Cerrahi Tıp Bilimleri Bölümü Koleksiyonu
Bu koleksiyon için kalıcı URI
Güncel Gönderiler
Öğe Reply: Comparison of two anticoagulants for pain associated with platelet-rich plasma injections(Springer, 2023) Karanfil, Ertuğrul; Doğan, Ali; Görgü, MetinWe read the letter titled ''Comparison of Two Anticoagulants for Pain Associated with Platelet-Rich Plasma Injections'' authored by Pensato et al. in Aesthetic Plastic Surgery. The authors emphasized an important point. PRP treatments have a lot of variables; preparation method, application, amount of PRP injections, and content (such as number of platelet concentration, presence of leucocytes, and pH). However, in our study, we focused on the pain of injections. We showed that there is a pain difference by using different anticoagulants during PRP preparation, but we did not investigate for possible reason of this pain difference. The use of different anticoagulants may have caused changes in the content, and these alterations could be responsible for the variation in pain. Researches could be done to investigate the reason and the physiology of this effect. Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.Öğe Brucellar prosthetic aortic valve endocarditis(Elsevier Science Inc, 2023) Gözdaş, Hasan Tahsin; Şahin, Sultan Beste; Uçaroğlu, Erhan RenanTo the Editor: A 56-year-old man was admitted to the cardiology outpatient clinic with a chief complaint of progressive dyspnea. His past medical history was remarkable for diabetes mellitus, essential hypertension, coronary artery disease, and left hemiplegia due to a cerebrovascular event. He also underwent prosthetic aortic valve replacement 16 years ago.Öğe A chemically induced experimental colitis model with a simple combination of acetic acid and trinitrobenzene sulphonic acid(Aves, 2023) Cinpolat, Havva Yasemin; Buğdaycı, Güler; Şengül, Neriman; Astarcı, Hesna MüzeyyenBackground: It was aimed to induce a new experimental colitis model by using acetic acid and trinitrobenzene sulphonic acid together and to investigate the severity of inflammation biochemically and histopathologically in comparison with other models. Methods: Fifty-six Wistar albino male rats were randomly divided into 4 groups as control, acetic acid, trinitrobenzene sulphonic acid, and combined groups, and the animals were sacrificed following the induction of colitis on the third day and on the seventh day. The serum amyloid A and myeloperoxidase were tested in plasma samples, and the tumor necrosis factor-alpha, interleukin 33, and ST2 were assayed in colon tissue samples with enzyme-linked immunosorbent assay in addition to histopathological examination. Results: There were statistically significant differences between the combined and the control groups both on the third day and on the seventh day in all parameters. There was no difference between the acetic acid group on the seventh day and the control groups in biochemical parameters. Conclusions: The acetic acid model forms acute colitis. The combined model is found to be more successful in forming inflammation when compared to other models.Öğe Protective and therapeutic effects of okra seed in acute nontraumatic brain injury(Taylor & Francis Ltd, 2023) Yoldaş, Meyri Arzu; Bekdaş, Mervan; Danış, Ayşegül; Çetinkaya, Ayhan; Düzcü, Selma Erdoğan; Alışık, Murat; Kocabey, Hüseyin; Türel, İdrisAimThe purpose of this study was to examine the protective and therapeutic effects of okra (Abelmoschus esculentus [AE]) seed extract, with its known antioxidant, immunomodulatory, and anti-inflammatory properties, in an acetaminophen (paracetamol, N-acetyl- para-aminophenol)-induced model of hepatotoxicity and subsequent acute non-traumatic brain damage.Material and MethodForty male Wistar rats were randomly divided into five equal groups, control, paracetamol (P), okra seed extract (AE), okra seed extract + paracetamol (P + AE), and okra seed extract + paracetamol + N-acetyl cysteine (NAC) (P + AE + N). AE was administered by oral gavage through a gastric tube at 600 mg/kg/day for seven days. On the eighth day of the procedure, a single 1 g/kg dose of paracetamol and 300 mg/kg NAC were injected via the intraperitoneal route 1.5 h after AE administration. Rat tissue specimens were subsequently subjected to biochemical and histopathological analyses. Levels of markers such as S100 calcium-binding protein B (S100B), neuron-specific enolase (NSE), and matrix membrane metalloproteinase-9 (MMP-9) were investigated from rat serum specimens. Malondialdehyde (MDA) and superoxide dismutase (SOD) were also measured to determine oxidant-antioxidant status.ResultsS100B, NSE, MMP-9, MDA levels, and SOD enzyme activities were examined using biochemical methods. MDA levels were significantly lower in the P + AE group and MMP-9 levels in the AE, P + AE, and P + AE + N groups compared to the P group. Histopathological examination results supported the biochemical findingsConclusionOkra seed extract exhibits a protective and therapeutic effect against non-traumatic brain damage resulting from acute paracetamol intoxication. We think that this benefit of AE derives from its antioxidant property.Öğe A cross-cultural adaptation and validation of the Turkish version of American Orthopaedic Foot and Ankle Society Metatarsophalangeal-Interphalangeal Scale (AOFAS-MTP-IP) for the hallux(Turkish Joint Diseases Foundation, 2023) Kalaycıoğlu, Oya; Ayanoğlu, Tacettin; Yılmaz, Ömer Faruk; Turhan, Mahmut TimurObjectives: In this study, we aimed to translate and culturally adapt the American Orthopaedic Foot and Ankle Society (AOFAS) Hallux Metatarsophalangeal (MTP)-Interphalangeal (IP) scale, which is used for the clinical assessment of patients with hallux valgus (HV), into Turkish and to evaluate its validity and reliability. Patients and methods: Between February 2022 and October 2022, a total of 67 patients (18 males, 49 females; mean age: 51.5 & PLUSMN;15.9 years; range, 18 to 68 years) with HV deformity and able to communicate in Turkish were included. Following the translation of the AOFAS hallux MTP-IP scale into Turkish, its cultural appropriateness was confirmed. Intra-rater and inter-rater reliabilities were assessed by intraclass correlation coefficients (ICCs), using data collected by two orthopedists. Agreement among test-retest evaluations was conducted using the Bland-Altman analysis. The construct validity of the scale was determined by the Manchester-Oxford Foot Questionnaire (MOXFQ) and Short Form Health Survey (SF-36). Content validity was confirmed by the floor/ceiling effects. Results: The Turkish AOFAS hallux MTP-IP had an excellent intra-rater reliability of 0.971. The intra-rater reliability of the pain, function, and alignment subscales ranged from 0.904 to 0.978. The inter-rater reliability was 0.913 for the total score, while ranging from 0.838 to 0.918 for the subscales. The total score of the AOFAS hallux MTP-IP had a high correlation with the physical domains of the MOXFQ and SF-36, while weaker correlations with mental domains were observed. No floor/ceiling effect was observed for the overall Turkish AOFAS hallux MTP-IP. Conclusion: The Turkish translated and culturally adapted AOFAS hallux MTP-IP scale is a valid and reliable measure, ensuring its use in assessing the clinical status of Turkish patients with HV deformity.Öğe Abelmoschus esculentus (L.) Moench seed extract alleviates acute acetaminophen induced liver damage in rats(National Institute of Science Communication and Information Resources (NISCAIR), 2023) Kocabey, Hüseyin; Bekdaş, Mervan; Çetinkaya, Ayhan; Düzcü, Selma Erdoğan; Alışık, Murat; Türel, İdrisAcetaminophen (N-acetyl-p-aminophenol, APAP), commonly called the 'paracetamol', is one of the most regularly utilized medicines, particularly in children. When administered at the recommended doses, it is a safe medication. However, oxidative stress and inflammation caused by exposure to toxic doses lead to centrilobular hepatic necrosis. N-acetylcysteine (NAC) is utilized in the therapy, however it has potential adverse effects. On the other hand, it is known that the seeds of the common vegetable Okra, Abelmoschus esculentus (AE), a herbal product, possess antioxidant and anti-inflammatory qualities. In the present study, we explored whether AE can be used as an alternative to standard NAC therapy without any adverse effect in the treatment of acute APAP induced liver injury. Forty male Wistar rats were placed into five groups: Control, AE, APAP, APAP+AE and APAP+AE+NAC groups. Antioxidants such as native thiol and total thiol were found rised in the APAP group by adding AE (p =0.043 and p =0.028, respectively). Anti-inflammatory indicator IL-10 was also found increased, while marker ALT, which is a sign of hepatotoxicity, got decreased (P=0.005 and P <0.001, respectively). Histologically, AE has been shown to improve worsened congestion (P =0.003), cytoplasmic vacuolization (P =0.01), sinusoidal dilatation (P =0.001), Kupffer cell proliferation (P <0.001) and inflammation (P <0.001). These results suggest that the okra seeds may be a potential therapeutic agent for paracetamol induced hepatotoxicity and it can be attributed to the antioxidant and anti-inflammatory properties.Öğe Technical aspects and clinical limitations of sperm DNA fragmentation testing in male infertility a global survey, current guidelines, and expert recommendations(Korean Soc Sexual Medicine & Andrology, 2024) Söğütdelen, Emrullah; Agarwal, Ashok; Farkouh, Ala'a; Saleh, Ramadan; Hamoda, Taha Abo-Almagd Abdel-Meguid; Salvio, GianmariaPurpose: Sperm DNA fragmentation (SDF) is a functional sperm abnormality that can impact reproductive potential, for which four assays have been described in the recently published sixth edition of the WHO laboratory manual for the exami-nation and processing of human semen. The purpose of this study was to examine the global practices related to the use of SDF assays and investigate the barriers and limitations that clinicians face in incorporating these tests into their practice. Materials and Methods: Clinicians managing male infertility were invited to complete an online survey on practices related to SDF diagnostic and treatment approaches. Their responses related to the technical aspects of SDF testing, current profes-sional society guidelines, and the literature were used to generate expert recommendations via the Delphi method. Finally, challenges related to SDF that the clinicians encounter in their daily practice were captured. Results: The survey was completed by 436 reproductive clinicians. Overall, terminal deoxynucleotidyl transferase deoxyuri-dine triphosphate Nick-End Labeling (TUNEL) is the most commonly used assay chosen by 28.6%, followed by the sperm chromatin structure assay (24.1%), and the sperm chromatin dispersion (19.1%). The choice of the assay was largely in-fluenced by availability (70% of respondents). A threshold of 30% was the most selected cut-off value for elevated SDF by 33.7% of clinicians. Of respondents, 53.6% recommend SDF testing after 3 to 5 days of abstinence. Although 75.3% believe SDF testing can provide an explanation for many unknown causes of infertility, the main limiting factors selected by respon-dents are a lack of professional society guideline recommendations (62.7%) and an absence of globally accepted references for SDF interpretation (50.3%). Conclusions: This study represents the largest global survey on the technical aspects of SDF testing as well as the barriers en-countered by clinicians. Unified global recommendations regarding clinician implementation and standard laboratory inter-pretation of SDF testing are crucial.Öğe Assessment of intracranial pressure with ultrasonographic measurement of optic nerve sheath diameter on patients undergoing suspension direct laryngoscopy(Springer, 2023) Karalı, Elif; Demirhan, Abdullah; Güneş, Akif; Yıldız, İsa; Ural, AhmetPurpose The study aims to examine the effect on intracranial pressure by calculating the optic nerve sheath diameter (ONSD) using ultrasound in patients who underwent suspension direct laryngoscopy. Methods Thirty-three patients who underwent suspension direct laryngoscopy were included in this prospective observational study. ONSD measurement was performed using a high-frequency linear probe. The ONSD basal (T0) value was determined using ultrasound in the supine position before the induction. Ultrasonography was used to record ONSD in the Boyce Jackson position (T1) just before inserting the laryngeal blade, in the Boyce Jackson position just before removing the laryngeal blade (T2), and in the supine position (T3) just before extubation. Results A statistically significant rise (p < 0.001) was seen between the patients' baseline ONSD values and the values at T1, T2, and T3. The optic nerve sheat diameter level recorded prior to withdrawing the laryngeal blade (T2) was considerably greater than the ONSD level calculated instantly before insertion of the laryngeal blade (T1) (p < 0.001). The ONSD value prior to extubation (T3) following the removal of the laryngeal blade was considerably smaller than the ONSD value prior removing the laryngeal blade (T2) (p < 0.001). Conclusions This study found that when the laryngeal blade is mounted during the suspension direct laryngoscopy surgery, there is a significant increase in ultrasonographically measured ONSD and increased the ONSD even further during the time the mouth gag was remained in situ. This is the first research to indicate that measuring ONSD with ultrasonography during suspension direct laryngoscopy raises intracranial pressure.Öğe Role of the optic nerve sheath diameter in the assessment of the effectiveness of decompressive surgery after malignant middle cerebral artery infarction(Assoc Arquivos Neuro- Psiquiatria, 2022) Şenol, Özgür; Coşgun, Zeliha; Dağıstan, Emine; Demiryürek, Bekir Enes; Cancan, Seçkin EmreBackground After a case of stroke, intracranial pressure (ICP) must be measured and monitored, and the gold standard method for that is through an invasive technique using an intraventricular or intraparenchymal device. However, The ICP can also be assessed through a non-invasive method, comprised of the measurement of the optic nerve sheath diameter (ONSD) through ultrasound (US). Objective To evaluate the ICP of patients who underwent wide decompressive craniectomy after middle cerebral artery (MCA) infarction via preoperative and postoperative ONSD measurements. Methods A total of 17 patients, aged between 34 and 70 years, diagnosed with malignant MCA infarction with radiological edema and mid-line shift, who underwent decompressive surgery, were eligible. From the records, we collected data on age, sex, preoperative and postoperative Glasgow Coma Scale (GCS) scores, National Institutes of Health Stroke Scale (NIHSS) score, the degree of disability in the preoperative period and three months postoperatively through the scores on the Modified Rankin Scale (MRS), and the preoperative and postoperative midline shift measured by computed tomography (CT) scans of the brain. Results Preoperatively, the mean GCS score was of 8 (range: 7.7-9.2), whereas it was found to be of 12 (range 10-14) on the first postoperative day ( p = 0.001). The mean preoperative NIHSS score was of 21.36 +/- 2.70 and, on the first postoperative day, it was of 5.30 +/- 0.75 ( p < 0.001). As for the midline shift, the mean preoperative value was of 1.33 +/- 0.75 cm, and, on the first postoperative day, 0.36 +/- 0.40 cm ( p < 0.001). And, regarding the ONSD, the mean preoperative measurement was of 5.5 +/- 0.1 mm, and, on the first postoperative day, it was of 5 +/- 0.9 mm ( p < 0.001). Conclusion The ocular US measurement of the ONSD for the preoperative and postoperative monitoring of the ICP seems to be a practical and useful method.Öğe Prognostic factors and their effects on mortality in patients with COVID-19 with pneumothorax(Baycınar Medical Publ-Baycnar Tıbbi Yayıncılık, 2022) Yakşi, Osman; Kılıçgün, AliBackground: The aim of this study was to investigate the factors affecting pneumothorax development, lung expansion difficulty, and the impact on mortality in novel coronavirus 2019 (COVID-19) patients. Methods: Between March 2020 and January 2021, a total of 6,108 COVID-19 patients (3,050 males, 3,058 females; mean age: 49 +/- 17.6 years, range, 12 to 89 years) who presented to our hospital were retrospectively analyzed. The patients were divided into two groups. Group 1 (the COVID-19-pneumothorax group) consisted of patients developing pneumothorax while under treatment for COVID-19. Group 2 (COVID-19-without pneumothorax group) consisted of consecutive patients with pulmonary involvement during the same period, requiring intensive care, but not developing pneumothorax. Biochemical test results were examined for the day of hospitalization, day of transfer to intensive care unit, and Day 5 of intensive care unit stay. Lung parenchyma involvement rates on thoracic computed tomography, duration of drainage, duration of intensive care unit stay, and morbidity/mortality data were investigated. Results: Of all patients with COVID-19, 2,342 were admitted to our clinic and 460 needed intensive care. Pneumothorax developed in 21 patients (0.34% of all patients and 0.9% of hospitalized patients). Significant involvement diffusion on computed tomography, ferritin and D-dimer elevation, and low lymphocyte (%) values were observed in the COVID-19 patients with pneumothorax. Pneumothorax development, and ferritin and D-dimer elevation were most correlated with mortality at regression analysis. There was a significant difference in difficulty in lung expansion between COVID-19 patients who developed pneumothorax and who did not. Conclusion: Pneumothorax may develop in COVID-19 patients whose biochemical parameters worsen, and expansion difficulty may be experienced, which is likely to be associated with mortality.Öğe Rare metastases of clear cell renal cell carcinoma to gastrointestinal tract : Two case reports(Cukurova Univ, Fac Medicine, 2022) Öztürk, Şeyma; Düzcü, Selma Erdoğan; Kayar, Gülşah Ünsal; Boran, ÇetinAdenocarcinomaÖğe Activation of TRESK background potassium channels by cloxyquin exerts protective effects against excitotoxic-induced brain injury and neuroinflammation in neonatal rats(Elseiver, 2022) Dilek, Mustafa; Kılınç, Yasemin Baranoğlu; Kılınç, Erkan; Torun, İbrahim Ethem; Saylan, Aslıhan; Düzcü, Selma ErdoğanWe investigated effects of activation of TRESK channels by selective activator cloxyquin on excitotoxic-induced brain injury and neuroinflammation involving brain mast cells and inflammatory cytokines in neonatal rats. Three different doses of cloxyquin (0.2, 1 and 5 mg/kg) were studied in ibotenate-induced perinatal brain injury (PBI) in P5 rat-pups. Cerebral lesions and mast cells in coronal brain sections were evaluated. Concentrations of activin A, IL-1 beta, IL-6 and IL-10 in brain homogenates were measured using ELISA. Cloxyquin dose-dependently exerted protective effects against excitotoxic-induced neonatal brain injury and neuroinflammation. TRESK channels may be a promising new target for the treatment of PBIs.Öğe Coexistence of COVID-19, Pseudomonas, and thoracic actinomycosis in a cystic bronchiectasis case(BMC, 2023) Afşin, Emine; Küçük, Furkan; Özçelik, Hüsna; Haktanır, Muhammed YavuzActinomycosis often leads to cervicofacial infections, but thoracic involvement may also occur. However, the development of empyema is rare. While being followed up with the diagnosis of asthma and bronchiectasis, our case was hospitalized for infected bronchiectasis. As empyema developed in the follow-up, the pleural effusion was drained by tube thoracostomy. Actinomycosis was diagnosed through pleural effusion cytology. Growth of Pseudomonas aeruginosa was observed in sputum culture, and SARS-CoV2 RT-PCR was also positive in nasopharyngeal sampling. Polymicrobial agents can often be detected in actinomycosis. Actinomycosis cases have also been reported in the post-COVID period. Our case is presented since it would be the first in the literature regarding the coexistence of COVID-19, Pseudomonas, and thoracic Actinomycosis (empyema).Öğe Images in vascular medicine: Sudden mental status change and speech disturbance due to aortic echinococcosis(SAGE Publications Ltd, 2023) Uçaroğlu, Erhan Renan; Gözdaş, Hasan Tahsin; Yılmazsoy, Yunus; Özçelik, Hüsna; Korkmaz, Ufuk Turan Kürşat; Erdem, KemalettinA 52-year-old man presented to our center with speech disorder which occurred after temporary loss of consciousness that lasted nearly 10 seconds and was repeated twice. He had a history of cerebrovascular event nearly 2 months ago. He was conscious and had no acute distress.Öğe An unusual pediatric Monteggia equivalent lesion: A rare case report(Emergency Medicine Physicians Association of Turkey, 2022) Çelik, Metin; Arıkan, Emre; Yılmaz, Ömer FarukMonteggia lesion is a rare fracture in which ulna shaft fracture and radial head dislocation occur together. Monteggia equivalent is the lesion associated with ulna shaft fracture and radius head and/or neck fracture. We offer a case of Monteggia equivalent in a 9-years-old boy. In the surgery of the patient, anatomical plating was performed for ulna shaft fracture and intramedullary nail was applied for radius neck fracture. When we look at the literature, such case reports are very rare. In the 1-year follow-up of the patient, there was no loss in flexion, extension, supination and pronation range of motion.Öğe Effect of quadrant switch on intraocular pressure change in intravitreal aflibercept or ranibizumab injection applications(Springer, 2022) Altıntaş, Melek; Ulaş, Fatih; Çelebi, Serdal; Uyar, EnesObjective To evaluate the effect of injection quadrant switch on the intraocular pressure (IOP) change in intravitreal aflibercept or ranibizumab applications. Methods 123 eyes of 123 patients who received intravitreal injection (IVE) into the superotemporal quadrant at least 10 times for age-related macular degeneration or diabetic macular edema have been recruited. The demographic data, lens status, IOP values (preoperative, postoperative 0th min, and postoperative 30th min), and amount of vitreous reflux (VR) following IVE have been recorded. Next IVE application was performed into the inferotemporal quadrant of the patient, which had never been injected before. Results The mean IOP value at postoperative 0th min was 50.24 +/- 7.66 mmHg after injections into the superotemporal quadrant and was 34.85 +/- 4.96 mmHg after injections into the inferotemporal quadrant. No significant difference was observed between the preoperative and postoperative 30th min-IOP values (p > 0.05), while a significant difference was found between the postoperative 0th min-IOP values among quadrants (p < 0.001). VR was significantly higher in applications into the inferotemporal quadrant than those into the superotemporal quadrant (p < 0.001). Conclusion One of the most principal factors affecting the postoperative short-term IOP increase is the amount of VR, and this amount decreases the IOP following an IVE. The high amount of VR produced in the quadrant where the injection was applied for the first time caused a low-level IOP, while the low amount of VR formed in the quadrant where the repeated injections were applied caused a higher IOP.Öğe Systemic immune-inflammation index for predicting poor outcome after carotid endarterectomy: A novel hematological marker(Sage Publications Ltd, 2022) Yüksel, Ahmet; Velioğlu, Yusuf; Korkmaz, Ufuk Turan Kürşat; Deşer, Serkan Burç; Topal, Dursun; Uçaroğlu, Erhan RenanObjective To investigate the predictive role of systemic immune-inflammation index (SII) on postoperative poor outcome in patients undergoing carotid endarterectomy (CEA). Methods A total of 347 patients undergoing elective isolated CEA between March 2010 and April 2022 were included in this multicenter retrospective observational cohort and risk-prediction study and were divided into two groups as poor outcome group (n = 23) and favorable outcome group (n = 324). Poor outcome was defined as the presence of at least one of the complications within 30 days of surgery including stroke, myocardial infarction, and death. The patients' baseline clinical characteristics, comorbidities, and hematological indices were derived from the complete blood count (CBC) analysis, and perioperative data, outcomes, and complications were screened, recorded, and then compared between the groups. Multivariate logistic regression and receiver-operating characteristic (ROC) curve analyses were conducted following univariate analyses to detect the independent predictors of poor outcome as well as the cutoff values with sensitivity and specificity rates. Results A total of 23 patients out of 347 (6.6%) manifested poor outcome; and stroke, myocardial infarction, and death occurred in 13, 3, and 7 cases, respectively. There were no significant differences between the groups in terms of basic clinical characteristics, comorbidities, and perioperative data, except for lengths of intensive care unit and hospital stays. Although the median values of PLT, PLR, NLR, and SII of the poor outcome group were found to be significantly higher than the favorable outcome group in univariate analysis, only SII was detected to be a significant and independent predictor of poor outcome in multivariate logistic regression analysis (OR = 1.0008; 95% CI: 1.0004-1.0012; p = 0.002). ROC curve analysis revealed that SII of 1356 x 10(3)/mm(3) constituted the cutoff value for predicting poor outcome with 78.3% sensitivity and 64.5% specificity (AUC = 0.746; 95% CI: 0.64-0.851). Conclusions Our study revealed for the first time in the literature that SII significantly predicted poor outcome after CEA. KeywordsÖğe Investigating the magnetic resonance imaging cross-section area that best correlates with intraoperative hamstring autograft size(Turkish Assoc Orthopaedics Traumatology, 2022) Ayanoğlu, Tacettin; Arıkan, Emre; Yılmaz, Onur; Gökkuş, Halil; Kaya, Yasin Emre; Özturan, Kutay EnginObjective: This study aimed to find out the level of the gracilis and semitendinosus tendons that would provide the closest information about the size of the quadruple-stranded hamstring autograft using magnetic resonance images before anterior cruciate ligament reconstruction. Methods: Ninety-six patients (44 males, 52 females) who underwent anterior cruciate ligament reconstruction with quadruple hamstring tendon autografts between January 2015 and March 2020 were retrospectively analyzed. The cross-sectional areas of the gracilis and the semitendinosus tendons at 6 different levels (pes anserinus insertion site, tibial tuberosity, fibular head, tibial plateau, and the proximal insertion sites of the anterior cruciate ligament and the medial collateral ligament were measured on the magnetic resonance images. In addition, the harvested hamstring tendons were measured together (quadrupled) using a standardized graft-sizing block. Results: There was no significant difference between genders in terms of the tendon sizes measured in all levels using magnetic resonance images. There was a strong correlation between the graft size and the measurements made at the tibial plateau level (P <.0001, r = 0.590). Conclusion: Intraoperative quadruple hamstring tendon sizes were most correlated with the magnetic resonance image measurements at the tibial plateau level. To use a hamstring autograft with a diameter of at least 8 mm for anterior cruciate ligament reconstruction, the total area of the 2 tendons should be at least 18.11 mm2 in the magnetic resonance image measurements made at the tibial plateau level.Öğe Protective effects of N-acetyl cysteine on undescended testis after orchiopexy: A rat-model study(Coll Physicians & Surgeons Pakistan, 2023) Kemahlı, Eray; Üyetürk, Uğur; Çetinkaya, Ayhan; Erimşah, Sevilay; Üyetürk, Ümmügül; Gücük, AdnanObjective: To assess the effectiveness of utilising N-acetyl cysteine (NAC) to treat tissue damage brought on by undescended testis (UT) in rats after orchiopexy.Study Design: Experimental study.Place and Duration of the Study: Bolu Abant Izzet Baysal University, Bolu, Turkey, from January 2018 to June 2020.Methodology: The UT model was created by administering flutamide to pregnant rats. Four groups of animals were created as the control group (offsprings of pregnant rats without flutamide), group II (UT), group III (UT + orchiopexy), and group IV (UT + orchiopexy + NAC); each containing eight animals.Results: Group IV had a higher level of glutathione peroxidase than groups III and II (p=0.001 and p=0.002, respectively). Malondialde-hyde was reduced in group IV compared with groups III and II (both p<0.001). There were differences in mean apoptotic cell counts (ACC) among the groups (p<0.001). ACC in group IV was lower than in group III (p<0.001). Sperm counts were higher in group IV than in groups III and II, and in group III they were higher than group II (p<0.001 all) and similar between groups IV and control group (p=0.102).Conclusion: Orchiopexy reduced UT-related testicular damage, additionally using NAC following orchiopexy may further reduce testic-ular damage through its antioxidant effects.Öğe Efficacy of intravesical cocktail therapy with or without dimethyl sulphoxide in interstitial cystitis(Polish Urological Assoc, 2022) Söğütdelen, Emrullah; Çıtamak, BurakIntroduction Interstitial cystitis (IC) is a chronic bladder inflammation with unknown etiologies that impairs the quality of life of patients. We aimed to investigate the efficacy of dimethyl sulphoxide (DMSO) use in the cocktail therapy in IC patients. Material and methods Patients treated with intravesical cocktail therapy which contained a mixture of 10 mL of bupivacaine, 1 mL of heparin, and 9 mL of sodium bicarbonate, was introduced to Group 1, and, 25 mL of DMSO was added to this cocktail and introduced to Group 2. Statistical analyses between groups were assessed by Turkish validated O'Leary Sant score composed of IC Symptom Index (ICSI) and IC Problem Index (ICPI), visual analog scale (VAS) score, and short form-36 (SF-36) questionnaire in the baseline versus post-instillation week 6, month 6, and month 12, comparatively.Results A total of 62 patients (58 women and 4 men) with a median age of 52 (28-76) years were included. Baseline versus post-instillation 6th week of ICSI and ICPI scores were 15 +/- 3.4 vs 7.4 +/- 2.9 and 12.6 +/- 2.8 vs 6.1 +/- 2.7, respectively (p <0.001 and <0.001, respectively). VAS scores of Group 2 were statistically significantly lower than that of Group 1 in the post-instillation month 6 (p = 0.03) whereas, the baseline of VAS scores were similar.Conclusions Intravesical cocktail therapy is an effective and reliable treatment method and can be safely applied with or without DMSO. Adding DMSO to cocktail therapy provides a further decrease in VAS score in the post-instillation month 6.
