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https://hdl.handle.net/20.500.12491/164

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The effect of amyloride and procaine on expression of heat shock protein 70 in rat retina
(Assoc Research Vision Ophthalmology Inc, 2002) Tunç, M.; Güven, A.; Cam, M.; Kaya, M.; Aktan, G.; Ziyal, İ
To identify the effects of amyloride and procaine in retinal expression of heat shock protein 70 (HSP 70) following traumatic injury. Methods: We induced traumatic stress by performing experimental spinal injury in 36 male Wistar-albino rats. We randomised the animals into three groups. Group I received no medications, Group II received intraperitoneal (IP) Procaine 15mg/kg, Group III received Amyloride 30 mg/kg IP. We sacrificed half of the animals in each groups at 12th hour and the remaining half in 24 hours. Following immidiate enucleation we isolated the retinae and detected HSP 70 immunoreactivity in each group. Results: There was moderate expression of HSP 70 in the outer nuclear and inner plexiform layer of the retinae after 12 hours and marked staining with HSP 70 antibodies 24 hours after the injury in all subjects which did not receive any medication. There was little or no immunoreaction to HSP 70 in rat retinae which received procaine or amyloride. Conclusion: Decreased expression of HSP 70 in the retina by procaine and amyloride indicates their neuroprotective role following traumatic stress.
Carcinoma of the gastric stump following billroth ii operation
(Oxford Univ Press, 2011) Çöl, Cavit; Hasdemir, Oğuz; Büyükaşık, Oktay
Impaired subjective sleep quality in irritable bowel syndrome patients with a type D personality
(Cambridge Univ Press, 2013) Yıldırım, Osman; Alçelik, Aytekin; Canan, Fatih; Aktaş, Gülali; Şit, Mustafa; İşçi, Ahsen; Yalçın, Abdullah
The importance of primary surgery in patients with de novo stage IV BC surviving at least 5 years: Protocol MF07-01 randomized clinical trial
(Oxford Univ Press, 2019) Özmen, V.; Özbaş, S.; Karanlık, H.; Müslümanoğlu, M.; Iğcı, A.; Cantürk, Z.; Utkan, Z.
The MF07-01 trial is a multicenter randomized study comparing locoregional treatment (LRT) followed by systemic therapy (ST) with ST alone in de novo stage IV breast cancer (BC) patients. The aim of this study is to evaluate the importance of LRT in patients who lived at least 5 years after the diagnosis of de novo Stage IV BC
Topical vancomycin is more efficient than povidone-ıodine treatment in controlling bacterial growth in methicillin-resistant staphylococcus aureus keratitis model in rabbits
(Taylor & Francis Inc, 2024) Alkan, Yunus; Kaymaz, Abdulgani; Behçet, Mustafa; Bayrak, Abdullah
Purpose: To evaluate the efficacy of topical vancomycin and povidone iodine (PI) application on methicillin-resistant Staphylococcus aureus (MRSA) keratitis model in rabbits. Methods: MRSA keratitis was induced by injecting 0.1 mL MRSA containing 1000 colony-forming units (CFU) into central cornea of right eyes of 24 New Zealand White rabbits. Animals were divided into four groups (n = 6): control (treated with balanced salt solution), 50 mg/mL topical vancomycin, 5% topical PI, and combination; examined before and after treatment, and corneal tissues were harvested for analysis at 9th hour of treatment. Results: Bacterial load was determined as: 7.63 +/- 0.82 log10 CFU/g in control group, 6.95 +/- 1.66 log10 CFU/g in PI group, 4.67 +/- 0.77 log10 CFU/g in combination group, and 4.33 +/- 0.71 log10 CFU/g in vancomycin group (p = 0.001). Median of total clinical score increased significantly from 7 [range: 5-8] to 11.5 [range: 11-15] (p = 0.001) in control group, did not change (6 [range: 5-8] to 7 [range: 5-7]; p = 0.695) in vancomycin group, increased significantly from 7 [range: 5-8] to 12.5 [range: 10-14] (p < 0.001) in PI group, increased significantly from 6.5 [range: 5-7] to 8 [range: 7-9] in combination group (p = 0.002). Post-treatment clinical scores for chemosis, conjunctival injection, iritis, hypopyon, epithelial erosion, and corneal infiltrate were significantly lower in vancomycin-treated groups compared to others (p < 0.05). In PI-treated groups, especially scores for chemosis, conjunctival injection, epithelial erosion and corneal infiltrate were significantly higher than vancomycin (p < 0.05). Conclusion: Topical vancomycin significantly inhibited bacterial growth in MRSA keratitis. However, PI was ineffective in controlling this growth; additionally, exerted toxic effect on ocular surface. When vancomycin was combined with PI, no additional increase in efficacy of treatment was detected compared to only vancomycin.
The combination of furosemide and intravenous hydration does not affect the success of shock wave lithotripsy in renal stone treatment: A prospective randomised single blinded trial
(Bmj Publishing Group, 2015) Kocaaslan, Ramazan; Küçükpolat, Salim; Karadağ, Mert Ali; Erkan, Erkan; Kadihasanoğlu, Mustafa; Özyalvaçlı, Mehmet Emin; Toktaş, Mahmut Gökhan
Objectives To investigate the effect of furosemide given before shock wave lithotripsy (SWL) in patients with renal stones. Methods Two-hundred patients with renal stones measuring 6-20mm in diameter were prospectively included in this study. The treatment group (n=100 patients) received 40mg furosemide 30min before SWL plus 1000mL 0.9% sodium chloride, infused during the procedure. Standard SWL alone was used for the control group (n=100 patients). The effectiveness of SWL was compared between the two groups. Results No statistically significant difference was found between the groups in age, stone size, Hounsfield units, urinary pH, stone density, average number of sessions, average number of pulses or mean energy used. The stone-free rate was 69% in the control group and 71% in the treatment group (p=0.758). Conclusions Although it is an easy and safe application, no positive effects of furosemide and hydration were found.
Peroperatif vazokonstriktör ajan ile infiltrasyon ugyulamasının meme küçültme cerrahisinde kan kaybı üzerine etkisi
(Medknow Publications & Media Pvt Ltd, 2013) Karabekmez, Furkan Erol; Selimoǧlu, Muhammed Nebil; Gökkaya, Ali; Karameşe, Mehtap; Görgü, Metin
Introduction: Breast reduction is a common operation in the field of the Plastic Surgery. Bleeding is one of the most common complications during the surgical procedure and infiltration with diluted epinephrine has been used to decrease blood loss. The aim of this study is evaluating the efficacy of infiltration with diluted epinephrine regarding to the blood hemoglobin level and other clinical parameters in the breast reduction surgery. Material and Methods: The study was planned a retrospective manner and patients' charts are reviewed for cases had breast reduction surgery. 80 patients fit with the criterion were included to the study. 46 patients have not applied infiltration during the surgery named as Group 1, and 34 patients have applied infiltration named as Group 2. Results: Group 1 patients mean hemoglobin levels are 13.5 (+/- 1.2) and 10.4 (+/- 1.3) before and after the surgery respectively, and Group 2 patients mean hemoglobin levels are 13.4 (+/- 1.0) and 11.4 (+/- 1.2) before and after the surgery respectively. Mean decrease on the hemoglobin levels with surgery (postoperative hemoglobin - preoperative hemoglobin) were 3.1 (+/- 1.0) and 2.0 (+/- 1.0) for group 1 and 2 respectively, and the difference between groups were statistically significant (p<0.0001). Conclusions: Infiltration with dilute adrenaline solution before reduction mammoplasty procedure will help surgeon to have confortable and bloodless area during the surgery, and will reduce the decrease in the patient's hemoglobin levels. Infiltration with diluted adrenaline solution should be kept in mind as a routine part of the surgery in the breast reduction procedure.
Doku kaybına neden olan dürtü kontrol bozukluğu
(Medknow Publications & Media Pvt Ltd, 2013) Akdağ, Osman; Sütçü, Mustafa; Karameşe, Mehtap; Karabekmez, Furkan Erol; Tosun, Zekeriya
Many factors experience with tissue defects in plastic surgery, which is an impulse control disorder, trichotillomania and skin picking are rare causes. Trichotillomania is a chronic impulse control disorder characterized by people to pull out the hair from their scalp, eyelashes, eyebrows, or other parts of the body. This conscious or subconscious habit is most commonly performed by young children, adolescents and women. To cause tissue defects is extremely rare. Factors that plastic surgery is a rare skin defects, two cases have been presented in this psychiatric disorder.
Tularemi: Türkiye’de servikal lenfadenopatinin beklenmeyen ancak yaygın bir nedeni. Olgu sunumu ve literatür derlemesi
(Galenos Yayıncılık, 2008) Karabay, Oğuz; Yılmaz, Fahrettin; Gürcan, Şaban
A man who had tonsillopharyngitis and lymphadenomegaly has been admitted to our outpatient clinic. His complaints had been unresponsive to various beta-lactam antibiotics treatments in this period. In this paper, we report a tularemia case and review of the current literature.
Traumatic dissecting aneurysm of superficial temporal artery: A case report
(Derman Medical Publ, 2014) Gezici, Ali Rıza; Dağıstan, Yaşar; Güler, Kamil; Dağıstan, Emine; Özkan, Nezih
Traumatic aneurysms of the superficial temporal artery (STA) are a rare occurrence. Here, we report a very rare case of dissecting aneurysm of superficial temporal artery caused by blunt trauma. 22 year man, admitted with a solitary painless, pulsatile swelling in the right temporal region. 8 mounts ago, he had closed head injury over right temporal region without a skull fracture. A traumatic aneurysm of the STA was diagnosed. Under anesthesia, the aneurysm was completely excised.
The effects of shock waves on lung tissue in acute period: An in vivo study
(Springer, 2007) Eroğlu, Muzaffer; Çimentepe, Ersin; Demirağ, Funda; Ünsal, Ebru; Ünsal, Ali
The acute effects of extracorporeal shock waves on lung morphology were studied by light microscopy in 30 New Zealand rabbits. The left kidneys of the ten animals were exposed to 2,000 shockwaves at 18 kV under anesthesia (ESWL group). Ten rabbits were in the control group; an intramuscular anesthetic agent (ketamine) and intravenous contrast media were administered to ten animals in the sham group. Localization of the left kidneys was achieved following contrast medium injection through an ear vein under fluoroscopic control. The animals were killed after the ESWL procedures and the lungs were removed. Edema, emphysema, hemorrhage, congestion, inflammation, loss of normal structure, and epithelial desquamation were determined and graded between 0 and 3 in all areas of both lungs. In order to determine whether proximity has any effect on the histopathological changes, left and right lungs were evaluated separately as well as upper and lower lobes. We found that ESWL exposed to kidney also affects all areas of the lungs in a rabbit model.
Does preoperative conservative management affect the success of arthroscopic repair of partial rotator cuff tear?
(Springer Heidelberg, 2022) Ayanoğlu, Tacettin; Özer, Mustafa; Çetinkaya, Mehmet; Kaptan, Ahmet Yiğit; Ulucaköy, Coşkun; Ataoğlu, Baybars; Kanatlı, Ulunay
Background The aim of this study is to examine the effect of preoperative conservative treatment on the success of high-grade bursal/articular-sided partial rotator cuff repair. Methods Patients who had undergone shoulder arthroscopy in institution for Ellman Stage 3 bursal-side or articular-side partial tears between January 2008 and April 2018 were investigated retrospectively. This study assessed 201 patients diagnosed with isolated partial rotator cuff tears with a history of failed conservative management and persistent shoulder pain who underwent arthroscopic surgery. The demographic data of patients and pre- and postoperative The American Shoulder and Elbow Surgeons Shoulder Scores (ASES) that were recorded in the archive were evaluated. Results While 55 of the patients with Ellman grade 3 bursal-sided partial tears received preoperative conservative management for at least 6 months (Group 1), 62 of them could not tolerate conservative management and early arthroscopic repair was performed (Group 2). On the other hand, 42 of the patients with Ellman grade 3 articular-sided tears received preoperative conservative management (Group 3), 42 of them could not tolerate preoperative conservative management (Group 4). The mean ASES score improvement was 52.33 +/- 8.55 for Group 1, 54.68 +/- 11.29 for Group 2, 48.4 +/- 7.77 for Group 3 and 49.33 +/- 10.05 for Group 4. A statistically significant difference was found between the groups with one-way ANOVA test (p = 0.05). With the Tukey test, this difference was seen to be caused by Group 2. Conclusion Although there are many factors affecting its success, conservative management should be the first option in the treatment of partial rotator cuff tears. However, we think that it should not be insisted especially in patients with bursal-sided tears (> 50% of the tendon thickness) that cannot tolerate conservative management due to severe pain since the results of early arthroscopic repair of bursal-sided tears were found to be better.
The efficacy of N-2-butyl cyanoacrylate in the fixation of nasal septum to the anterior nasal spine in rabbits
(Springer, 2007) Alkan, Seyhan; Dadaş, Burhan; Çelik, Deniz; Coşkun, Berna Uslu; Yılmaz, Fahrettin; Başak, Tülay
In nasal septal surgery, fixing the caudal portion of the nasal septum to the anterior nasal spine is difficult with the present techniques. N-2-butyl cyanoacrylate is a form of cyanoacrylate which is bioabsorbable and biocompatible. The feasibility and efficacy of the compound, which is easy to apply to the tissues, for the above purpose is investigated in this experimental study. Fourteen New Zealand rabbits were included in the study. The nasal septum was exposed with the open approach (transcolumellar). In the study group (n = 10), the septum was detached from the nasal floor and attached to a point 3 mm lateral to the nasal spine on the right side, using 2-butyl cyanoacrylate. In control group (n = 4) it was deviated 3 mm to the right side and left for spontaneous healing without using any fixation method. Beginning on the third postoperative week, one animal was sacrificed under general anesthesia, every week in the study group and every third week in the control group, and the septum was analysed. Foreign body reaction, histotoxicity, and the structure of the regenerative tissue in the junction of bone and cartilage were analysed with histopathology. The success of stabilization in the study group, where the septum was attached with N-2-butyl cyanoacrylate, was significantly superior to the control group where no fixation method was used (P < 0.05). Histopathologically, there were no differences between the two groups with respect to foreign body reaction, histotoxicity, and the tissue that formed between the bone and cartilage (P > 0.05). This study demonstrated that N-2-Butyl cyanoacrylate was successful in the fixation of the caudal edge of the nasal septum to the anterior nasal spine. No serious infections, foreign body reaction, necrosis or histotoxicity were observed.
Evaluation of eye and serum findings in different waters in rabbits by drowning and submersion modeling
(Tubitak Scientific & Technological Research Council Turkey, 2024) Yılmaz, Aziz; Hösükler, Erdem; Kaymaz, Abdülgani; Üçgül, Ahmet Yücel; Erkol, Zehra Zerrin
Background/aim: This study investigated serum, vitreous, and anterior chamber fluid electrolyte changes, corneal thickness (CT), corneal volume (CV), anterior chamber volume (ACV), and anterior chamber depth (ACD) as an auxiliary diagnostic method in the identification of drowning in fresh or salt water. Materials and methods: The study used 35 healthy, adult, male, white New Zealand rabbits, seperated into five groups (control, saltwater drowning (SWD), saltwater immersion (SWI), freshwater drowning (FWD), freshwater immersion (FWI)). CT, CV, ACV, and ACD measurements were made with Pentacam topography at 0, 2, and 4 h in all groups. Magnesium (mg), sodium (Na), and chlorine (Cl) were measured in the blood at 0 and 2 h, and in blood, vitreous fluid, and humor aqueous at 4 h. Results: It was determined that CT, CV, ACV, and ACD are not of great value in drowning diagnosis and are affected by the fresh or salt water rather than drowning. Vitreous Na, Cl, and Mg levels are ineffective in determining drowning after one h. Anterior chamber fluid may provide valuable information in the differentiation freshwater - saltwater drownings at the 4th h in corpses retrieved from water. Conclusion: Anterior chamber fluid Na and Cl levels, especially in corpses removed from salt water, can be an easily used test that can help diagnose drowning.
Effects of ibuprofen on orthotopic glioma model in rats
(Coll Physicians & Surgeons Pakistan, 2012) Dağıstan, Yaşar; Karaca, İsmail; Bozkurt, Erol Rüştü; Bilir, Ayhan
Objective: To determine the effects of ibuprofen (Ibp) on the vessel proliferation and necrosis in a rat glioma model. Study Design: Experimental, randomized interventional trial. Place and Duration of Study: 1st Neurosurgery Clinic in Bakirkoy Mental Diseases Hospital, Bakirkoy, Istanbul, Turkey, in the year 2010. Methodology: After stereotactic injection of C6/LacZ rat glioma cells into the Wistar rats brain, the rats were randomly assigned to two treatment groups (group 1, control; group 2, Ibp treatment). Rats were sacrificed 18 days after treatment, and number of intra-/peri-tumoural vessels, microendothelial proliferations, immunohistochemistry and necrotic area were evaluated. Results: Ibp treatment significantly decreased tumour tissue, intratumoral vessel number and total tumour area level. The level of Ki67 was significantly decreased in the tumour tissue of group 2. Additionally, the total necrotic area / total tumour volume (%) was significantly less in the tumour tissue of the ibuprofen-treated rats compared to the controls. Conclusion: The data show that the Ibp produced an important reduction in glioma tumour cell proliferation in the rat model.
Premenstrual syndrome and premenstrual dysphoric disorder
(Galenos Yayıncılık, 2009) Topçuoğlu, Mehmet Ata; Koç, Önder
Premenstrual syndrome is defined as intense physical , emotional and behavioral changes as well as disturbances in performance, seen in juteal phase of the menstrual period, 7-10 days before menstrual bleeding ; and is most commonly observed between 25-35 ages, This disorder effects the social life of the women. There has been no censenus on the etilology of premenstrual syndrome. in this review , we aimed to emmphasize the importance of this topic while reviewing the avalible literature.
Obstructive urodynamic findings in idiopathic detrusor overactivity
(Springer, 2007) Kayıgil, Önder; Metin, Ahmet; Atmaca, Ali Fuat
Purpose To investigate the obstructive findings urodynamically in idiopathic detrusor overactivity and compare them (maximum flow rate 'Q max' detrusor pressure at maximum flow 'PQ max') with control group. Materials and Methods Cystometric evaluation and pressure flow studies were performed in 25 women with symptoms of idiopathic detrusor overactivity and control group comprised 40 women with anatomic incontinence without cystocele. Patients with pelvic floor prolapse, motor urgency and poor compliance were excluded from the study. Q max less than 15 ml/s and PQ max more than 40 cm water were accepted as obstruction. Results After cystometric evaluation, obstruction was found in 36% of patients with idiopathic detrusor overactivity and 15% in control group. The range of maximum flow rate and PQ max values were 2-43.7 ml/s (mean 14.47 +/- 10.22) and 10-143 cm water (mean 58.97 +/- 35.13) in idiopathic urge syndrome group. These values were 6.6-51.8 ml/s (mean 23.24 +/- 12.43) and 9.7-61 cm water (mean 25.56 +/- 12.43) respectively in control group. Q max and PQ max parameters were compared statistically between the two groups. Idiopathic detrusor overactivity group had lower mean Q max and higher mean PQ max values than control group (P < 0.001) Table 1. Conclusion Obstruction percentage was found to be more in idiopathic detrusor overactivity group than the control group.
Efficacy of topical levobupivacaine in control of postoperative pain after septoplasty
(Bmc, 2010) Yılmaz, Süleyman; Akbay, Buket Kocaman; Yıldızbaş, Şahnur; Güçlü, Ender; Yaman, Hüseyin; Sezen, Gülbin Yalçın
Objective: To search the efficacy of using Merocele (Medtronic, Minneapolis, MN) soaked with 5 mL of levobupivacaine hydrocloride as a nasal pack in control of postoperative pain after septoplasty. Design: The study was designed as a prospective, double-blind, randomized, controlled study. Forty-one patients who underwent septoplasty operation were included in the analysis. Setting: A tertiary referral hospital in Turkey. Material and Methods: Forty-one patients undergoing septoplasty were divided into two groups. At the end of the operation, Merocele packs were placed inside the nasal cavity. In the levobupivacaine group, each Merocele pack was soaked with 5 mL of levobupivacaine hydrochloride (25 mg/10 mL), and in the control group, Merocele packs were soaked with 5 mL of saline. Main Outcome Measures: Postoperative pain levels were recorded using a visual analogue scale (VAS score, 0-100) at 30 minutes and 1, 2, 8, 12, and 24 hours. Results: We did not find any significant difference between groups regarding age, gender, American Society of Anesthesiologists status, and body mass index. Postoperative VAS values at 30 minutes and 1, 2, 8, and 12 hours were significantly lower in the levobupivacaine group compared with the control group (p < .05). The need for supplemental analgesia was significantly lower in the levobupivacaine group compared with the control group (p < .01) Conclusion: Postoperative pain after septoplasty owing to nasal packing is an important problem, and using levobupivacaine-soaked Merocele as a nasal pack after septoplasty is an effective method for the control of this pain. It is a very easy, effective, and quick method and it improves patient comfort after septoplasty.
An unusual presentation of peroneal neuropathy secondary to pigmented villonodular synovitis: A case report
(Springer, 2009) Orhan, Zafer; Oktaş, Birhan; Yıldırım, Ümran
Pigmented villonodular synovitis (PVS) is a benign proliferative disorder of unknown origin that affects synovial joints, most commonly the knee. The joint knee can be affected by localized or diffuse form. Diffuse PVS, the aggressive form of the disease is much more problematic, especially when it extends extra-articularly, and is associated with high recurrence rates. Although this disease is categorized as an inflammatory process rather than a neoplasm, it may be locally destructive and involve muscles, tendons, bone and skin. Neural involvement of the disease is rather rare, and only limited knowledge about neuropathy due to PVS we have yet. The presentation of the disease in our patient is a peroneal neuropathy which is the first reported case in English language literature of PVS of the knee seen with extra-articular tissue involvement.
Preoperative evaluation of white cataracts with the pentacam
(Elsevier, 2024) Toprak, Güvenç; Alkan, Yunus; Bayrak, Abdullah
Purpose: To evaluate the use of the Pentacam to analyse the presence or absence of fluid pockets under the anterior capsule and their significance in terms of surgical management and prevention of complications. Settings: Abant & Idot;zzet Baysal University Hospital, Bolu, Turkey DESIGN: Randomized, masked, prospective design METHODS: 60 patients with mature cataracts underwent standard phacoemulsification (Phaco) and intraocular lens (IOL) implantation. Patients were divided into 3 groups. Group 1 underwent Phaco+IOL implantation without imaging by Pentacam. Group 2 had fluid detected in Pentacam imaging before the operation and underwent Phaco+IOL implantation with Brazilian method. Group 3 had no fluid detected in Pentacam imaging before the operation and underwent standart Phaco+IOL implantation operation. Results: When the complication rates of 3 different groups were examined separately, they were found to be 15 % in group 1; 5 % in group 2 and 5 % in group 3, respectively. When compared in pairs as Group 1-2, 1-3, and 2-3, respectively (p < 0.01), (p < 0.01), (p > 0.05). The nuclear density of Group 2 and Group 3 was measured, resulting in 30.2 % and 29.6 %, respectively (P = 0.614). Lens thickness, patients with fluid (+) had a thickness of 5.35 mm, while patients with fluid (-) had a thickness of 3.96 mm (p < 0.05). Conclusion: Patients who are not imaged with pentacam before surgery experience more complications than other groups because the presence of fluid is unknown. Central lens thickness was higher in patients with fluid, and there was no significant difference in nuclear density between the groups with and without fluid. Pentacam can show the presence of supcapsular fluid and we recommend that imaging tools be more widely used in cataract surgery. We think that this will enable surgeons to make a more accurate surgical planning and reduce the risk of complications.

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