability of the pain, function, and alignment subscales ranged from 0.904 to 0.978. The inter-rater reliability was 0.913 for the total score, while ranging from 0.838 to 0.918 for the subscales. The total score of the AOFAS hallux MTP-IP had a high correlation with the physical domains of the MOXFQ and SF-36, while weaker correlations with mental domains were observed. No floor/ceiling effect was observed for the overall Turkish AOFAS hallux MTP-IP. Conclusion: The Turkish translated and culturally adapted AOFAS hallux MTP-IP scale is a valid and reliable measure, ensuring its use in assessing the clinical status of Turkish patients with HV deformity.Öğe Abelmoschus esculentus (L.) Moench seed extract alleviates acute acetaminophen induced liver damage in rats(National Institute of Science Communication and Information Resources (NISCAIR), 2023) Kocabey, Hüseyin; Bekdaş, Mervan; Çetinkaya, Ayhan; Düzcü, Selma Erdoğan; Alışık, Murat; Türel, İdrisAcetaminophen (N-acetyl-p-aminophenol, APAP), commonly called the 'paracetamol', is one of the most regularly utilized medicines, particularly in children. When administered at the recommended doses, it is a safe medication. However, oxidative stress and inflammation caused by exposure to toxic doses lead to centrilobular hepatic necrosis. N-acetylcysteine (NAC) is utilized in the therapy, however it has potential adverse effects. On the other hand, it is known that the seeds of the common vegetable Okra, Abelmoschus esculentus (AE), a herbal product, possess antioxidant and anti-inflammatory qualities. In the present study, we explored whether AE can be used as an alternative to standard NAC therapy without any adverse effect in the treatment of acute APAP induced liver injury. Forty male Wistar rats were placed into five groups: Control, AE, APAP, APAP+AE and APAP+AE+NAC groups. Antioxidants such as native thiol and total thiol were found rised in the APAP group by adding AE (p =0.043 and p =0.028, respectively). Anti-inflammatory indicator IL-10 was also found increased, while marker ALT, which is a sign of hepatotoxicity, got decreased (P=0.005 and P <0.001, respectively). Histologically, AE has been shown to improve worsened congestion (P =0.003), cytoplasmic vacuolization (P =0.01), sinusoidal dilatation (P =0.001), Kupffer cell proliferation (P <0.001) and inflammation (P <0.001). These results suggest that the okra seeds may be a potential therapeutic agent for paracetamol induced hepatotoxicity and it can be attributed to the antioxidant and anti-inflammatory properties.Öğe Technical aspects and clinical limitations of sperm DNA fragmentation testing in male infertility a global survey, current guidelines, and expert recommendations(Korean Soc Sexual Medicine & Andrology, 2024) Söğütdelen, Emrullah; Agarwal, Ashok; Farkouh, Ala'a; Saleh, Ramadan; Hamoda, Taha Abo-Almagd Abdel-Meguid; Salvio, GianmariaPurpose: Sperm DNA fragmentation (SDF) is a functional sperm abnormality that can impact reproductive potential, for which four assays have been described in the recently published sixth edition of the WHO laboratory manual for the exami-nation and processing of human semen. The purpose of this study was to examine the global practices related to the use of SDF assays and investigate the barriers and limitations that clinicians face in incorporating these tests into their practice. Materials and Methods: Clinicians managing male infertility were invited to complete an online survey on practices related to SDF diagnostic and treatment approaches. Their responses related to the technical aspects of SDF testing, current profes-sional society guidelines, and the literature were used to generate expert recommendations via the Delphi method. Finally, challenges related to SDF that the clinicians encounter in their daily practice were captured. Results: The survey was completed by 436 reproductive clinicians. Overall, terminal deoxynucleotidyl transferase deoxyuri-dine triphosphate Nick-End Labeling (TUNEL) is the most commonly used assay chosen by 28.6%, followed by the sperm chromatin structure assay (24.1%), and the sperm chromatin dispersion (19.1%). The choice of the assay was largely in-fluenced by availability (70% of respondents). A threshold of 30% was the most selected cut-off value for elevated SDF by 33.7% of clinicians. Of respondents, 53.6% recommend SDF testing after 3 to 5 days of abstinence. Although 75.3% believe SDF testing can provide an explanation for many unknown causes of infertility, the main limiting factors selected by respon-dents are a lack of professional society guideline recommendations (62.7%) and an absence of globally accepted references for SDF interpretation (50.3%). Conclusions: This study represents the largest global survey on the technical aspects of SDF testing as well as the barriers en-countered by clinicians. Unified global recommendations regarding clinician implementation and standard laboratory inter-pretation of SDF testing are crucial.Öğe Assessment of intracranial pressure with ultrasonographic measurement of optic nerve sheath diameter on patients undergoing suspension direct laryngoscopy(Springer, 2023) Karalı, Elif; Demirhan, Abdullah; Güneş, Akif; Yıldız, İsa; Ural, AhmetPurpose The study aims to examine the effect on intracranial pressure by calculating the optic nerve sheath diameter (ONSD) using ultrasound in patients who underwent suspension direct laryngoscopy. Methods Thirty-three patients who underwent suspension direct laryngoscopy were included in this prospective observational study. ONSD measurement was performed using a high-frequency linear probe. The ONSD basal (T0) value was determined using ultrasound in the supine position before the induction. Ultrasonography was used to record ONSD in the Boyce Jackson position (T1) just before inserting the laryngeal blade, in the Boyce Jackson position just before removing the laryngeal blade (T2), and in the supine position (T3) just before extubation. Results A statistically significant rise (p < 0.001) was seen between the patients' baseline ONSD values and the values at T1, T2, and T3. The optic nerve sheat diameter level recorded prior to withdrawing the laryngeal blade (T2) was considerably greater than the ONSD level calculated instantly before insertion of the laryngeal blade (T1) (p < 0.001). The ONSD value prior to extubation (T3) following the removal of the laryngeal blade was considerably smaller than the ONSD value prior removing the laryngeal blade (T2) (p < 0.001). Conclusions This study found that when the laryngeal blade is mounted during the suspension direct laryngoscopy surgery, there is a significant increase in ultrasonographically measured ONSD and increased the ONSD even further during the time the mouth gag was remained in situ. This is the first research to indicate that measuring ONSD with ultrasonography during suspension direct laryngoscopy raises intracranial pressure.Öğe Role of the optic nerve sheath diameter in the assessment of the effectiveness of decompressive surgery after malignant middle cerebral artery infarction(Assoc Arquivos Neuro- Psiquiatria, 2022) Şenol, Özgür; Coşgun, Zeliha; Dağıstan, Emine; Demiryürek, Bekir Enes; Cancan, Seçkin EmreBackground After a case of stroke, intracranial pressure (ICP) must be measured and monitored, and the gold standard method for that is through an invasive technique using an intraventricular or intraparenchymal device. However, The ICP can also be assessed through a non-invasive method, comprised of the measurement of the optic nerve sheath diameter (ONSD) through ultrasound (US). Objective To evaluate the ICP of patients who underwent wide decompressive craniectomy after middle cerebral artery (MCA) infarction via preoperative and postoperative ONSD measurements. Methods A total of 17 patients, aged between 34 and 70 years, diagnosed with malignant MCA infarction with radiological edema and mid-line shift, who underwent decompressive surgery, were eligible. From the records, we collected data on age, sex, preoperative and postoperative Glasgow Coma Scale (GCS) scores, National Institutes of Health Stroke Scale (NIHSS) score, the degree of disability in the preoperative period and three months postoperatively through the scores on the Modified Rankin Scale (MRS), and the preoperative and postoperative midline shift measured by computed tomography (CT) scans of the brain. Results Preoperatively, the mean GCS score was of 8 (range: 7.7-9.2), whereas it was found to be of 12 (range 10-14) on the first postoperative day ( p = 0.001). The mean preoperative NIHSS score was of 21.36 +/- 2.70 and, on the first postoperative day, it was of 5.30 +/- 0.75 ( p < 0.001). As for the midline shift, the mean preoperative value was of 1.33 +/- 0.75 cm, and, on the first postoperative day, 0.36 +/- 0.40 cm ( p < 0.001). And, regarding the ONSD, the mean preoperative measurement was of 5.5 +/- 0.1 mm, and, on the first postoperative day, it was of 5 +/- 0.9 mm ( p < 0.001). Conclusion The ocular US measurement of the ONSD for the preoperative and postoperative monitoring of the ICP seems to be a practical and useful method.Öğe Prognostic factors and their effects on mortality in patients with COVID-19 with pneumothorax(Baycınar Medical Publ-Baycnar Tıbbi Yayıncılık, 2022) Yakşi, Osman; Kılıçgün, AliBackground: The aim of this study was to investigate the factors affecting pneumothorax development, lung expansion difficulty, and the impact on mortality in novel coronavirus 2019 (COVID-19) patients. Methods: Between March 2020 and January 2021, a total of 6,108 COVID-19 patients (3,050 males, 3,058 females; mean age: 49 +/- 17.6 years, range, 12 to 89 years) who presented to our hospital were retrospectively analyzed. The patients were divided into two groups. Group 1 (the COVID-19-pneumothorax group) consisted of patients developing pneumothorax while under treatment for COVID-19. Group 2 (COVID-19-without pneumothorax group) consisted of consecutive patients with pulmonary involvement during the same period, requiring intensive care, but not developing pneumothorax. Biochemical test results were examined for the day of hospitalization, day of transfer to intensive care unit, and Day 5 of intensive care unit stay. Lung parenchyma involvement rates on thoracic computed tomography, duration of drainage, duration of intensive care unit stay, and morbidity/mortality data were investigated. Results: Of all patients with COVID-19, 2,342 were admitted to our clinic and 460 needed intensive care. Pneumothorax developed in 21 patients (0.34% of all patients and 0.9% of hospitalized patients). Significant involvement diffusion on computed tomography, ferritin and D-dimer elevation, and low lymphocyte (%) values were observed in the COVID-19 patients with pneumothorax. Pneumothorax development, and ferritin and D-dimer elevation were most correlated with mortality at regression analysis. There was a significant difference in difficulty in lung expansion between COVID-19 patients who developed pneumothorax and who did not. Conclusion: Pneumothorax may develop in COVID-19 patients whose biochemical parameters worsen, and expansion difficulty may be experienced, which is likely to be associated with mortality.
