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Öğe The relationship between nitrate-induced headache and -blood viscosity: An observational prospective study(Lippincott Williams & Wilkins, 2023) Toprak, Kenan; Kaplangoray, Mustafa; Memioğlu, Tolga; İnanır, Mehmet; Biçer, Asuman; Demirbağ, Recep; Erdoğdu, HamzaNitrates are one of the most prescribed medications in the treatment of angina pectoris today. Headache is the most common side effect of nitrates, and there is limited prospective data on the determinants of this effect. Our aim in this study is to open a foresight window for clinicians in clinical practice by explaining the possible relationship between nitrate-induced headache and whole-blood viscosity (WBV). After coronary revascularization treatment, 869 patients with angina who were prescribed nitrate preparations were divided into groups according to the development of headache or not and categorized according to the 4-grade scale level. Those who had no headache during nitrate use were graded as grade 0, those who felt mild headache were grade 1, those who felt moderate headache were grade 2, and those who described severe headache were graded as grade 3. The groups were compared according to WBV values. A total of 869 participants were included in the study. Most patients (82.1%) experienced some level of headache. Headache severity correlated with both WBV at high shear rate (r = 0.657; P < 0.001) and WBV at low shear rate (r = 0.687; P < 0.001). In multivariate analysis, WBV was determined as an independent predictor of headache experience. WBV predicted nitrate-induced headache with 75% sensitivity and 75% specificity at high shear rate and 77% sensitivity and 77% specificity at low shear rate. WBV seems to be one of the major determinants for nitrate-induced headache. WBV may be a guide for initiating alternative antianginal drugs without prescribing nitrates to the patient to increase patient compliance.Öğe Electrophysiologic and anti-inflammatorial effects of cyclooxygenase inhibition in epileptiform activity(Wiley, 2023) Türel, Canan Akünal; Çelik, Hümeyra; Çetinkaya, Ayhan; Türel, İdrisThe aim of our study is to investigate the electrophysiological and anti-inflammatory effects of diclofenac potassium on epileptiform activity, which is the liquid form of diclofenac, and frequently used clinically for inflammatory process by inhibiting cyclooxygenase enzyme (COX). Wistar rats aged 2-4 months were divided into Epilepsy, Diazepam, Diclofenac potassium, and Diazepam+diclofenac potassium groups. Diazepam and diclofenac potassium were administered intraperitoneally 30 min after the epileptiform activity was created with penicillin injected intracortically under anesthesia. After the electrophysiological recording was taken in the cortex for 125 min, interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) were evaluated by the ELISA in the serums. No change was observed between the groups in serum IL-1 beta, IL-6, and TNF-alpha values. It was observed that the co-administration of diclofenac potassium and diazepam at 51-55, 56-60, 61-65, 111-115, and 116-120 min was more effective in reducing spike amplitude than diclofenac potassium alone (p < 0.05). Single-dose diclofenac potassium did not have an anti-inflammatory effect in epileptiform activity but both diazepam and diclofenac potassium reduced the epileptiform activity.Öğe The prevalence of vitamin D deficiency and the factors affecting vitamin D levels in children admitted to the outpatient clinic of pediatric endocrinology in Bolu province(Elsevier France-Editions Scientifiques Medicales Elsevier, 2023) Kılınç, Yasemin Baranoğlu; Bolu, SemihBackground: The present study aimed to determine the rate of vitamin D deficiency in children who presented to the pediatric endocrinology outpatient clinic in Bolu and to investigate the factors affecting vitamin D levels.Methods: Vitamin D levels of 1008 children and adolescents were retrospectively analyzed according to age group (0-1, 1-10, and 10-18 years), gender, season, month, obesity and other diseases, and deficiency category. Moreover, calcium, phosphorus, alkaline phosphatase, and parathyroid hormone levels were evaluated. Comparisons and correlation analyses between related groups were performed.Results: The mean vitamin D level of the patients was 16.35 +/- 9.56 ng/mL and was lower in girls (14.90 +/- 9.56 ng/mL) than in boys (18.68 +/- 9.63 ng/mL, p<0.001). Overall, 18.3% of the children and adolescents had vitamin D insufficiency, 52.3% had vitamin D deficiency, and 3.5% had severe vitamin D deficiency. Vitamin D levels were lower in 10-18-year age group than in the other age groups (p<0.001), and levels were higher in summer and autumn than in winter and spring (p<0.001). Vitamin D levels of participants with obesity (14.3 +/- 8.3 ng/mL) were significantly lower than normal-weight participants with no health problems (15.9 +/- 8.3 ng/mL, p = 0.004). There was a negative correlation between vitamin D, alkaline phosphatase, and parathyroid hormone levels in the 1-10-year age group, but a positive correlation between vitamin D, alkaline phosphatase, and calcium levels in the 10-18-year age group.Conclusion: The rate of vitamin D deficiency is high among children and adolescents who presented to the endocrine outpatient clinic in Bolu. The season appears to be an important factor affecting vitamin D levels as well as the relationship between vitamin D and parathyroid hormone. Obese children and adolescents living in this region may be advised to take vitamin D supplements in winter and spring.Öğe Could zonulin and presepsin be biomarkers and therapeutic targets for acute myocarditis?(Arquivos Brasileiros Cardiologia, 2023) Toprak, Kenan; İnanır, Mehmet; Memioğlu, Tolga; Kaplangöray, Mustafa; Palice, Ali; Taşcanov, Mustafa BeğençBackground: The diagnosis of acute myocarditis is usually made with clinical and laboratory parameters. This can sometimes be mixed up with diseases that have similar clinical features, making the diagnosis difficult. Therefore, the use of more specific biomarkers, in addition to the classically used biomarkers such as troponin, will accelerate the diagnosis. In addition, these biomarkers may help us to understand the mechanism of myocarditis development and thus predict unpredictable clinical outcomes.Objective: This study aims to reveal the possible relationship between intestinal permeability and acute myocarditis.Methods: In this study, we wanted to evaluate serum levels of zonulin and presepsin in 138 consecutive subjects, including 68 patients with myocarditis and another 70 as the control group, matched for age, gender, and cardiovascular risk factors. P-values <0.05 were considered to be statistically significant.Results: Compared to the control group, zonulin and presepsin were significantly higher in the patient group with myocarditis (p < 0.001, for all). Zonulin levels were positively correlated with presepsin, peak CK-MB, and peak troponin levels (r = 0.461, p < 0.001; r = 0.744, p < 0.001; r = 0.627, p < 0.001; respectively). In regression analysis, presepsin and zonulin were determined as independent predictors for myocarditis (OR 1.002, 95% CI 1.001-1.003, p = 0.025; OR 12.331, 95% CI 4.261-35.689; p < 0.001; respectively). The predictive value of acute myocarditis of presepsin and zonulin in ROC curve analysis was statistically significant (p < 0.001, for both).Conclusion: This study showed that zonulin and presepsin could be biomarkers that can be used in the diagnosis of myocarditis, and they can also be therapeutic targets by shedding light on the developmental mechanism of myocarditis.Öğe How effective is the systemic inflammatory immune index in the etiopathogenesis of isolated coronary artery ectasia?(Arquivos Brasileiros Cardiologia, 2023) Toprak, Kenan; Kaplangöray, Mustafa; İnanir, Mehmet; Memioğlu, TolgaIsolated coronary artery ectasia (ICAE) is frequently encountered in clinical practice with increasing invasive imaging methods, and our knowledge about its etiology, prognosis, and treatment approaches is increasing daily.1,2 We read with great interest the recent retrospective study of Dindas et al.,3 which deals with the relationship between the Systemic Immune Inflammation Index (SII) and ICAE.3 It has been suggested that SII neutrophils, platelets, and lymphocytes collected in a single fraction may be a good indicator of inflammation and immune response.4 Various studies have shown that SII may have a more potent prognostic value than conventional inflammatory markers such as Neutrophil Lymphocyte Ratio (NLR) and Platelet Lymphocyte Ratio (PLR).5 We would like to comment on the well-designed and presented article, which we think will contribute significantly to the literature.Öğe Reply to letter to the editor: Pros and cons of a novel coronary stenting technique for medina 0.0.1 lesions: Osdokina crush(Kare Publication, 2023) Acar, Emrah; Güneş, Yılmaz; İzgi, İbrahim Akın; Kırma, CevatTo the Editor, We would like to express our gratitude to the authors for carefully reading and analyzing our case report.1 One of the most intriguing lesions in terms of percutaneous coronary interventions carried out in coronary bifurcation lesions is Medina 0.0.1 or isolated ostial side branch (SB) lesions.2 Percutaneous coronary interventions techniques for Medina 0.0.1 lesions are generally divided into 2 categories in the literature: those that involve stenting the ostial lesion and those that involve balloon angioplasty with atherectomy on the ostial lesion.Öğe The HbA1c/C-peptide ratio is associated with the no-reflow phenomenon in patients with ST-elevation myocardial infarction(Sage Publications Inc, 2023) Toprak, Kenan; Kaplangoray, Mustafa; Memioğlu, Tolga; İnanır, Mehmet; Omar, Bahadır; Ermiş, Mehmet FatihCurrently, the gold standard treatment for ST-elevation myocardial infarction (STEMI) is primary percutaneous coronary intervention (pPCI), but even after successful pPCI, a perfusion disorder in the epicardial coronary arteries, termed no-reflow phenomenon (NR), can develop, resulting in short- and long-term adverse events. The present study assessed the relationship between NR and HbA1c/C-peptide ratio (HCR) in 1834 consecutive patients who underwent pPCI due to STEMI. Participants were divided into two groups according to NR status and the demographic, clinical and periprocedural characteristics of the groups were compared. NR developed in 352 (19.1%) of the patients in the study. While C-peptide levels were significantly lower in the NR group, HbA1c and HCR were significantly higher (P < .001, for all). In multivariable analysis, C-peptide, HbA1c, and HCR, were determined as independent predictors for NR (P < .05, for all). In Receiver Operating Characteristic (ROC) analysis, HCR predicted the NR with 80% specificity and 77% sensitivity. In STEMI patients, combining HbA1c and C-peptide in a single fraction has a predictive value for NR independent of diabetes. This ratio may contribute to risk stratification of STEMI patients.Öğe Relationship of Thrombospondin-1 and Thrombospondin-2 with hematological, biochemical and inflammatory markers in COVID-19 patients(Walter De Gruyter GMBH, 2023) Doğan, Serdar; Okuyan, Hamza Malik; Bal, Tayibe; Çabalak, Mehmet; Begen, Mehmet AObjectives: Roles of Thrombospondin-1 (TSP-1) and Thrombospondin-2 (TSP-2) in tissue repair and inflammation are well-documented, but the association of their serum expressions with the pathogenesis of COVID-19 remains unclear. We investigate the roles of TSP-1 and TSP-2 in COVID-19. Methods: 106 SARS-CoV-2 infected patients and 23 healthy people were enrolled in our study. COVID-19 patients were divided into two groups as non-severe and severe. TSP-1 and TSP-2 concentrations were measured with an enzyme-linked Immunosorbent Assay, and blood markers were analyzed with routine laboratory techniques. Results: COVID-19 patients had significantly higher TSP-1 and TSP-2 levels than healthy controls. TSP-1 and TSP-2 positively correlated with inflammatory markers, including ESR, CRP, PCT, ferritin, and biochemical parameters such as ALT, AST, BUN, CK, and LDH. In addition, TSP-1 and TSP-2 were negatively correlated with hematological markers such as LYM, EOS, and HGB. Receiver operating characteristic analyses revealed that COVID-19 may be predicted with TSP-1 levels over 189.94 ng/mL and TSP-2 levels higher than 0.70 ng/mL. Conclusions: Our analysis suggests that TSP-1 and TSP-2 expressions at the systemic level may have clinical importance for COVID-19.Öğe Differential effects of disruptive mood dysregulation disorder comorbidity in attention deficit hyperactivity disorder on social cognition and empathy(Sage Publications Inc, 2024) Özyurt, Gonca; Öztürk, Yusuf; Tufan, Ali Evren; Akay, Aynur; İnal, NeslihanObjective: This study aimed to investigate social cognition and empathy properties in children among Disruptive Mood Dysregulation Disorder (DMDD) + Attention and Hyperactivity Disorder(ADHD); ADHD and healthy controls from Turkiye. Methods: Twenty-two children with DMDD were compared to matched 30 children with ADHD and 60 healthy controls. We administered Affective Reactivity Index (ARI), KaSi Empathy Scale, Kiddie-SADS, and Reading Mind in the Eyes Test (RMET) to evaluate Theory of Mind skills to all study participants. Results: DMDD + ADHD group had lower performance in ToM skills and empathy than in two groups. The ARI scores were found to be statistically significantly higher in the DMDD group than in two groups. It was also found that ARI, empathy, and ToM scores were significantly related in children with DMDD + ADHD. Conclusion: These results might be important to understand the difficulties in social functioning and interpersonal relationship in children with DMDD and ADHD. Children with DMDD may attend specific therapeutic programs which include specific techniques in social cognition, emotion regulation, and irritability.Öğe Single-stent double-kissing nano-crush technique for the management of side branch ostial lesions: A game changer? Or just another player in the game?(Kare Publishing, 2023) Acar, Emrah; Güneş, Yılmaz; İzgi, İbrahim Akın; Kırma, CevatTo the Editor, We would like to thank the authors1 for reading and thoroughly analyzing our case report.2 Isolated ostial side branch (SB) lesions, also known as Medina 0.0.1 lesions, are among the most fascinating lesions in terms of percutaneous coronary procedures performed in coronary bifurcation lesions.3 Stenting the ostial lesion and balloon angioplasty with atherectomy on the ostial lesion are the 2 main types of percutaneous coronary interventional procedures for Medina 0.0.1 lesions in the literature.4 The biggest argument against balloon-based treatment is that if ostial lesions with a high tendency to dissect and recoil are not covered by a “stentscaffold,” it may increase the risk of target lesion revascularization and target vessel revascularization.4 The “One Stent DOuble KIssing NAno CRUSH (OSDOKINA) technique,” which we have outlined, has a number of potential advantages. The ostial lesion is first to be entirely covered with a stent. Second, the major branch has a nano-protruding SB stent. Third, nano-protruded stent components are crushed in the main branch using an non-compliant balloon. There are 2 kissing balloon inflations to overcome the carina and plaque shift. Finally, a 1 : 1 sized drug-eluted balloon is inflated at the main branch for 90 seconds at 14 atm to prevent balloon-induced barotrauma from causing main branch restenosis.Öğe One-stent double-kissing nano crush- osdokina crush-technique could be a game-changer in the treatment of medina 0.0.1 lesion(Kare Publishing, 2023) Acar, Emrah; Güneş, Yılmaz; İzgi, İbrahim Akın; Kırma, CevatIn terms of percutaneous coronary interventions (PCI) performed in coronary bifurcation lesions, one of the most interesting lesions is Medina 0.0.1 lesions or isolated osteal side branch lesions.1-4 There are 5 important problems that should be answered with regard to PCI of Medina 0.0.1 lesion: (1) is osteal side branch stenosis serious enough to cause ischemia? (2) will possible complications develop in the main branch (such as dissection, plaque or carina shift-induced stenosis, and thrombus formation)? (3) if it is to be intervened, which technique? (4) how do we prepare the lesion? (5) if we are going to place a stent on the osteal lesion, will we be able to cover this lesion completely without overflowing into the main branch?Öğe Blood group as a novel predictor of postoperative atrial fibrillation after off-pump coronary artery bypass grafting(Associação Médica Brasileira, 2023) Dönmez, İbrahim; Müdüroğlu, AyhanOBJECTIVE: The objective of this study was to reveal whether there was a possible relationship between the blood group and postoperative atrial fibrillation after off-pump coronary artery bypass grafting.METHODS: Between January 2020 and January 2022, 452 patients undergoing off-pump coronary artery bypass grafting surgery consisted of the research population. Patients were divided into two groups based on the occurrence of new-onset atrial fibrillation from the time of operation until discharge. Group 1 (atrial fibrillation group) had 122 patients, whereas group 2 (non-atrial fibrillation group) contained 350 patients. Patients' baseline clinical characteristics and operative and postoperative data were recorded and then compared between the groups. Moreover, a multivariate logistic regression analysis was also conducted to identify the predictors of postoperative atrial fibrillation.RESULTS: Non-O blood groups were substantially more common in the atrial fibrillation group than in the non-atrial fibrillation group. Patient age differences between the atrial fibrillation and non-atrial fibrillation groups were statistically significant, and patients in the atrial fibrillation group were detected to be older. Mean left atrial diameter, rates of obesity and prior percutaneous coronary intervention history, and perioperative intraaortic balloon pump requirement were significantly greater in the atrial fibrillation group than in the non-atrial fibrillation group. According to logistic regression analysis, blood group, age, left atrial diameter, obesity, and prior percutaneous coronary intervention were identified as predictors of postoperative atrial fibrillation.CONCLUSION: We demonstrated for the first time in the literature that ABO blood type was a novel and significant predictor of new-onset atrial fibrillation after off-pump coronary artery bypass grafting.Öğe The association between sodium citrate cotransporter (NaDC-1) gene polymorphism and urinary citrate excretion in patients with calcium-containing kidney stones(Galenos Publ House, 2023) Çalışkan, Ahmet; Memik, Ömür; Düzenli, Selma; Tekin, AliObjective: To evaluate the relationship between sodium citrate cotransporter (NaDC-1) gene polymorphism and urinary citrate excretion in patients with kidney stones containing calcium. Materials and Methods: Between June 2009 and August 2011, stone materials obtained from patients treated for nephrolithiasis at the Urology Clinic were examined using X-ray diffraction, and patients with calcium-containing stones (calcium oxalate and calcium phosphate) were identified. Patients were divided into two groups based on their 24-hour urine citrate levels: (1) those with normal urine citrate levels and (2) hypocitraturia. To analyze the rs11567842 mutation in the NaDC-1 gene, their blood was collected in a Na-EDTA hemogram tube and stored at -40 degrees C. The genotypes of the cases were determined by analyzing the obtained genomic DNAs in real-time polymerase chain reaction. Results: Ninety-six patients with calcium-containing nephrolithiasis were eligible for this study, 40 with normal urine citrate levels and 56 with hypocitraturia. The mean 24-hour urine citrate levels in the normal- and hypo-citraturia groups were 773 mg/1.73 m(2)/24 hours and 152 mg/1.73 m(2)/24 hours, respectively. Citrate measurements revealed a statistically significant difference between the two groups (p<0.001). Twenty-fourhour urine oxalate, magnesium, calcium, and uric acid levels did not differ significantly between the groups (all p>0.05). NaDC-1 gene rs11567842 homozygous mutation (GG genotypes) was detected in 4 (10%) of normocitraturia and 4 (7%) of hypocitraturia. The normocitraturia group had a higher mutation rate than the hypocitraturia group, but this difference was insignificant (p=0.618). Conclusion: This study suggests that the NaDC-1 gene polymorphism does not cause hypocitraturia in calcium-containing kidney stones. Larger studies are needed to understand genetic disorders' impact on low urinary citrate excretion, with patient groups and healthy controls, and a standard diet.Öğe Was it really culture-negative infective endocarditis?(Elsevier, 2023) Gözdaş, Hasan Tahsin; Doğan, AhmetTo the Editor: We read the case report by Alabdaljabar et al1 with great interest. Their case was a 20-year-old previously healthy man who was diagnosed with multiple intramuscular abscesses and culture-negative infective endocarditis. Methicillin-resistant Staphylococcus aureus (MRSA) was isolated from his abscesses, whereas blood cultures yielded no growth.Öğe The role of platelet distribution width in the diagnosis of ischemic and hemorrhagic stroke(Bayrakol Medical Publisher, 2023) Demirel, Mustafa Enes; Özel, SinanAim: Current efforts to find diagnoses using simple and widely used indices of platelet activation have focused on the platelet activation caused by morphological changes, including both pseudopodia formation and spherical shape. The aim of this study was to evaluate the effect of PDW in differentiating ischemic and hemorrhagic stroke.Material and Methods: The study included a total of 333 patients, of which 269 had ischemic stroke and 64 had hemorrhagic stroke. Demographic data of the patients such as gender and age, National Institutes of Health Stroke Scale (NIHSS), Glasgow Coma Scale (GCS) and the modified Rankin score (mRs) were recorded. Complete blood count parameters were also recorded and compared between the patients with ischemic and hemorrhagic stroke.Results: The mean age of the patients was found to be 72.3 +/- 12.71 years in the ischemic stroke group and 69.27 +/- 14.39 years in the hemorrhagic group. The median neutrophil count was statistically significantly higher in the hemorrhagic stroke group (p=0.041). The median level of albumin was statistically significantly higher in the patients with hemorrhagic stroke (p=0.010). The median PDW value was determined to be statistically significantly higher at 14.9 (11.9-17.8) in the ischemic stroke group compared to 12.85 (11.33-17.03) in the hemorrhagic stroke group (p=0.009).Discussion: As the PDW level was statistically significantly lower in patients with hemorrhagic stroke than in patients with ischemic stroke, it may be of value in distinguishing these two forms of stroke. However, further comprehensive, multi-center studies are needed to better understand the role of PDW in ischemic and hemorrhagic stroke.Öğe Brucellar prosthetic aortic valve endocarditis(Elsevier Science Inc, 2023) Gözdaş, Hasan Tahsin; Şahin, Sultan Beste; Uçaroğlu, Erhan RenanTo the Editor: A 56-year-old man was admitted to the cardiology outpatient clinic with a chief complaint of progressive dyspnea. His past medical history was remarkable for diabetes mellitus, essential hypertension, coronary artery disease, and left hemiplegia due to a cerebrovascular event. He also underwent prosthetic aortic valve replacement 16 years ago.Öğe Examination of the relationship between the theory of mind, neurocognitive functions and thought-language features in the schizophrenia and bipolar affective disorder I groups(Türkiye Sinir ve Ruh Sağlığı Derneği, 2023) Yağcı, Zehra Günay; Boztaş, Mehmet HamidObjective: In this study, it was aimed to examine the relationship of ToM with face-emotion recognition, executive functions and thought disorders in the schizophrenia (SC) and bipolar affective disorder I (BAD I) groups.Method: 40 SC, 40 BAD I and 40 healthy control groups were included, matched for age, gender, and educational status. Dokuz Eylul Theory of Mind Scale (DEToMS)) and Reading Mind in Eyes (RMET) test, Benton face recognition test (BFRT), Ekman emotion recognition battery, Wisconsin Card Sorting Test (WCST), Stroop test, Thought and Language Index (TLI) were used. Positive and Negative Symptoms Rating Scale (PANNS) in the SZ group, Young Mania Rating Scale (YMRS) in the BAD I group were used.Results: The number of perseverative responses in WSCT was higher in the SC group than the BAD I group. Recognition of the fearful expression scores, DEToMS total and subscale scores except irony were higher and scores of TLI were lower in healthy controls more than patients group. Recognition of the fearful expression scores, DEToMS total and subscale scores except irony were higher and scores of TLI were lower in BAD I group more than SC group. There was no difference between SC and BAD I groups between BFRT, emotion recognition except fearful expression and RMET scores. The best predictors of DEToMS were executive functions and TLI total score in the SC group and was emotion recognition in the BAD I group. The best predictors of the RMET score were executive functions and emotion recognition for both groups.Conclusion: Our findings suggest that social cognition remains a biomarker in patients with SZ and BAD I.Öğe Increased whole blood viscosity is associated with primary idiopathic complete atrioventricular block and poor clinical outcomes in these patients(IOS Press, 2023) Toprak, Kenan; Kaplangoray, Mustafa; Palice, Ali; İnanır, Mehmet; Memioğlu, Tolga; Kök, ZaferBACKGROUND: Complete atrioventricular block is most commonly caused by age-related degeneration and fibrosis in the cardiac conduction system and is called primary idiopathic complete atrioventricular (iCAVB). Although many factors affect this situation, which increases with age in the cardiac conduction system, the relationship between whole blood viscosity (WBV) and iCAVB has not been clarified until now. In this study, we aim to reveal the relationship between iCAVB and WBV. METHODS AND RESULTS: 141 patients with dual-chamber permanent pacemaker implanted for iCAVB and 140 ageand sex-matched subjects were included in this study. The WBV values of the study groups were compared in both high shear rate (HSR) and low shear rate (LSR). Both WBV at HSR and WBV at LSR were significantly higher in the iCAVB group compared to the control group (16.11 [15.14-16.89] vs 14.40 [13.62-15.58]; 39.82 [17.43-55.23] vs 1.38 [-13.14-26.73]; p < 0.001, respectively). The patient population was followed up for an median of 38 months for all-cause mortality. Higher mortality rates were found in higher WBV at HSR and WBV at LSR (p < 0.001,for both). CONCLUSIONS: In this study, WBV was found to be an independent predictor for iCAVB, and in these patients WBV was associated with poor clinical outcomes.Öğe A chemically induced experimental colitis model with a simple combination of acetic acid and trinitrobenzene sulphonic acid(Aves, 2023) Cinpolat, Havva Yasemin; Buğdaycı, Güler; Şengül, Neriman; Astarcı, Hesna MüzeyyenBackground: It was aimed to induce a new experimental colitis model by using acetic acid and trinitrobenzene sulphonic acid together and to investigate the severity of inflammation biochemically and histopathologically in comparison with other models. Methods: Fifty-six Wistar albino male rats were randomly divided into 4 groups as control, acetic acid, trinitrobenzene sulphonic acid, and combined groups, and the animals were sacrificed following the induction of colitis on the third day and on the seventh day. The serum amyloid A and myeloperoxidase were tested in plasma samples, and the tumor necrosis factor-alpha, interleukin 33, and ST2 were assayed in colon tissue samples with enzyme-linked immunosorbent assay in addition to histopathological examination. Results: There were statistically significant differences between the combined and the control groups both on the third day and on the seventh day in all parameters. There was no difference between the acetic acid group on the seventh day and the control groups in biochemical parameters. Conclusions: The acetic acid model forms acute colitis. The combined model is found to be more successful in forming inflammation when compared to other models.Öğe Could serum uric acid to HDL cholesterol ratio predict sacroiliitis?(Public Library Science, 2023) Kalfaoğlu, Melike ElifRecently, several inflammatory markers, including the uric acid to HDL cholesterol ratio (UHR), triglyceride/HDL cholesterol ratio (THR), systemic inflammatory index (SII), and C-reactive protein to albumin ratio (CAR), have been reported to be associated with inflammatory conditions. However, their collective role in sacroiliitis has not been extensively studied. This study aims to investigate the general characteristics and inflammatory markers in patients with and without sacroiliitis, and to observe any differences in these parameters in subjects with active and chronic sacroiliitis. Patient with sacroiliitis who showed up in the Radiology Department of Abant Izzet Baysal University Hospital were enrolled. Patients diagnosed with sacroiliitis based on clinical symptoms, physical examination, and conventional radiography or MRI findings were included in the sacroiliitis group. Patients without sacroiliitis who present with back pain or hip pain but have normal radiographic findings were included in the control group. General characteristics, including age, sex, body mass index (BMI), medical history, and disease duration, were collected from all participants. Blood samples were collected to measure inflammatory markers, including UHR, THR, SII, and CAR. The collected data were compared between sacroiliitis and control groups. Subgroup analysis was also performed to compare the inflammatory markers between subjects with active and chronic sacroiliitis. The median UHR of the sacroiliitis and control subjects were 11% (3-20%) and 7% (3-13%), respectively (p<0.001). Serum UHR was significantly and positively correlated with CRP (r: 0.4, p = 0.001) and ferritin (r: 0.17, p = 0.045) levels. In ROC analysis, a UHR level higher than 8% has an 81% sensitivity and 64% specificity in detecting sacroiliitis (AUC: 0.8, p<0.001, 95% CI: 0.72-0.84). In conclusion, we suggest that UHR could provide useful data as an additional diagnostic tool in patients with sacroiliitis.
