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Öğe Obstructive urodynamic findings in idiopathic detrusor overactivity(Springer, 2007) Kayıgil, Önder; Metin, Ahmet; Atmaca, Ali FuatPurpose To investigate the obstructive findings urodynamically in idiopathic detrusor overactivity and compare them (maximum flow rate 'Q max' detrusor pressure at maximum flow 'PQ max') with control group. Materials and Methods Cystometric evaluation and pressure flow studies were performed in 25 women with symptoms of idiopathic detrusor overactivity and control group comprised 40 women with anatomic incontinence without cystocele. Patients with pelvic floor prolapse, motor urgency and poor compliance were excluded from the study. Q max less than 15 ml/s and PQ max more than 40 cm water were accepted as obstruction. Results After cystometric evaluation, obstruction was found in 36% of patients with idiopathic detrusor overactivity and 15% in control group. The range of maximum flow rate and PQ max values were 2-43.7 ml/s (mean 14.47 +/- 10.22) and 10-143 cm water (mean 58.97 +/- 35.13) in idiopathic urge syndrome group. These values were 6.6-51.8 ml/s (mean 23.24 +/- 12.43) and 9.7-61 cm water (mean 25.56 +/- 12.43) respectively in control group. Q max and PQ max parameters were compared statistically between the two groups. Idiopathic detrusor overactivity group had lower mean Q max and higher mean PQ max values than control group (P < 0.001) Table 1. Conclusion Obstruction percentage was found to be more in idiopathic detrusor overactivity group than the control group.Öğe Premenstrual syndrome and premenstrual dysphoric disorder(Galenos Yayıncılık, 2009) Topçuoğlu, Mehmet Ata; Koç, ÖnderPremenstrual syndrome is defined as intense physical , emotional and behavioral changes as well as disturbances in performance, seen in juteal phase of the menstrual period, 7-10 days before menstrual bleeding ; and is most commonly observed between 25-35 ages, This disorder effects the social life of the women. There has been no censenus on the etilology of premenstrual syndrome. in this review , we aimed to emmphasize the importance of this topic while reviewing the avalible literature.Öğe An unusual presentation of peroneal neuropathy secondary to pigmented villonodular synovitis: A case report(Springer, 2009) Orhan, Zafer; Oktaş, Birhan; Yıldırım, ÜmranPigmented villonodular synovitis (PVS) is a benign proliferative disorder of unknown origin that affects synovial joints, most commonly the knee. The joint knee can be affected by localized or diffuse form. Diffuse PVS, the aggressive form of the disease is much more problematic, especially when it extends extra-articularly, and is associated with high recurrence rates. Although this disease is categorized as an inflammatory process rather than a neoplasm, it may be locally destructive and involve muscles, tendons, bone and skin. Neural involvement of the disease is rather rare, and only limited knowledge about neuropathy due to PVS we have yet. The presentation of the disease in our patient is a peroneal neuropathy which is the first reported case in English language literature of PVS of the knee seen with extra-articular tissue involvement.Öğe Efficacy of topical levobupivacaine in control of postoperative pain after septoplasty(Bmc, 2010) Yılmaz, Süleyman; Akbay, Buket Kocaman; Yıldızbaş, Şahnur; Güçlü, Ender; Yaman, Hüseyin; Sezen, Gülbin YalçınObjective: To search the efficacy of using Merocele (Medtronic, Minneapolis, MN) soaked with 5 mL of levobupivacaine hydrocloride as a nasal pack in control of postoperative pain after septoplasty. Design: The study was designed as a prospective, double-blind, randomized, controlled study. Forty-one patients who underwent septoplasty operation were included in the analysis. Setting: A tertiary referral hospital in Turkey. Material and Methods: Forty-one patients undergoing septoplasty were divided into two groups. At the end of the operation, Merocele packs were placed inside the nasal cavity. In the levobupivacaine group, each Merocele pack was soaked with 5 mL of levobupivacaine hydrochloride (25 mg/10 mL), and in the control group, Merocele packs were soaked with 5 mL of saline. Main Outcome Measures: Postoperative pain levels were recorded using a visual analogue scale (VAS score, 0-100) at 30 minutes and 1, 2, 8, 12, and 24 hours. Results: We did not find any significant difference between groups regarding age, gender, American Society of Anesthesiologists status, and body mass index. Postoperative VAS values at 30 minutes and 1, 2, 8, and 12 hours were significantly lower in the levobupivacaine group compared with the control group (p < .05). The need for supplemental analgesia was significantly lower in the levobupivacaine group compared with the control group (p < .01) Conclusion: Postoperative pain after septoplasty owing to nasal packing is an important problem, and using levobupivacaine-soaked Merocele as a nasal pack after septoplasty is an effective method for the control of this pain. It is a very easy, effective, and quick method and it improves patient comfort after septoplasty.Öğe Preoperative evaluation of white cataracts with the pentacam(Elsevier, 2024) Toprak, Güvenç; Alkan, Yunus; Bayrak, AbdullahPurpose: To evaluate the use of the Pentacam to analyse the presence or absence of fluid pockets under the anterior capsule and their significance in terms of surgical management and prevention of complications. Settings: Abant & Idot;zzet Baysal University Hospital, Bolu, Turkey DESIGN: Randomized, masked, prospective design METHODS: 60 patients with mature cataracts underwent standard phacoemulsification (Phaco) and intraocular lens (IOL) implantation. Patients were divided into 3 groups. Group 1 underwent Phaco+IOL implantation without imaging by Pentacam. Group 2 had fluid detected in Pentacam imaging before the operation and underwent Phaco+IOL implantation with Brazilian method. Group 3 had no fluid detected in Pentacam imaging before the operation and underwent standart Phaco+IOL implantation operation. Results: When the complication rates of 3 different groups were examined separately, they were found to be 15 % in group 1; 5 % in group 2 and 5 % in group 3, respectively. When compared in pairs as Group 1-2, 1-3, and 2-3, respectively (p < 0.01), (p < 0.01), (p > 0.05). The nuclear density of Group 2 and Group 3 was measured, resulting in 30.2 % and 29.6 %, respectively (P = 0.614). Lens thickness, patients with fluid (+) had a thickness of 5.35 mm, while patients with fluid (-) had a thickness of 3.96 mm (p < 0.05). Conclusion: Patients who are not imaged with pentacam before surgery experience more complications than other groups because the presence of fluid is unknown. Central lens thickness was higher in patients with fluid, and there was no significant difference in nuclear density between the groups with and without fluid. Pentacam can show the presence of supcapsular fluid and we recommend that imaging tools be more widely used in cataract surgery. We think that this will enable surgeons to make a more accurate surgical planning and reduce the risk of complications.Öğe Tissue oxygenation(Galenos Yayıncılık, 2006) Koçoğlu, HasanOxygen that is required for aerobic metabolism is transported to the cell with a series of convective-diffusive processes. 97% of oxygen in arterial blood is carried in combination with hemoglobin, the remaining 3% being dissolved in the plasma. The interaction between hemoglobin and partial oxygen pressure results in oxyhemoglobin dissociation curve which shifts rightward in the presence of acidosis, anemia, hypercapnia, hyperthermia, increased level of 2,3 diphosphoglycerate. The amount of oxygen delivered to the tissue (DO2) is the product of cardiac output and arterial O-2 content, and is about 1020 ml/min when hemoglobin is fully saturated. Oxygen consumption is the rate of 02 uptake from circulation. VO2 is the the product of cardiac output and the chtference between the arterial and venous oxygen content, and is about 251 ml/min. Oxygen consumption depends on the requirement. However, when oxygen. delivery decreases beyond a certain point (critical DO2), VO2 becomes supply dependent. Oxygen extraction(2) (O2ER) is the ratio of oxygen consumption to oxygen supply (O2ER=VO2/DO2=0.25). Mixed venous oxygen saturation (SvO(2)) may represent useful interpretations about DO2 and VO2. Continuous central venous oxygen saturation measurement is suggested to use for early detection of major derangements in oxygen balance. It is aimed in this review to represent the details and clinical interpretations of tissue oxygenation.Öğe Comparison of the short-term effect of coffee, energy drink, and water on the eyes in young healthy subjects(Springernature, 2023) Toprak, Güvenç; Alkan, YunusPurpose: We aim to compare the short-term effects of energy drink (ED), coffee, and water on the eyes of young healthy male subjects.Materials and methods: The right eyes of 30 healthy male subjects were included in this study. We measured the intraocular pressure (IOP), mean arterial pressure (MAP), retinal thickness (RT), choroidal thickness (CT), and retinal nerve fiber layer (RNFL) thickness using spectral domain optical coherence tomography (SD OCT). The measurements for RT and CT were taken at the fovea as well as 1,500 mu m nasal and temporal to the fovea. The measurements of the subjects were performed on the first day before water consumption and at 30 minutes and 60 minutes following intake of 250 mL of water. Measurements were repeated at the same regime on the second day after drinking 250 mL of coffee containing an equal concentration of caffeine in ED (37.5 mg) and on the third day after drinking 250 mL of ED. Repeated measures one-way analysis of variance test was used for statistical analysis.Results: No significant difference was found for ocular perfusion pressure (OPP), MAP, RT, and IOP between the measurements taken on three consecutive days (p>0.05 for all). The CT values for the central, nasal, and temporal segments were significantly reduced in 0-30 and 0-60 minutes following coffee and ED intake (the range of p-value was <0.001-0.027).Conclusions: Both coffee and ED intake caused acute and significant decreases in CT that persisted for one hour in young healthy male subjects. The impact of ED intake on CT was attributed mainly to its caffeine content.Öğe Akut miyokard enfarktüsü sonrası gelişen geniş ventriküler septal rüptürün başarılı tedavisi(Aves, 2007) Kaya, Ahmet; Kaya, Yasemin; Ordu, Serkan; Özkökeli, Mehmet; Özhan, Hakan; Dağlar, Bahadır; Yazıcı, MehmetPostinfarct ventricular septal rupture (VSR) is a rare but mortal complication of acute myocardial infarction (MI). VSR must be diagnosed earlier and the correct treatment must be applied immediately. Abrupt surgical repair is the choice of treatment, which decreases early mortality and improves long term survival. Septal rupture occurs more frequently with anterior than with other types of acute myocardial infarction. VSR occurs usually within 2 weeks after infraction. We describe here a 76-year-old woman with a giant VSR with little hemodynamic disturbance that developed twenty days after anterior myocardial infarction. She was successfully treated with abrupt surgical closure.Öğe Evaluation and comparison of optical coherence tomography angiography (OCTA) parameters in normal and moderate myopic individuals(Elsevier, 2024) Toprak, Güvenç; Ulaş, Fatih; Kaymaz, Abdulgani; Soydan, Adem; Kaplan, Abdulfatih; Alkan, Yunus; Özdemir, Buse; Bayrak, AbdullahObjective: The objective of this study was to evaluate and compare Optical Coherence Tomography Angiography (OCTA) parameters in patients with moderate myopia and healthy individuals retrospectively. Methods: A total of 80 male individuals aged 18-20 years were included in the study with 40 moderate myopic and 40 healthy persons. All participants underwent detailed ocular examination including refraction, intraocular pressure (IOP), visual acuity, biomicroscopy, OCTA measurement and optic biometry measurement. Retinal, retinal nerve fiber layer and choroidal layer thicknesses were evaluated in mu m with the help of the software available in the OCTA device. Results: The mean axial length (24.32 +/- 0.53 mm) was statistically significantly higher in the moderate myopic group (24.32 mm) compared to the healthy group (23.33 +/- 0.61 mm) (p < 0.001). Spherical equivalent (SE) was found as -3.79 +/- 0.91 D in the moderate myopic group and -0.22 +/- 0.32 D in the healthy group (p < 0.05). The mean superficial foveal mean density (FovSupMVD) and the mean deep foveal mean density (FovDepMVD) were statistically significantly lower in the moderate myopic group than in the healthy group (both, p < 0.001). The mean retinal temporal thickness (RTt) was statistically significantly lower in the moderate myopic group (p = 0.017). There was a mild negative correlation between axial length and FovSupMVD, FovDepMVD in myopes. In axial length ROC analysis, the cutoff value for moderate myopes was found to be 24.15 mm. Mean superficial foveal mean density (FovSupMVD) and mean deep foveal mean density (FovDepMVD), mean retinal temporal thickness (RTt) were significantly lower in the group above 24.15 mm axial length compared to the group below 24.15 mm axial length (all three, p < 0.001). Foveal avascular zone was significantly higher in the group above 24.15 mm axial length (p = 0.016) Conclusion: The results of our study indicate that the mean axial length and spherical equivalent were significantly higher, while retinal temporal thickness, the mean superficial foveal mean density and the mean deep foveal mean density were significantly lower in patients with myopia up to -6.0 D compared to the healthy individuals.Öğe Effects of modulation of certain TRP channels and voltage-gated potassium channel activities on calcitonin gene- related peptide release in isolated rat hemiskull preparations(Karger, 2021) Çıtak, Arzu; Kılınç, Erkan; Ankaralı, Seyit; Dağıstan, Yaşar; Yoldaş, HamitÖğe Doğum sonu kanamayı önlemede rektal misoprostol ve intravenöz oksitosinin etkinliklerinin karşılaştırılması(Galenos Yayincilik, 2006) Gül, Özlem Kemik; Somunkıran, Aslı; Özdemir, İsmail; Yücel, Oğuz; Demirci, FuatObjective: To compare the effectiveness of rectally administered prostaglandine E1 anolog misoprostol and parenterally oxytocin for the prevention of postpartum hemorrhage. Design: Prospective randomized trial Setting: University hospital Patients: 240 full term pregnant women who were in active labor. Interventions: 80 patients in group 1 received 200 mu g misoprostol rectally, 80 patients in Group 2 received 400 mu g rectally misoprostol, and the third group received a solution of 1000 ml 5% DRL + 10 IU oxytocin, immediately after the delivery of the fetus. Main outcome measures: Postpartum blood loss and potential side effects of misoprostol were evaluated. Results: No statistically significant difference was found among the three groups regarding the average blood loss (F=1.50, p=0.22). Average duration of the third stage of labor was similar in all groups (F=1.13, p=0.32). Hematocrit values were similar in the groups both before (F=3.28, p=0.52) and after the delivery and (F=1.84, p=0.16). Conclusions: No differences were found between rectallymisoprostol and oxytocin treatment for the prevention of postpartum hemorrhage. Nevertheless, misoprostol can be preferred in the prevention of postpartum hemorrhage because it does not require special storage conditions, can be used safely in hypertensive patients, can be stored for many years, it is resistant to heat and its side effects such as nausea and vomiting are low when used rectally.Öğe Effect of Urtica Dioica on bacterial translocation in mechanic icter model(2006) Aydın, Metin; Özaydın, İsmet; İlçe, Zekeriya; Şahin, İdris; Şencan, İrfan; Sılan, Coşkun; Yaşar, MehmetSepsis and renal, hepatic and multi organ failure syndrome, due to bacterial translocation, if the operations were carried out for mechanic icter, still cause high morbidity and mortality.1 It is known that obstructions of the extra hepatic bile ducts increase the translocation of bacteria in the gastrointestinal system. It was reported that bacterial translocation causes sepsis and multiple organ failure syndrome.2 Urtica Dioica (UD) is a perennial plant with stinging hairs belonging to the plant family Urticaceae with a height of 30-100 cm. It is endemic in many parts of Turkey, and seeds have been widely used in folk medicine, particularly in advanced cancer patients, for a long time.3 In some studies, an anti proliferative effect in prostate cancer, an anti inflammatory effect in chronic inflammatory events such as rheumatoid arthritis, a mitogenic effect on the T lymphocytes, and an antidiuretic and hypotensive effect has been reported.4 It was also reported that UD prevents the toxic effect of carbon tetrachloride on the liver.3 The aim of the present study was to investigate the efficiency of UD on bacterial translocation in an experimental model.Öğe Mean platelet volume in nasal polyps.(2013) Aktaş, Gülali; Şit, Mustafa; Tekçe, Hikmet; Alçelik, Aytekin; Şavlı, Haluk; Şimşek, Tuğçe; Özmen, EvrimMany studies in literature point out that inflammation related to nasal polyp is mostly dependent on eosinophils and their inflammatory products. Beside eosinophils, platelets may have a role in nasal polyp development. Platelets are involved in haemostasis, tissue repairing and inflammation. However, to our knowledge, there are no reports in the literature that study the association between platelet parameters and nasal polyps. Forty-three patients with nasal polyps and forty-nine healthy controls were enrolled in the study, retrospectively. Laboratory data of patients with nasal polyp were obtained at the time of diagnosis. There were no statistically significant differences between the two groups in terms of white blood count, haemoglobin, haematocrit and platelet count. The mean platelet volume (MPV) value of the nasal polyp group was significantly lower than the control group (p = 0.025). Mean eosinophil count was significantly elevated in the nasal polyp group compared to the control group (p < 0.001). Reduction in MPV may be an indicator for nasal polyp formation. Further studies with a larger study population are needed to detect the possible correlation between eosinophil count and MPV values in patients with nasal polyps.Öğe Efficacy of aprotinin treatment on bilateral blunt chest trauma created in rab(2013) Kaya, Halil; Kafalı, Mehmet Ertuğrul; Aydın, Kemal; Koçak, Sedat; Şahin, Mustafa; Gül, Mehmet; Cander, BaşarObjectives: To investigate the effects of aprotinin, on blood gasses, oxidant-antioxidant status, and lung histopathology in an experimental bilateral blunt chest trauma model. Methods: Conducted at the Experimental Animal Laboratory of Meram Medical School at Selcuk University, Konya, Turkey, the study comprised 21 New Zealand female albino rabbits who were divided into three groups. Trauma was applied on the sham and aprotinin groups, which was administered intravenous Aprotinin 20.000 U/kg. Arterial blood samples were obtained from all rabbits at hours 0, 3, 24, and 96. At hour 96 after trauma, all rabbits were sacrificed using the decapitation method, and then blood and lung tissue samples were obtained. Blood nitric oxide, malondialdehyde and blood gas measurements were made. Histopathological changes in the lung were examined with a light microscope. Results: While no positive effect of aprotinin was observed on nitric oxide malondialdehyde and partial pressure of carbon dioxide values, it was seen to have an increasing effect on partial oxygen pressure level. Aprotinin had a partial effect on lung histopathology. Conclusion: Aprotinin was determined to have a positive effect on PO2 levels. We could not find any positive effects especially on alveolar haemorrhage.Öğe Giant ossifying fibroma complicated by mucocele of sphenoid sinus - Case report(2008) Gezici, Ali Rıza; Ergün, Behzat RüçhanOssifying fibroma is a benign tumour that rarely involves the skull. It is most commonly seen in the facial bones with a particular predilection for the mandible. It shares many pathological features with fibrous dysplasia. Ossifying fibroma is an expansive lesion and shows larger non-ossified areas of fibrous tissues. When the tumour is located deeply, encasing the optic-carotid complex, surgical removal becomes difficult because of its ossifying nature. Following surgical resection, the recurrence rate is very low. In the present study, a rare case of giant ossifying fibroma of sphenoid bone which had an intracranial extension with a coexistent mucocele is reported.Öğe Tracheal schwannoma mimicking asthma(Taylor and Francis Ltd., 2024) Afşin, Emine; Yakşi, Osman; Önal, Ali Can; Bacaksız, EmreSchwannoma in primary neurogenic tumors of the trachea is an extremely rare disease. A 21-year-old male patient with stridor was followed up with a diagnosis of asthma for two years. While no lesion was observed in the chest X-ray, tracheal schwannoma was diagnosed in the case who underwent tracheotomy due to the lesion obstructing the trachea almost completely on chest CT. The clinical findings of the patient improved ultimately in the postoperative period. We aimed to discuss the approach and follow-up of the disease with our case, although it is rare that schwannoma might be in the differential diagnosis of masses with upper airway obstruction. © 2022 Informa UK Limited, trading as Taylor & Francis Group.Öğe Extradural posterior inferior cerebellar artery [5] (multiple letters)(2000) Ziyal, İbrahim M.; Salas, E.; Rhoton A.L., Jr.; Fine, A.D.; Cardoso, A.[No abstract available]Öğe Reply: Comparison of two anticoagulants for pain associated with platelet-rich plasma injections(Springer, 2023) Karanfil, Ertuğrul; Doğan, Ali; Görgü, MetinWe read the letter titled ''Comparison of Two Anticoagulants for Pain Associated with Platelet-Rich Plasma Injections'' authored by Pensato et al. in Aesthetic Plastic Surgery. The authors emphasized an important point. PRP treatments have a lot of variables; preparation method, application, amount of PRP injections, and content (such as number of platelet concentration, presence of leucocytes, and pH). However, in our study, we focused on the pain of injections. We showed that there is a pain difference by using different anticoagulants during PRP preparation, but we did not investigate for possible reason of this pain difference. The use of different anticoagulants may have caused changes in the content, and these alterations could be responsible for the variation in pain. Researches could be done to investigate the reason and the physiology of this effect. Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.Öğe Brucellar prosthetic aortic valve endocarditis(Elsevier Science Inc, 2023) Gözdaş, Hasan Tahsin; Şahin, Sultan Beste; Uçaroğlu, Erhan RenanTo the Editor: A 56-year-old man was admitted to the cardiology outpatient clinic with a chief complaint of progressive dyspnea. His past medical history was remarkable for diabetes mellitus, essential hypertension, coronary artery disease, and left hemiplegia due to a cerebrovascular event. He also underwent prosthetic aortic valve replacement 16 years ago.Öğe A chemically induced experimental colitis model with a simple combination of acetic acid and trinitrobenzene sulphonic acid(Aves, 2023) Cinpolat, Havva Yasemin; Buğdaycı, Güler; Şengül, Neriman; Astarcı, Hesna MüzeyyenBackground: It was aimed to induce a new experimental colitis model by using acetic acid and trinitrobenzene sulphonic acid together and to investigate the severity of inflammation biochemically and histopathologically in comparison with other models. Methods: Fifty-six Wistar albino male rats were randomly divided into 4 groups as control, acetic acid, trinitrobenzene sulphonic acid, and combined groups, and the animals were sacrificed following the induction of colitis on the third day and on the seventh day. The serum amyloid A and myeloperoxidase were tested in plasma samples, and the tumor necrosis factor-alpha, interleukin 33, and ST2 were assayed in colon tissue samples with enzyme-linked immunosorbent assay in addition to histopathological examination. Results: There were statistically significant differences between the combined and the control groups both on the third day and on the seventh day in all parameters. There was no difference between the acetic acid group on the seventh day and the control groups in biochemical parameters. Conclusions: The acetic acid model forms acute colitis. The combined model is found to be more successful in forming inflammation when compared to other models.
