Cerrahi Tıp Bilimleri Bölümü Koleksiyonu

Bu koleksiyon için kalıcı URI

https://hdl.handle.net/20.500.12491/164

Listeleniyor 1 - 20 / 1612

Traumatic dissecting aneurysm of superficial temporal artery: A case report
(Derman Medical Publ, 2014) Gezici, Ali Rıza; Dağıstan, Yaşar; Güler, Kamil; Dağıstan, Emine; Özkan, Nezih
Traumatic aneurysms of the superficial temporal artery (STA) are a rare occurrence. Here, we report a very rare case of dissecting aneurysm of superficial temporal artery caused by blunt trauma. 22 year man, admitted with a solitary painless, pulsatile swelling in the right temporal region. 8 mounts ago, he had closed head injury over right temporal region without a skull fracture. A traumatic aneurysm of the STA was diagnosed. Under anesthesia, the aneurysm was completely excised.
Does preoperative conservative management affect the success of arthroscopic repair of partial rotator cuff tear?
(Springer Heidelberg, 2022) Ayanoğlu, Tacettin; Özer, Mustafa; Çetinkaya, Mehmet; Kaptan, Ahmet Yiğit; Ulucaköy, Coşkun; Ataoğlu, Baybars; Kanatlı, Ulunay
Background The aim of this study is to examine the effect of preoperative conservative treatment on the success of high-grade bursal/articular-sided partial rotator cuff repair. Methods Patients who had undergone shoulder arthroscopy in institution for Ellman Stage 3 bursal-side or articular-side partial tears between January 2008 and April 2018 were investigated retrospectively. This study assessed 201 patients diagnosed with isolated partial rotator cuff tears with a history of failed conservative management and persistent shoulder pain who underwent arthroscopic surgery. The demographic data of patients and pre- and postoperative The American Shoulder and Elbow Surgeons Shoulder Scores (ASES) that were recorded in the archive were evaluated. Results While 55 of the patients with Ellman grade 3 bursal-sided partial tears received preoperative conservative management for at least 6 months (Group 1), 62 of them could not tolerate conservative management and early arthroscopic repair was performed (Group 2). On the other hand, 42 of the patients with Ellman grade 3 articular-sided tears received preoperative conservative management (Group 3), 42 of them could not tolerate preoperative conservative management (Group 4). The mean ASES score improvement was 52.33 +/- 8.55 for Group 1, 54.68 +/- 11.29 for Group 2, 48.4 +/- 7.77 for Group 3 and 49.33 +/- 10.05 for Group 4. A statistically significant difference was found between the groups with one-way ANOVA test (p = 0.05). With the Tukey test, this difference was seen to be caused by Group 2. Conclusion Although there are many factors affecting its success, conservative management should be the first option in the treatment of partial rotator cuff tears. However, we think that it should not be insisted especially in patients with bursal-sided tears (> 50% of the tendon thickness) that cannot tolerate conservative management due to severe pain since the results of early arthroscopic repair of bursal-sided tears were found to be better.
The effects of shock waves on lung tissue in acute period: An in vivo study
(Springer, 2007) Eroğlu, Muzaffer; Çimentepe, Ersin; Demirağ, Funda; Ünsal, Ebru; Ünsal, Ali
The acute effects of extracorporeal shock waves on lung morphology were studied by light microscopy in 30 New Zealand rabbits. The left kidneys of the ten animals were exposed to 2,000 shockwaves at 18 kV under anesthesia (ESWL group). Ten rabbits were in the control group; an intramuscular anesthetic agent (ketamine) and intravenous contrast media were administered to ten animals in the sham group. Localization of the left kidneys was achieved following contrast medium injection through an ear vein under fluoroscopic control. The animals were killed after the ESWL procedures and the lungs were removed. Edema, emphysema, hemorrhage, congestion, inflammation, loss of normal structure, and epithelial desquamation were determined and graded between 0 and 3 in all areas of both lungs. In order to determine whether proximity has any effect on the histopathological changes, left and right lungs were evaluated separately as well as upper and lower lobes. We found that ESWL exposed to kidney also affects all areas of the lungs in a rabbit model.
The efficacy of N-2-butyl cyanoacrylate in the fixation of nasal septum to the anterior nasal spine in rabbits
(Springer, 2007) Alkan, Seyhan; Dadaş, Burhan; Çelik, Deniz; Coşkun, Berna Uslu; Yılmaz, Fahrettin; Başak, Tülay
In nasal septal surgery, fixing the caudal portion of the nasal septum to the anterior nasal spine is difficult with the present techniques. N-2-butyl cyanoacrylate is a form of cyanoacrylate which is bioabsorbable and biocompatible. The feasibility and efficacy of the compound, which is easy to apply to the tissues, for the above purpose is investigated in this experimental study. Fourteen New Zealand rabbits were included in the study. The nasal septum was exposed with the open approach (transcolumellar). In the study group (n = 10), the septum was detached from the nasal floor and attached to a point 3 mm lateral to the nasal spine on the right side, using 2-butyl cyanoacrylate. In control group (n = 4) it was deviated 3 mm to the right side and left for spontaneous healing without using any fixation method. Beginning on the third postoperative week, one animal was sacrificed under general anesthesia, every week in the study group and every third week in the control group, and the septum was analysed. Foreign body reaction, histotoxicity, and the structure of the regenerative tissue in the junction of bone and cartilage were analysed with histopathology. The success of stabilization in the study group, where the septum was attached with N-2-butyl cyanoacrylate, was significantly superior to the control group where no fixation method was used (P < 0.05). Histopathologically, there were no differences between the two groups with respect to foreign body reaction, histotoxicity, and the tissue that formed between the bone and cartilage (P > 0.05). This study demonstrated that N-2-Butyl cyanoacrylate was successful in the fixation of the caudal edge of the nasal septum to the anterior nasal spine. No serious infections, foreign body reaction, necrosis or histotoxicity were observed.
Evaluation of eye and serum findings in different waters in rabbits by drowning and submersion modeling
(Tubitak Scientific & Technological Research Council Turkey, 2024) Yılmaz, Aziz; Hösükler, Erdem; Kaymaz, Abdülgani; Üçgül, Ahmet Yücel; Erkol, Zehra Zerrin
Background/aim: This study investigated serum, vitreous, and anterior chamber fluid electrolyte changes, corneal thickness (CT), corneal volume (CV), anterior chamber volume (ACV), and anterior chamber depth (ACD) as an auxiliary diagnostic method in the identification of drowning in fresh or salt water. Materials and methods: The study used 35 healthy, adult, male, white New Zealand rabbits, seperated into five groups (control, saltwater drowning (SWD), saltwater immersion (SWI), freshwater drowning (FWD), freshwater immersion (FWI)). CT, CV, ACV, and ACD measurements were made with Pentacam topography at 0, 2, and 4 h in all groups. Magnesium (mg), sodium (Na), and chlorine (Cl) were measured in the blood at 0 and 2 h, and in blood, vitreous fluid, and humor aqueous at 4 h. Results: It was determined that CT, CV, ACV, and ACD are not of great value in drowning diagnosis and are affected by the fresh or salt water rather than drowning. Vitreous Na, Cl, and Mg levels are ineffective in determining drowning after one h. Anterior chamber fluid may provide valuable information in the differentiation freshwater - saltwater drownings at the 4th h in corpses retrieved from water. Conclusion: Anterior chamber fluid Na and Cl levels, especially in corpses removed from salt water, can be an easily used test that can help diagnose drowning.
Effects of ibuprofen on orthotopic glioma model in rats
(Coll Physicians & Surgeons Pakistan, 2012) Dağıstan, Yaşar; Karaca, İsmail; Bozkurt, Erol Rüştü; Bilir, Ayhan
Objective: To determine the effects of ibuprofen (Ibp) on the vessel proliferation and necrosis in a rat glioma model. Study Design: Experimental, randomized interventional trial. Place and Duration of Study: 1st Neurosurgery Clinic in Bakirkoy Mental Diseases Hospital, Bakirkoy, Istanbul, Turkey, in the year 2010. Methodology: After stereotactic injection of C6/LacZ rat glioma cells into the Wistar rats brain, the rats were randomly assigned to two treatment groups (group 1, control; group 2, Ibp treatment). Rats were sacrificed 18 days after treatment, and number of intra-/peri-tumoural vessels, microendothelial proliferations, immunohistochemistry and necrotic area were evaluated. Results: Ibp treatment significantly decreased tumour tissue, intratumoral vessel number and total tumour area level. The level of Ki67 was significantly decreased in the tumour tissue of group 2. Additionally, the total necrotic area / total tumour volume (%) was significantly less in the tumour tissue of the ibuprofen-treated rats compared to the controls. Conclusion: The data show that the Ibp produced an important reduction in glioma tumour cell proliferation in the rat model.
Obstructive urodynamic findings in idiopathic detrusor overactivity
(Springer, 2007) Kayıgil, Önder; Metin, Ahmet; Atmaca, Ali Fuat
Purpose To investigate the obstructive findings urodynamically in idiopathic detrusor overactivity and compare them (maximum flow rate 'Q max' detrusor pressure at maximum flow 'PQ max') with control group. Materials and Methods Cystometric evaluation and pressure flow studies were performed in 25 women with symptoms of idiopathic detrusor overactivity and control group comprised 40 women with anatomic incontinence without cystocele. Patients with pelvic floor prolapse, motor urgency and poor compliance were excluded from the study. Q max less than 15 ml/s and PQ max more than 40 cm water were accepted as obstruction. Results After cystometric evaluation, obstruction was found in 36% of patients with idiopathic detrusor overactivity and 15% in control group. The range of maximum flow rate and PQ max values were 2-43.7 ml/s (mean 14.47 +/- 10.22) and 10-143 cm water (mean 58.97 +/- 35.13) in idiopathic urge syndrome group. These values were 6.6-51.8 ml/s (mean 23.24 +/- 12.43) and 9.7-61 cm water (mean 25.56 +/- 12.43) respectively in control group. Q max and PQ max parameters were compared statistically between the two groups. Idiopathic detrusor overactivity group had lower mean Q max and higher mean PQ max values than control group (P < 0.001) Table 1. Conclusion Obstruction percentage was found to be more in idiopathic detrusor overactivity group than the control group.
Premenstrual syndrome and premenstrual dysphoric disorder
(Galenos Yayıncılık, 2009) Topçuoğlu, Mehmet Ata; Koç, Önder
Premenstrual syndrome is defined as intense physical , emotional and behavioral changes as well as disturbances in performance, seen in juteal phase of the menstrual period, 7-10 days before menstrual bleeding ; and is most commonly observed between 25-35 ages, This disorder effects the social life of the women. There has been no censenus on the etilology of premenstrual syndrome. in this review , we aimed to emmphasize the importance of this topic while reviewing the avalible literature.
An unusual presentation of peroneal neuropathy secondary to pigmented villonodular synovitis: A case report
(Springer, 2009) Orhan, Zafer; Oktaş, Birhan; Yıldırım, Ümran
Pigmented villonodular synovitis (PVS) is a benign proliferative disorder of unknown origin that affects synovial joints, most commonly the knee. The joint knee can be affected by localized or diffuse form. Diffuse PVS, the aggressive form of the disease is much more problematic, especially when it extends extra-articularly, and is associated with high recurrence rates. Although this disease is categorized as an inflammatory process rather than a neoplasm, it may be locally destructive and involve muscles, tendons, bone and skin. Neural involvement of the disease is rather rare, and only limited knowledge about neuropathy due to PVS we have yet. The presentation of the disease in our patient is a peroneal neuropathy which is the first reported case in English language literature of PVS of the knee seen with extra-articular tissue involvement.
Efficacy of topical levobupivacaine in control of postoperative pain after septoplasty
(Bmc, 2010) Yılmaz, Süleyman; Akbay, Buket Kocaman; Yıldızbaş, Şahnur; Güçlü, Ender; Yaman, Hüseyin; Sezen, Gülbin Yalçın
Objective: To search the efficacy of using Merocele (Medtronic, Minneapolis, MN) soaked with 5 mL of levobupivacaine hydrocloride as a nasal pack in control of postoperative pain after septoplasty. Design: The study was designed as a prospective, double-blind, randomized, controlled study. Forty-one patients who underwent septoplasty operation were included in the analysis. Setting: A tertiary referral hospital in Turkey. Material and Methods: Forty-one patients undergoing septoplasty were divided into two groups. At the end of the operation, Merocele packs were placed inside the nasal cavity. In the levobupivacaine group, each Merocele pack was soaked with 5 mL of levobupivacaine hydrochloride (25 mg/10 mL), and in the control group, Merocele packs were soaked with 5 mL of saline. Main Outcome Measures: Postoperative pain levels were recorded using a visual analogue scale (VAS score, 0-100) at 30 minutes and 1, 2, 8, 12, and 24 hours. Results: We did not find any significant difference between groups regarding age, gender, American Society of Anesthesiologists status, and body mass index. Postoperative VAS values at 30 minutes and 1, 2, 8, and 12 hours were significantly lower in the levobupivacaine group compared with the control group (p < .05). The need for supplemental analgesia was significantly lower in the levobupivacaine group compared with the control group (p < .01) Conclusion: Postoperative pain after septoplasty owing to nasal packing is an important problem, and using levobupivacaine-soaked Merocele as a nasal pack after septoplasty is an effective method for the control of this pain. It is a very easy, effective, and quick method and it improves patient comfort after septoplasty.
Preoperative evaluation of white cataracts with the pentacam
(Elsevier, 2024) Toprak, Güvenç; Alkan, Yunus; Bayrak, Abdullah
Purpose: To evaluate the use of the Pentacam to analyse the presence or absence of fluid pockets under the anterior capsule and their significance in terms of surgical management and prevention of complications. Settings: Abant & Idot;zzet Baysal University Hospital, Bolu, Turkey DESIGN: Randomized, masked, prospective design METHODS: 60 patients with mature cataracts underwent standard phacoemulsification (Phaco) and intraocular lens (IOL) implantation. Patients were divided into 3 groups. Group 1 underwent Phaco+IOL implantation without imaging by Pentacam. Group 2 had fluid detected in Pentacam imaging before the operation and underwent Phaco+IOL implantation with Brazilian method. Group 3 had no fluid detected in Pentacam imaging before the operation and underwent standart Phaco+IOL implantation operation. Results: When the complication rates of 3 different groups were examined separately, they were found to be 15 % in group 1; 5 % in group 2 and 5 % in group 3, respectively. When compared in pairs as Group 1-2, 1-3, and 2-3, respectively (p < 0.01), (p < 0.01), (p > 0.05). The nuclear density of Group 2 and Group 3 was measured, resulting in 30.2 % and 29.6 %, respectively (P = 0.614). Lens thickness, patients with fluid (+) had a thickness of 5.35 mm, while patients with fluid (-) had a thickness of 3.96 mm (p < 0.05). Conclusion: Patients who are not imaged with pentacam before surgery experience more complications than other groups because the presence of fluid is unknown. Central lens thickness was higher in patients with fluid, and there was no significant difference in nuclear density between the groups with and without fluid. Pentacam can show the presence of supcapsular fluid and we recommend that imaging tools be more widely used in cataract surgery. We think that this will enable surgeons to make a more accurate surgical planning and reduce the risk of complications.
Tissue oxygenation
(Galenos Yayıncılık, 2006) Koçoğlu, Hasan
Oxygen that is required for aerobic metabolism is transported to the cell with a series of convective-diffusive processes. 97% of oxygen in arterial blood is carried in combination with hemoglobin, the remaining 3% being dissolved in the plasma. The interaction between hemoglobin and partial oxygen pressure results in oxyhemoglobin dissociation curve which shifts rightward in the presence of acidosis, anemia, hypercapnia, hyperthermia, increased level of 2,3 diphosphoglycerate. The amount of oxygen delivered to the tissue (DO2) is the product of cardiac output and arterial O-2 content, and is about 1020 ml/min when hemoglobin is fully saturated. Oxygen consumption is the rate of 02 uptake from circulation. VO2 is the the product of cardiac output and the chtference between the arterial and venous oxygen content, and is about 251 ml/min. Oxygen consumption depends on the requirement. However, when oxygen. delivery decreases beyond a certain point (critical DO2), VO2 becomes supply dependent. Oxygen extraction(2) (O2ER) is the ratio of oxygen consumption to oxygen supply (O2ER=VO2/DO2=0.25). Mixed venous oxygen saturation (SvO(2)) may represent useful interpretations about DO2 and VO2. Continuous central venous oxygen saturation measurement is suggested to use for early detection of major derangements in oxygen balance. It is aimed in this review to represent the details and clinical interpretations of tissue oxygenation.
Comparison of the short-term effect of coffee, energy drink, and water on the eyes in young healthy subjects
(Springernature, 2023) Toprak, Güvenç; Alkan, Yunus
Purpose: We aim to compare the short-term effects of energy drink (ED), coffee, and water on the eyes of young healthy male subjects.Materials and methods: The right eyes of 30 healthy male subjects were included in this study. We measured the intraocular pressure (IOP), mean arterial pressure (MAP), retinal thickness (RT), choroidal thickness (CT), and retinal nerve fiber layer (RNFL) thickness using spectral domain optical coherence tomography (SD OCT). The measurements for RT and CT were taken at the fovea as well as 1,500 mu m nasal and temporal to the fovea. The measurements of the subjects were performed on the first day before water consumption and at 30 minutes and 60 minutes following intake of 250 mL of water. Measurements were repeated at the same regime on the second day after drinking 250 mL of coffee containing an equal concentration of caffeine in ED (37.5 mg) and on the third day after drinking 250 mL of ED. Repeated measures one-way analysis of variance test was used for statistical analysis.Results: No significant difference was found for ocular perfusion pressure (OPP), MAP, RT, and IOP between the measurements taken on three consecutive days (p>0.05 for all). The CT values for the central, nasal, and temporal segments were significantly reduced in 0-30 and 0-60 minutes following coffee and ED intake (the range of p-value was <0.001-0.027).Conclusions: Both coffee and ED intake caused acute and significant decreases in CT that persisted for one hour in young healthy male subjects. The impact of ED intake on CT was attributed mainly to its caffeine content.
Akut miyokard enfarktüsü sonrası gelişen geniş ventriküler septal rüptürün başarılı tedavisi
(Aves, 2007) Kaya, Ahmet; Kaya, Yasemin; Ordu, Serkan; Özkökeli, Mehmet; Özhan, Hakan; Dağlar, Bahadır; Yazıcı, Mehmet
Postinfarct ventricular septal rupture (VSR) is a rare but mortal complication of acute myocardial infarction (MI). VSR must be diagnosed earlier and the correct treatment must be applied immediately. Abrupt surgical repair is the choice of treatment, which decreases early mortality and improves long term survival. Septal rupture occurs more frequently with anterior than with other types of acute myocardial infarction. VSR occurs usually within 2 weeks after infraction. We describe here a 76-year-old woman with a giant VSR with little hemodynamic disturbance that developed twenty days after anterior myocardial infarction. She was successfully treated with abrupt surgical closure.
Evaluation and comparison of optical coherence tomography angiography (OCTA) parameters in normal and moderate myopic individuals
(Elsevier, 2024) Toprak, Güvenç; Ulaş, Fatih; Kaymaz, Abdulgani; Soydan, Adem; Kaplan, Abdulfatih; Alkan, Yunus; Özdemir, Buse; Bayrak, Abdullah
Objective: The objective of this study was to evaluate and compare Optical Coherence Tomography Angiography (OCTA) parameters in patients with moderate myopia and healthy individuals retrospectively. Methods: A total of 80 male individuals aged 18-20 years were included in the study with 40 moderate myopic and 40 healthy persons. All participants underwent detailed ocular examination including refraction, intraocular pressure (IOP), visual acuity, biomicroscopy, OCTA measurement and optic biometry measurement. Retinal, retinal nerve fiber layer and choroidal layer thicknesses were evaluated in mu m with the help of the software available in the OCTA device. Results: The mean axial length (24.32 +/- 0.53 mm) was statistically significantly higher in the moderate myopic group (24.32 mm) compared to the healthy group (23.33 +/- 0.61 mm) (p < 0.001). Spherical equivalent (SE) was found as -3.79 +/- 0.91 D in the moderate myopic group and -0.22 +/- 0.32 D in the healthy group (p < 0.05). The mean superficial foveal mean density (FovSupMVD) and the mean deep foveal mean density (FovDepMVD) were statistically significantly lower in the moderate myopic group than in the healthy group (both, p < 0.001). The mean retinal temporal thickness (RTt) was statistically significantly lower in the moderate myopic group (p = 0.017). There was a mild negative correlation between axial length and FovSupMVD, FovDepMVD in myopes. In axial length ROC analysis, the cutoff value for moderate myopes was found to be 24.15 mm. Mean superficial foveal mean density (FovSupMVD) and mean deep foveal mean density (FovDepMVD), mean retinal temporal thickness (RTt) were significantly lower in the group above 24.15 mm axial length compared to the group below 24.15 mm axial length (all three, p < 0.001). Foveal avascular zone was significantly higher in the group above 24.15 mm axial length (p = 0.016) Conclusion: The results of our study indicate that the mean axial length and spherical equivalent were significantly higher, while retinal temporal thickness, the mean superficial foveal mean density and the mean deep foveal mean density were significantly lower in patients with myopia up to -6.0 D compared to the healthy individuals.
Effects of modulation of certain TRP channels and voltage-gated potassium channel activities on calcitonin gene- related peptide release in isolated rat hemiskull preparations
(Karger, 2021) Çıtak, Arzu; Kılınç, Erkan; Ankaralı, Seyit; Dağıstan, Yaşar; Yoldaş, Hamit
Doğum sonu kanamayı önlemede rektal misoprostol ve intravenöz oksitosinin etkinliklerinin karşılaştırılması
(Galenos Yayincilik, 2006) Gül, Özlem Kemik; Somunkıran, Aslı; Özdemir, İsmail; Yücel, Oğuz; Demirci, Fuat
Objective: To compare the effectiveness of rectally administered prostaglandine E1 anolog misoprostol and parenterally oxytocin for the prevention of postpartum hemorrhage. Design: Prospective randomized trial Setting: University hospital Patients: 240 full term pregnant women who were in active labor. Interventions: 80 patients in group 1 received 200 mu g misoprostol rectally, 80 patients in Group 2 received 400 mu g rectally misoprostol, and the third group received a solution of 1000 ml 5% DRL + 10 IU oxytocin, immediately after the delivery of the fetus. Main outcome measures: Postpartum blood loss and potential side effects of misoprostol were evaluated. Results: No statistically significant difference was found among the three groups regarding the average blood loss (F=1.50, p=0.22). Average duration of the third stage of labor was similar in all groups (F=1.13, p=0.32). Hematocrit values were similar in the groups both before (F=3.28, p=0.52) and after the delivery and (F=1.84, p=0.16). Conclusions: No differences were found between rectallymisoprostol and oxytocin treatment for the prevention of postpartum hemorrhage. Nevertheless, misoprostol can be preferred in the prevention of postpartum hemorrhage because it does not require special storage conditions, can be used safely in hypertensive patients, can be stored for many years, it is resistant to heat and its side effects such as nausea and vomiting are low when used rectally.
Effect of Urtica Dioica on bacterial translocation in mechanic icter model
(2006) Aydın, Metin; Özaydın, İsmet; İlçe, Zekeriya; Şahin, İdris; Şencan, İrfan; Sılan, Coşkun; Yaşar, Mehmet
Sepsis and renal, hepatic and multi organ failure syndrome, due to bacterial translocation, if the operations were carried out for mechanic icter, still cause high morbidity and mortality.1 It is known that obstructions of the extra hepatic bile ducts increase the translocation of bacteria in the gastrointestinal system. It was reported that bacterial translocation causes sepsis and multiple organ failure syndrome.2 Urtica Dioica (UD) is a perennial plant with stinging hairs belonging to the plant family Urticaceae with a height of 30-100 cm. It is endemic in many parts of Turkey, and seeds have been widely used in folk medicine, particularly in advanced cancer patients, for a long time.3 In some studies, an anti proliferative effect in prostate cancer, an anti inflammatory effect in chronic inflammatory events such as rheumatoid arthritis, a mitogenic effect on the T lymphocytes, and an antidiuretic and hypotensive effect has been reported.4 It was also reported that UD prevents the toxic effect of carbon tetrachloride on the liver.3 The aim of the present study was to investigate the efficiency of UD on bacterial translocation in an experimental model.
Mean platelet volume in nasal polyps.
(2013) Aktaş, Gülali; Şit, Mustafa; Tekçe, Hikmet; Alçelik, Aytekin; Şavlı, Haluk; Şimşek, Tuğçe; Özmen, Evrim
Many studies in literature point out that inflammation related to nasal polyp is mostly dependent on eosinophils and their inflammatory products. Beside eosinophils, platelets may have a role in nasal polyp development. Platelets are involved in haemostasis, tissue repairing and inflammation. However, to our knowledge, there are no reports in the literature that study the association between platelet parameters and nasal polyps. Forty-three patients with nasal polyps and forty-nine healthy controls were enrolled in the study, retrospectively. Laboratory data of patients with nasal polyp were obtained at the time of diagnosis. There were no statistically significant differences between the two groups in terms of white blood count, haemoglobin, haematocrit and platelet count. The mean platelet volume (MPV) value of the nasal polyp group was significantly lower than the control group (p = 0.025). Mean eosinophil count was significantly elevated in the nasal polyp group compared to the control group (p < 0.001). Reduction in MPV may be an indicator for nasal polyp formation. Further studies with a larger study population are needed to detect the possible correlation between eosinophil count and MPV values in patients with nasal polyps.
Efficacy of aprotinin treatment on bilateral blunt chest trauma created in rab
(2013) Kaya, Halil; Kafalı, Mehmet Ertuğrul; Aydın, Kemal; Koçak, Sedat; Şahin, Mustafa; Gül, Mehmet; Cander, Başar
Objectives: To investigate the effects of aprotinin, on blood gasses, oxidant-antioxidant status, and lung histopathology in an experimental bilateral blunt chest trauma model. Methods: Conducted at the Experimental Animal Laboratory of Meram Medical School at Selcuk University, Konya, Turkey, the study comprised 21 New Zealand female albino rabbits who were divided into three groups. Trauma was applied on the sham and aprotinin groups, which was administered intravenous Aprotinin 20.000 U/kg. Arterial blood samples were obtained from all rabbits at hours 0, 3, 24, and 96. At hour 96 after trauma, all rabbits were sacrificed using the decapitation method, and then blood and lung tissue samples were obtained. Blood nitric oxide, malondialdehyde and blood gas measurements were made. Histopathological changes in the lung were examined with a light microscope. Results: While no positive effect of aprotinin was observed on nitric oxide malondialdehyde and partial pressure of carbon dioxide values, it was seen to have an increasing effect on partial oxygen pressure level. Aprotinin had a partial effect on lung histopathology. Conclusion: Aprotinin was determined to have a positive effect on PO2 levels. We could not find any positive effects especially on alveolar haemorrhage.

Güncel Gönderiler