Port-wine stain, laser therapy and pregnancy: Risk factors for multiple pyogenic granulomas?

Pyogenic granuloma (PG) and port-wine stain (PWS) are an acquired vascular tumour and a congenital malformation, respectively. A 35-year-old woman presented at 8 months’ gestation with a 1-month history of enlarging masses on the congenital lesion of the face. A congenital purple macular lesion limited to the right side of the face was found to be consistent with PWS. In addition, four red papules 26 mm in diameter were localized to PWS areas excluding normal skin (fig. 1). Spontaneous or post-traumatic bleeding history was denied. There was no oral or nasal lesion. Neurological and ophthalmological examinations were all normal. The patient had undergone five sessions of laser therapy 6 years earlier. She denied similar lesions during her first pregnancy 9 years ago.