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Öğe Verrüköz diskeratom(Deri Zührevi Hastalıklar Derneği, 2008) Anul, Hüseyin; Alper, Murat; Kavak, Ayşe; Suna, MazlumeWarty dyskeratoma is a benign dermatose that is characterized by a soliter papule or a nodule. Clinical findings are similar to verruca vulgaris, irritated seboreik keratoses and hypertrophic actinic keratoses. A 31-year-old woman with a 5 years duration of a purple-brown colored papule with a crust formation at the central, in 3 mm diameter, on the malar region. Histopathological findings were found resembling to warty dyskeratoma. This condition is rare and is presented with its demonstrative properties in the light of literature data. (Turkderm 2008; 42: 26-7)Öğe Analysis of holo-transcobalamin (active vitamin B12) in the sera of patients with chronic viral hepatitis(Galenos Yayıncılık, 2010) Sırmatel, Fatma; Sırmatel, Öcal; Buğdaycı, Güler; Eriş, Fatma Nur; Dinçer, SevimIn chronic viral hepatitis, when early hepatic necrosis and viral replication are defined, progression of hepatic necroinflammation can be terminated and cirrhosis can be prevented by therapy. In chronic hepatic failure, an increase in the blood levels of vitamin B12 is observed as a result of vascular leakage. From this perspective, in cases with chronic viral hepatitis B (HBV) and chronic viral hepatitis C (HCV), the indicator of serum active vitamin B12, namely holo-transcobalamin II (Holo-TCII), is interpreted as an indicator of hepatocellular damage prior to treatment. The aim of this study is to evaluate the value of serum Holo-TCII in the diagnosis of hepatic failure and hepatocellulardamage in chronic viral hepatitis. In a university hospital, Holo-TCII, the best indicator of serum vitamin B12, was analyzed in the sera of 127 healthy blood donors and in 274 patients with chronic viral hepatitis (127 HBV patients and 17 HCV patients), who were clinically, serologically and histologically diagnosed. Age distribution of the patients ranged between 18 and 70 years. Serum samples of the patients with chronic viral hepatitis were collected before therapy and kept at -20 degrees C until use. When determining the study group, the patients with decompensated cirrhosis, any cardiac, metabolic, hematologic, gastrointestinal and autoimmune disorderswere excluded. As the control group, healthy blood donors without metabolic, cardiovascular, gastrointestinal and hematologic diseases were chosen; age and gender distributions were also considered to be parallel with the patient group. Analyses were performed with commercially available Holo-TCII kits according to the prospectus, using macro enzyme immunoassay method (EIA) method. Results were statistically compared between the groups. In our study, no difference was determined in terms of holo-TCII levels between chronic HBV (42.07 pmol/L) and HCV patients (42.8 pmol/L), whereas the results of the HBV and HCV patients were found to be significantly higher compared to the control group (25.7 pmol/L, p< 0.017). Holo-TCII can be used as the earliest symptom of cellular damage, particularly in patients with chronic viral hepatitis. Further studies on chronic hepatic failure and cellular damage may also provide information that Holo-TCII can be used as a diagnostic criterion.Öğe The relationship of vitamin D levels with hemogram indices and metabolic parameters in patients with type 2 diabetes mellitus(Amer Inst Mathematical Sciences-Aims, 2024) Başaran, Elif; Aktaş, GülaliBackground: Vitamin D deficiency and Type 2 Diabetes (T2DM) are two important health problems that have rapidly increased prevalences in recent years. Chronic inflammation and susceptibility to infection are the characteristic features of T2DM. Vitamin D deficiency has been associated with high serum inflammatory marker levels due to its immunomodulatory effect. Moreover, studies have pointed out that vitamin D insufficiency could be associated with T2DM. Additionally, in recent years, inflammatory markers derived from hemogram have been associated with diabetes and its complications. Therefore, in our study, vitamin D levels, metabolic markers (i.e., serum uric acid, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol), and hemogram indices were analyzed in well controlled and poorly controlled T2DM patients. Furthermore, we compared those variables in vitamin D deficient and non-deficient groups. Methods: Laboratory data, including vitamin D and hemogram markers, were compared between poorly and well controlled T2DM patients who visited the outpatient internal medicine clinics of our institution. Results: A total of 240 T2DM individuals were included in the present study: 170 individuals had vitamin D deficiency and 70 individuals had normal vitamin D levels, who served as controls. The median neutrophil to lymphocyte ratio (NLR) value was 2.2 (0.74-7.4) in the vitamin D deficient group and 2.02 (0.73-5.56) in the vitamin D normal group (p = 0.025). Among the study parameters, the NLR and glycated hemoglobin (HbA1c) levels showed a significant positive correlation (r = 0.30, p < 0.001). The sensitivity and specificity of the NLR to predict vitamin D deficiency were determined as 60% and 49%, respectively (AUC: 0.59, p = 0.03, 95% CI: 0.51-0.67). The sensitivity and specificity of the NLR to predict an improved control of diabetes were 72% and 45%, respectively (AUC: 0.67, p < 0.001, 95% CI: 0.60-0.74). Conclusions: We think that NLR can be helpful in follow up of T2DM and vitamin D deficiency.Öğe Serum C-reactive protein to albumin ratio as a reliable marker of diabetic neuropathy in type 2 diabetes mellitus(Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, 2024) Aktaş, GülaliIn various diseases characterized by inflammation, the C-reactive protein to albumin ratio (CAR) serves as a marker of inflammation. Type 2 diabetes mellitus (T2DM) is frequently complicated by diabetic neuropathy (DN) and timely diagnosis is crucial for treatment and potential reversal of this complication. Since both DN and T2DM are associated with chronic, low-grade inflammation, our study aimed to evaluate CAR levels in type 2 diabetic subjects with DN and compare them to those in subjects without DN. Patients presenting to our institutional outpatient clinics were divided into two groups based on the presence of DN. Data on characteristics and laboratory measures, including CAR,were compared between the DN and non-DN groups. The median CAR in the DN and non-DN groups was 2.19% (range 0.2%-49%) and 0.56% (range 0.02%-5.8%), respectively (P < 0.001). CAR showed significant positive correlations with weight (r = 0.19, P = 0.01), body mass index (BMI) (r = 0.11, P = 0.03), waist circumference (r = 0.10, P = 0.046), fasting glucose (r = 0.14, P = 0.004), serum creatinine (r = 0.25, P < 0.001), triglyceride (r = 0.17, P < 0.001), and LDL-cholesterol (r = 0.13, P = 0.001) levels, and an inverse correlation with estimated glomerular filtration rate (eGFR) (r = -0.16, P < 0.001). Additionally, CAR demonstrated a sensitivity of 78% and specificity of 73% for predicting DN at a threshold of 1.02% (area under curve [AUC] 0.84, 95% confidence interval [CI] 0.82-0.87, P < 0.001). High CAR levels were independently associated with an increased risk of DN (odds ratio [OR] 1.34, 95% CI 1.08-1.62, P < 0.001). Elevated CAR levels may thus be considered a potential marker for DN in T2DM patients.Öğe Controlling Nutritional Status (CONUT) score is a novel marker of type 2 diabetes mellitus and diabetic microvascular complications(Taylor & Francis Ltd, 2024) Aktaş, Gülali; Duman, Tuba Taslamacıoğlu; Tel, Burçin AtakObjectives: Type 2 diabetes mellitus (T2DM) and its microvascular complications are characterized by chronic inflammation. The Controlling Nutritional Status (CONUT) score is a tool used to assess nutritional status and is often associated indirectly with inflammatory processes. We aimed to compare the CONUT scores of T2DM patients with those of healthy volunteers and to compare T2DM patients with and without microvascular complications. Methods: Patients diagnosed with T2DM and healthy volunteers (as controls) were included in the study. The CONUT score is calculated using the following formula: serum albumin score + total cholesterol score + total lymphocyte count score. CONUT scores of T2DM patients and healthy controls, as well as those of diabetics with and without microvascular complications, were compared. Results: The CONUT scores of the T2DM and control groups were (1 [0-7]) and (0 [0-2]), respectively (p < 0.001). The sensitivity and specificity of the CONUT score (<1.5 threshold) in detecting T2DM were 43% and 90%, respectively (AUC: 0.67, p < 0.001, 95% CI: 0.64-0.71). Moreover, the CONUT score was an independent risk factor for T2DM (OR: 0.34, p < 0.001, 95% CI: 0.22-0.52). The CONUT score of T2DM patients with microvascular complications (2 [0-7]) was significantly higher than that of T2DM patients without microvascular complications (0 [0-4]) and control subjects (0 [0-2]) (p < 0.001). A CONUT score higher than 1.5 had 83% sensitivity and 92% specificity in detecting T2DM with microvascular complications (AUC: 0.91, p < 0.001, 95% CI: 0.89-0.93). Conclusion: The CONUT score could be useful in detecting diabetic microvascular complications in clinical practice, as it is an inexpensive and easy-to-assess marker.Öğe Mean platelet volume increases in type 2 diabetes mellitus independent of HBA1C level(Carbone Editore, 2014) Çakır, Lütfullah; Aktaş, Gülali; Enginyurt, Özgür; Çakır, Şahika AltasAims: Diabetes mellitus is an important health problem worldwide and associated with subclinical inflammation. Several inflammatory markers have been studied in these conditions. Mean platelet volume and red cell distribution width are hemogram parameters that are suggested to be related with inflammation. We aimed to study hemogram parameters of type 2 diabetic patients, and compare to healthy subjects, retrospectively. Methods: We included patients with type 2 diabetes mellitus in this retrospective study. Healthy subjects admitted to our institution for a routine check-up were included as control group. Laboratory data such as, white blood cell count (WBC), hemoglobin (Hb), red cell distribution width (RDW), platelet count (PLT) and mean platelet volume (MPV) and concomitant HbA1c values of the participants recorded. Results: We could not found a significant difference in RDW levels between groups. On the other hand, MPV was significantly elevated in study group compared to control subjects. Conclusion: We suggest that MPV is associated with type 2 diabetes mellitus. Prospective studies with a larger cohort are necessity to define the relationship of MPV and the level of metabolic control.Öğe Ultrasound prediction of spontaneous abortions in live embryos in the first trimester(Modestum Ltd, 2016) Alptekin, Hüsnü; Acar, Türker; Işık, Hatice; Cengiz, TürkanObjective: To generate a prediction model for miscarriage in women with a viable single pregnancy from first-trimester ultrasound findings and maternal characteristics. Methods: A prospective, cross-sectional study of 415 singleton pregnancies was performed. The initial ultrasound parameters were crown-rump length (CRL), mean gestational sac diameter (MGSD), yolk sac diameter (YSD), and the sum of the differences between gestational ages and embryonic heart rate (EHR). Potential predictors for spontaneous miscarriage occurring prior to 20 weeks were evaluated. Results: Fifty-three (12.8%) patients had miscarriages and 362 (87.2%) had normal outcomes. Forty-three (81.2%) miscarriages occurred in the first trimester, 5 (9.4%) in the second trimester, and 5 (9.4%) represented fetal anomalies. EHR, CRL, and MGSD were decreased in the miscarriage group (p<0.001); YSD showed no difference (p=0.21). Gestational age by CRL and by MGSD were different between the groups (p<0.001). The proposed sum of differences was higher in the miscarriage group (p<0.001). Maternal age, indication for scan, gestational age by MGSD and CRL, heart rate, and proposed sum of differences were found to be potential predictors. Predictive ability of our proposed model was calculated sensitivity as 0.509, and specificity as 0.975 with a cut-off=0.5. The prediction model's false positive rate is 0.025, and its false negative rate is 0.491. Conclusions: Miscarriage can be predicted via maternal characteristics and ultrasound findings. Advancing maternal age, low EHR, and high proposed sum of differences increase the probability of miscarriage.Öğe Comparison of fusidic acid susceptibility of staphylococci: A multicenter study(Carbone Editore, 2018) Çetinkol, Yeliz; Aladal, Murat; Ünal, Nevzat; Bayramoğlu, Gülçin; Ahmetbayık, Seyit; Doğan, Metin; Durmaz, SüleymanIntroduction: The increasing antibiotic resistance of staphylococci, an important factor among societal and hospital-sourced infection factors, reduces the treatment choices available. Fusidic acid (FA), the use of which has recently come to the agenda again, is thought to form a new alternative treatment for staphylococci infections. The aim of our study is to identify the FA resistance situation at certain centers compared to generally increasing antibiotic resistance, to present epidemiological data on new antibiotherapy methods and to aid in treatment planning. Materials and methods: With this aim we determined and compared the susceptibility of 2018 Staphylococcus aureus and 5242 Coagulase negative Staphylococci strains obtained at 11 centers in different regions of our country against FA, oxacillin, penicillin, trimethoprim-sulfamethoxazole and ciprofloxacin. Results: The Coagulase negative Staphylococci strains were determined to be more resistant to all antibiotics compared to S. aureus strains. When the means of all centers are examined, FA resistance was found in 7.1% of S. aureus strains and 55.1% of Coagulase negative Staphylococci strains. Of all antibiotics for both S. aureus and Coagulase negative Staphylococci strains the antibiotic that strains were most susceptible to was trimethoprim-sulfamethoxazole, while the antibiotic that most were resistant to was penicillin. Conclusion: In light of these findings, with high susceptibility of 92.9% for S. aureus strains to FA, it appears to be a good alternative treatment choice for S. aureus infections. Due to high resistance rates of methicillin-resistant Coagulase negative Staphylococci sourced infections, before treatment it is necessary to perform an antibiotic susceptibility test. We believe that broader scale and more comprehensive studies will provide guidance in planning treatment.Öğe Cytokine expression profiles in children and adolescents with tic disorders(Nature Portfolio, 2024) Kütük, Meryem Özlem; Tufan, Ali Evren; Kılıçaslan, Fethiye; Gökçen, Cem; Aksu, Gülen Güler; Yektaş, Çiğdem; Kandemir, HasanThe etiology of tic disorders (TDs) is not precisely known, although several lines of evidence suggest involvement of the immune system in pathogenesis. Here, we aimed to determine the expression levels of pro-inflammatory and anti-inflammatory cytokines in children with TD and compare them with those of healthy controls. Furthermore, we also evaluated their association with clinical variables in the TD group. Within the study period, 88 children with tic disorders and 111 healthy control children were enrolled. Most children with tic disorders were diagnosed with Tourette's disorder (n = 47, 53.4%) or persistent motor tic disorder (n = 39, 44.3%), while the remainder (n = 2, 2.3%) were diagnosed with persistent vocal tic disorder. We found that children with tic disorders had significantly elevated levels of IL-1 beta, TNF-alpha, IL-6 and IL-4 expression, while we detected lower expression levels of IL-17 in children with tic disorders. Our findings provide a molecular landscape of cytokine expression in children with TD, which may suggest a proinflammatory state not affected by the presence of comorbidity and symptom severity. Delineating the contribution of alterations in the immune system to the pathogenesis of tic disorders may pave the way for better therapeutic interventions.Öğe Evaluation of total oxidative level and total antioxidant capacity in cases with chronic viral hepatitis(Aves, 2009) Sırmatel, Fatma; Duygu, Fazilet; Çelik, Hakim; Selek, Şahabettin; Sırmatel, Öcal; Gürsoy, Bensu; Eriş, Fatma NurObjective: Oxidative stress is described as an instability between production of free radicals from cells and antioxidant defence of the body. The aim of the study was to investigate the correlation of total antioxidant capacity (TAC) and total oxidative level (TOL) with the severity of the disease and reliability of these parameters in the follow up of response to treatment in cases with chronic viral hepatitis (CVH). Methods: Between January 2004-March 2006, 73 cases with CVH were included in the study. The ages of the patients ranged from 15 to 70 years. Diagnosis of CVH was confirmed by clinical serological, and biochemical markers. The cases were divided into two groups: Group 1 as HBsAg-positive or anti-HCV-positive but HBV DNA or HCV RNA-negative and Group 2 as proven CVH. TAC, lipid hydroperoxide (LOOH), and TOL of the sera were studied according to Erel method, and statistically evaluated by 2 test in all the cases. Results: TAC, LOOH and TOL were found statistically significantly different between two groups. Average values of TAC were 1.8 +/- 0.5 mmol Trolox-Eqv./L and 1.0 +/- 0.15 mmol Trolox-Eqv./L in Group 1 and Group 2 (p=0.0001) respectively. Average values of LOOH were 5.3 +/- 2.8 mu mol H2O2 in Group 1 and 10.6 +/- 10.1 mu mol H2O2 in Group 2 (p=0.002). Average values of TOL were 10.2 +/- 5.9 mu mol H2O2 Eqv./L in Group 1 and 18.5 +/- 16.6 mu mol H2O2 Eqv./L in Group 2 (p=0.004). Conclusions: TAC was found higher, and TOL and LOOH were found lower in Group 1 than Group 2. The evaluation of plasma TAC, TOS ve LOOH levels may be important activation markers for the follow up of CVH.Öğe Treatment outcomes and affecting factors in tuberculosis patients in Istanbul Eyup struggle dispensary(Bilimsel Tıp Publishing House, 2007) Talay, Fahrettin; Kümbetli, ŞenolThe aim of this study was to evaluate the outcomes of the therapy applied, and affecting factors, in tuberculosis patients. Demographic data, microbiological results, radiological properties, and therapy outcomes of 253 tuberculosis patients, who had been treated and followed between 2001 and 2002 in istanbul Eyup Struggle Dispensary, were analyzed, and factors that might have affected the outcomes were detected. Mean age of patients was 32.0 +/- 14.4, and 74 of them were female, 179 were male. The success of treatment was 92%, and cure rate was 83%. No relation was found between the treatment success and age group, marital status, history of contact, being old patient or new patient, and hospitalization. A negative relation was found between the success of treatment and male gender, smoking, educational status of primary school and lower, retreatment of defaulter, rifampicin resistance, and presence of cavity in pretreatment radiological appearance (p < 0.05). According to the logistic regression multivariate analysis, rifampicin resistance was the only factor that negatively affected the success of the treatment [OR=15.9 (95% CI 2.2-117.4]. As a result, the desired rate of treatment success and cure rate had been achieved in tuberculosis patients in this particular dispensary. Treatment success is negatively affected by rifampicin resistance. We conclude that, more careful analysis and follow up all patients with directly observed treatment may increase the treatment success and cure rate.Öğe Tularemi: Türkiye’de servikal lenfadenopatinin beklenmeyen ancak yaygın bir nedeni. Olgu sunumu ve literatür derlemesi(Galenos Yayıncılık, 2008) Karabay, Oğuz; Yılmaz, Fahrettin; Gürcan, ŞabanA man who had tonsillopharyngitis and lymphadenomegaly has been admitted to our outpatient clinic. His complaints had been unresponsive to various beta-lactam antibiotics treatments in this period. In this paper, we report a tularemia case and review of the current literature.Öğe Impaired immunity against tetanus in Type 2 Diabetes(Int Scientific Information, Inc, 2005) Tamer, Ali; Karabay, Oğuz; Ekerbiçer, Hasan; Tahtaci, Mustafa; Selam, Belgin; Çelebi, HarikaBackground: The aim of this study was to compare serum levels of tetanus antibody in diabetic patients over 50 years of age with those of age-and sex-matched non-diabetic controls. Material/Methods: The study population consisted of 115 type 2 diabetic patients and 115 age-and sex-matched nondiabetic patients. Serum levels of tetanus IgG were measured by a commercial ELISA kit, and levels over 0.1 IU/ml were considered protective. Results: Mean serum levels of tetanus antibody in the diabetic and control groups were 0.164 +/- 0.140 IU/ml vs. 0.374 +/- 0.534 IU/ml, respectively (p < 0.001). Mean serum levels of tetanus antibody in the diabetics vs. controls aged 50-64 years were 0.172 +/- 0.141 IU/ml vs. 0.568 +/- 0.653 IU/ml and in those >= 65 years 0.151 +/- 0.139 IU/ml vs. 0.154 +/- 0.193 IU/ml, respectively (p < 0.001, p=1.000). Among patients aged 50-64 years, 38 (55.9%) cases in the diabetic and 45 (73.8%) in the control group demonstrated protective levels of tetanus antibodies (p=0.034). Of patients >= 65 years, 24 (51.1%) cases in the diabetic and 22 (40.7%) in the control group had protective levels of tetanus antibodies (p=0.298). Conclusions: Serum levels of tetanus antibody decreased in diabetic patients older than 50 years of age, whereas this period of time is prolonged to 65 years in healthy individuals. All individuals over 65 years should be vaccinated against tetanus; however, vaccination over 50 years of age might be considered for diabetic patients.Öğe The evaluation of the cochlear aqueduct and internal acoustic canal in patients with unilateral subjective tinnitus and normal hearing(Aves, 2023) Yılmazsoy, Yunus; Muluk, Nuray Bayar; Özdemir, Adnan; Şencan, ZiyaObjective: We investigated the relationship between idiopathic subjective tinnitus and internal acoustic canal, cochlear aqueduct, vestibule, and lateral semicircular canal measurements by temporal magnetic resonance imaging. Methods: In this retrospective study, temporal magnetic resonance imaging sections of 25 patients (8 males and 17 females) with unilateral tinnitus and normal hearing were included. The internal acoustic canal, cochlear aqueduct, vestibule, and lateral semicircular canal measurements and internal acoustic canal and cochlear aqueduct shape classification were determined in the ipsilateral tinnitus side and contralateral non-tinnitus side. Results: The cochlear aqueduct length and width and internal acoustic canal opening width, length, width, and area of the ipsilateral tinnitus side were not different from the contralateral side. Similarly, the vestibule area and lateral semicircular canal height and width values were not different between the ipsilateral tinnitus side and the contralateral side. The main cochlear aqueduct type was type 2 in both ipsilateral and contralateral sides. For the internal acoustic canal types, cylindrical and funnel shapes were the most common types for the ipsilateral tinnitus side and contralateral side. There were positive correlations between the internal acoustic canal and vestibule areas; cochlear aqueduct length and internal acoustic canal areas; cochlear aqueduct width and width of the lateral semicircular canal; internal acoustic canal area and length and cochlear aqueduct length; internal acoustic canal opening width and height of the lateral semicircular canal; and width of the lateral semicircular canal dimensions. In older patients, the ipsilateral internal acoustic canal area was found to be smaller. Conclusions: In idiopathic subjective tinnitus, there were no important pathologies detected in the internal acoustic canal, cochlear aqueduct, vestibule area, and lateral semicircular canal. We concluded that there are no statistically significant morphometric differences compared to the healthy side in the internal acoustic canal, cochlear aqueduct, vestibule, and lateral semicircular canal areas detected by temporal magnetic resonance imaging in patients with unilateral subjective tinnitus and normal hearing.Öğe The effect of the tarsal joint positions on the tibial nerve motor action potential latency in dog: Electrophysiological and anatomical studies(M H Schaper Gmbh Co Kg, 2007) Turan, Erkut; Bölükbaşı, O.; Ömeroğlu, Sabri AlpThis study has been carried out to determine the effect of neutral position, hyperextension and hyperflexion of the tarsal joint on the tibial nerve, motor action potential latency and tarsal canal compartment pressure in dogs with the aid of electrophysiological and anatomical methods. Totally twenty healthy mongrel dogs were used. Latency of motor nerve action potential (MNAPL) studies of tibial nerve via surface stimulating and needle recording electrodes was performed on right hind limbs of all the dogs. The compartment pressures of the tarsal canal with the pressure transducer were determined from both limbs from ten of the dogs. In one dog, tarsal regions of both left and right limbs were demonstrated using magnetic resonance imaging (MRI). Two dogs were euthanatized and tarsal regions of the dogs were sectioned for correlative anatomy. Nerve conduction studies showed that the MNAP latency of the tibial nerve were 3.55 +/- 0.097 ms, 3.76 +/- 0.087 ms and 3.39 +/- 0.097 ms in neutral, hyperextension and hyperflexion positions, respectively. Hyperflexion of the tarsal joint caused prolongation of the MNAP latency of the tibial nerve with the highest pressure value being determined in tarsal canal. From the anatomical viewpoint, the distance between the flexor hallucis longus muscle and the superficial digital muscle was the shortest during hyperflexion and the plantar branch of saphenous artery, lateral and medial plantar nerves located more laterally in cadaver and MR imaging sections. As a result of this study, it is thought that tarsal region diseases as well as long time splint in the hyperflexion position as applied in the Ehmer sling can affect the compartment pressure and nerve tension because of occupying in the tarsal canal. Raising pressure and nerve stretching in the tarsal canal compartment could cause deficiencies in the conduction velocity of the tibial nerve. This might be a result of tarsal tunnel syndrome in the dog. Clinicians could consider this syndrome in cases of tarsal region diseases as well as application of long time splint in hyperflexion of tarsal joints in dogs.Öğe Traumatic dissecting aneurysm of superficial temporal artery: A case report(Derman Medical Publ, 2014) Gezici, Ali Rıza; Dağıstan, Yaşar; Güler, Kamil; Dağıstan, Emine; Özkan, NezihTraumatic aneurysms of the superficial temporal artery (STA) are a rare occurrence. Here, we report a very rare case of dissecting aneurysm of superficial temporal artery caused by blunt trauma. 22 year man, admitted with a solitary painless, pulsatile swelling in the right temporal region. 8 mounts ago, he had closed head injury over right temporal region without a skull fracture. A traumatic aneurysm of the STA was diagnosed. Under anesthesia, the aneurysm was completely excised.Öğe Thickness of anterior sclera and corneal layers in systemic sclerosis(Springer, 2024) Ün, Emine Şeker; Pekel, Gökhan; Taşçı, Murat; Bahar, Alperen; Pekel, Evre; Çetin, Ebru Nevin; Subaşı, MustafaPurpose To evaluate the thickness of anterior sclera and corneal layers in patients with systemic sclerosis. Methods The present cross-sectional study included 41 patients with systemic sclerosis and 41 age- and gender-matched healthy controls. The study and control groups were compared in terms of the thickness of anterior sclera, corneal epithelium, Bowman's layer, corneal stroma, and Descemet's membrane-endothelium complex. The thickness measurements were obtained using the anterior segment module of spectral-domain optical coherence tomography. Results The thickness of anterior sclera, corneal epithelium, Bowman's layer, and Descemet's membrane-endothelium complex were similar in the patients with systemic sclerosis and healthy controls (P > 0.05). Total corneal thickness at the apex was 511.1 +/- 33.5 mu m in the systemic sclerosis group and 528.4 +/- 29.5 mu m in the control group (P = 0.015). The corneal stroma was thinner in the systemic sclerosis patients compared to the healthy controls (P = 0.02). Conclusions The corneal stroma was thinner in the patients with systemic sclerosis compared to that of healthy controls, while the thickness of the anterior sclera was similar in both groups.Öğe Cardiac tamponade with primary certain non-malignancy in clinic: Case report(Düzce Univ, 2014) Duran, Arif; Ocak, Tarık; Üyetürk, Ümmügül; Erdem, Alim; Önder, Hüsnü; Maltaş, Mehmet ŞakirCardiac tamponade is a major life threatening condition characterized with accumulation of fluid in pericardial cavity which prevents heart contractions. Etiology includes trauma, renal failure, myocardial infarction, cardiovascular surgery, coronary angiography, and malignancies. Clinical signs vary depending on the development rate of tamponade. Malignancy related tamponade is caused by different factors that associated with the type and the extension of malignancy. We present a patient who admitted to our emergency department with cardiac tamponade caused by a malignancy of an unknown primaryÖğe Systemic immune-inflammation index as a novel hematological marker for predicting the recurrence of deep venous thrombosis(Sage Publications Ltd, 2024) Dönmez, İbrahim; Müdüroğlu, AyhanObjective To determine whether there was a possible predictive relationship between systemic immune-inflammation index (SII) and recurrence of deep venous thrombosis (DVT).Methods A total of 231 patients with DVT who met the study criteria and whose data could be accessed were enrolled to this retrospective single-centered cross-sectional study. Of them 26 patients with DVT recurrence consisted of the study group (Group 1) while remaining 205 cases without recurrence were considered as the control population (Group 2). The patients' basic clinical features and laboratory results from the complete blood count (CBC) test were recorded and compared between groups. Following univariate analyses, a multivariate logistic regression analysis was performed to identify the independent predictors of the recurrence of DVT. Additionally, a receiver-operating characteristic (ROC) curve analysis was performed to detect the cut-off values of the predictors with sensitivity and specificity rates.Results There were no significant differences between the groups for basic clinical features, except for diabetes mellitus, pulmonary embolism, and atrial fibrillation. Although the univariate analysis revealed that the median values of NLR, PLR, and SII were significantly higher in the DVT recurrence group, only SII was determined to be a significant and independent predictor of DVT recurrence in the multivariate logistic regression analysis. According to ROC curve analysis, SII of 1685 x 103/mm3 constituted the cut-off value for predicting DVT recurrence with 61.5% sensitivity and 76.6% specificity (AUC = 0.686, p = .001).Conclusion The present study demonstrated for the first time in the literature that SII significantly predicted the recurrence of DVT.Öğe Evaluation of the relationship between computed tomography angiography collateral scores and clinical outcome(Assoc Arquivos Neuro- Psiquiatria, 2024) Yabalak, Ahmet; Ögün, Muhammed Nur; Önalan, Ayşenur; Yılmaz, Murat; Tokmak, Hilmiye; Ersoy, Sadettin; Bilgili, FatmaBackground The relationship between collateral circulation and prognosis after endovascular treatment in anterior circulation strokes has been reported in many studies. Objective In this study, we aimed to compare the predictive power of clinical outcome by comparing five different collateral scores that are frequently used. Methods Among the patients who underwent endovascular treatment in our clinic between November 2019 and December 2021, patients with premorbid mRS < 3, intracranial ICA and/or MCA M1 occlusion, and a pre-procedural multiphase CTA examination were included in the study. Demographic, technical, and duration information about the procedure, major events after the procedure, and clinical outcomes at 3 months were recorded. The mCTA, Tan, Maas, Miteff, and rLMC collateral scores of the patients were evaluated. Results Clinical outcome at 3 months were good in 37 of the 68 patients included in the study (mRS <= 2). Only the mCTA and rLMC collateral scores were statistically significantly higher in those with a good clinical outcome. Significant correlation with 3-month mRS was detected only in mCTA and rLMC scores. Although rLMC and mCTA collateral scores showed a statistically significant association with prognosis, they were not sufficient to be an independent predictor of prognosis. Conclusion mCTA and rLMC were found to have the highest predictive power of clinical outcome and the highest correlation with the 3-month clinical outcome. Our study suggests that it would be beneficial to develop a new scoring system over multiphase CTA, which combines regional and temporal evaluation, which are the strengths of both collateral scoring.
