Tear and serum vitamin D levels in children with allergic rhinoconjunctivitis
Yükleniyor...
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Doyma Sl
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Although solid cohort studies confirmed a preventative role for the anti-oxidant vitamin D in allergic asthma, a limited number of studies focused on allergic rhinoconjunctivitis (ARC). Here, we aimed to determine 25-hydroxycholecalciferol levels in tear and serum in young allergic rhinoconjunctivitis patients as compared to their apparently healthy matched controls. Methods: In total, 22 children with allergic rhinoconjunctivitis and 31 healthy control subjects underwent serum total IgE and 25-hydroxycholecalciferol measurements. Tear levels of 25-hydroxycholecalciferol were also determined in both groups. Results: The mean serum total IgE level in the ARC group (143.6 +/- 132.8 IU/ml) was significantly higher than that in the control group (54.8 +/- 44.1 IU/ml; p=0.03). Serum 25(OH)D levels were significantly higher in the ARC group (34.1 +/- 12.7 ng/ml) than in the healthy controls (21.8 +/- 11.3 ng/ml; p=0.001). Conclusions: To our knowledge, this is the first reported study to show an association between serum 25-hydroxycholecalciferol and ARC in a childhood group. Higher levels of serum 25-hydroxycholecalciferol in children with allergic rhinoconjunctivitis may indicate a possible aetiopathogenic mechanism in the development of allergic rhinoconjunctivitis. This is also the first report to examine tear fluid vitamin D levels in paediatric ARC patients. (C) 2014 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.
Açıklama
Anahtar Kelimeler
Allergic Rhinoconjunctivitis, Immunoglobulin E, Tear, Vitamin D
Kaynak
Allergologia Et Immunopathologia
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
43
Sayı
6
