Activation of TRESK background potassium channels by cloxyquin exerts protective effects against excitotoxic-induced brain injury and neuroinflammation in neonatal rats
Yükleniyor...
Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elseiver
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
We investigated effects of activation of TRESK channels by selective activator cloxyquin on excitotoxic-induced brain injury and neuroinflammation involving brain mast cells and inflammatory cytokines in neonatal rats. Three different doses of cloxyquin (0.2, 1 and 5 mg/kg) were studied in ibotenate-induced perinatal brain injury (PBI) in P5 rat-pups. Cerebral lesions and mast cells in coronal brain sections were evaluated. Concentrations of activin A, IL-1 beta, IL-6 and IL-10 in brain homogenates were measured using ELISA. Cloxyquin dose-dependently exerted protective effects against excitotoxic-induced neonatal brain injury and neuroinflammation. TRESK channels may be a promising new target for the treatment of PBIs.
Açıklama
This study was supported by Bolu Abant Izzet Baysal University Scientific Research Fund (Grant-number: 2019.08.23.1433).
19th Turkish Neuroscience Congress
19th Turkish Neuroscience Congress
Anahtar Kelimeler
Excitotoxicity, Brain mast cells, Neuroinflammation, Mast-Cells, Early Responders, Activin-A
Kaynak
Journal of Neuroimmunology
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
368
Sayı
Künye
Dilek, M., Kilinc, Y. B., Kilinc, E., Torun, I. E., Saylan, A., & Duzcu, S. E. (2022). Activation of TRESK background potassium channels by cloxyquin exerts protective effects against excitotoxic-induced brain injury and neuroinflammation in neonatal rats. Journal of Neuroimmunology, 368, 577894.
