Tear and serum vitamin D levels in children with allergic rhinoconjunctivitis

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dc.authorid0000-0003-2469-9509en_US
dc.authorid0000-0001-7778-1114
dc.authorid0000-0001-6745-4849
dc.contributor.authorGöksügür, Sevil Bilir
dc.contributor.authorErdurmuş, Mesut
dc.contributor.authorBekdaş, Mervan
dc.contributor.authorErkoçoğlu, Mustafa
dc.contributor.authorAğca, Sümeyra
dc.contributor.authorTosun, Mehmet
dc.contributor.authorGöksügür, Nadir
dc.date.accessioned2021-06-23T19:37:28Z
dc.date.available2021-06-23T19:37:28Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Although solid cohort studies confirmed a preventative role for the anti-oxidant vitamin D in allergic asthma, a limited number of studies focused on allergic rhinoconjunctivitis (ARC). Here, we aimed to determine 25-hydroxycholecalciferol levels in tear and serum in young allergic rhinoconjunctivitis patients as compared to their apparently healthy matched controls. Methods: In total, 22 children with allergic rhinoconjunctivitis and 31 healthy control subjects underwent serum total IgE and 25-hydroxycholecalciferol measurements. Tear levels of 25-hydroxycholecalciferol were also determined in both groups. Results: The mean serum total IgE level in the ARC group (143.6 +/- 132.8 IU/ml) was significantly higher than that in the control group (54.8 +/- 44.1 IU/ml; p=0.03). Serum 25(OH)D levels were significantly higher in the ARC group (34.1 +/- 12.7 ng/ml) than in the healthy controls (21.8 +/- 11.3 ng/ml; p=0.001). Conclusions: To our knowledge, this is the first reported study to show an association between serum 25-hydroxycholecalciferol and ARC in a childhood group. Higher levels of serum 25-hydroxycholecalciferol in children with allergic rhinoconjunctivitis may indicate a possible aetiopathogenic mechanism in the development of allergic rhinoconjunctivitis. This is also the first report to examine tear fluid vitamin D levels in paediatric ARC patients. (C) 2014 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.en_US
dc.identifier.doi10.1016/j.aller.2014.10.004
dc.identifier.endpage537en_US
dc.identifier.issn0301-0546
dc.identifier.issn1578-1267
dc.identifier.issue6en_US
dc.identifier.pmid25796302en_US
dc.identifier.scopus2-s2.0-84946501388en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage533en_US
dc.identifier.urihttps://doi.org/10.1016/j.aller.2014.10.004
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8163
dc.identifier.volume43en_US
dc.identifier.wosWOS:000365454200003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGöksügür, Sevil Bilir
dc.institutionauthorErdurmuş, Mesut
dc.institutionauthorBekdaş, Mervan
dc.institutionauthorErkoçoğlu, Mustafa
dc.institutionauthorAğca, Sümeyra
dc.institutionauthorTosun, Mehmet
dc.institutionauthorGöksügür, Nadir
dc.language.isoenen_US
dc.publisherElsevier Doyma Slen_US
dc.relation.ispartofAllergologia Et Immunopathologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAllergic Rhinoconjunctivitisen_US
dc.subjectImmunoglobulin Een_US
dc.subjectTearen_US
dc.subjectVitamin Den_US
dc.titleTear and serum vitamin D levels in children with allergic rhinoconjunctivitisen_US
dc.typeArticleen_US

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