Histopathological effects of intranasal phototherapy and nasal corticosteroids in allergic rhinitis in a rabbit model

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dc.authorid0000-0001-5387-2628
dc.authorid0000-0002-4552-0048
dc.authorid0000-0002-6838-7390
dc.contributor.authorYurttaş, Veysel
dc.contributor.authorŞereflican, Murat
dc.contributor.authorErkoçoğlu, Mustafa
dc.contributor.authorTerzi, Elçin Hakan
dc.contributor.authorKükner, Aysel
dc.contributor.authorOral, Mesut
dc.date.accessioned2021-06-23T19:41:58Z
dc.date.available2021-06-23T19:41:58Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractAllergic rhinitis is one of the most common health problems and has a major effect on quality of life. Although new-generation antihistamines and nasal steroids are the main treatment options, complete resolution cannot be obtained in some patients. Besides common side effects such as nasal irritation and epistaxis, the use of these drugs is controversial in some patients, such as pregnant or breastfeeding women. These findings highlight the need for new treatment options. Although phototherapy has been successfully used in the treatment of atopic dermatitis, which is an IgE-mediated disease and shares several common pathogenic features with allergic rhinitis, there are limited studies about its role in the treatment of allergic rhinitis. In this study, we aimed to evaluate and compare the histopathological effects of intranasal phototherapy (Rhinolight) and nasal corticosteroid treatment on the nasal mucosa in allergic rhinitis in a rabbit model and we found that both treatment options significantly reduced inflammation in the nasal mucosa without increasing apoptosis of mucosal cells. (C) 2015 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.jphotobiol.2015.06.011
dc.identifier.endpage291en_US
dc.identifier.issn1011-1344
dc.identifier.pmid26123190en_US
dc.identifier.scopus2-s2.0-84933041913en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage289en_US
dc.identifier.urihttps://doi.org/10.1016/j.jphotobiol.2015.06.011
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8268
dc.identifier.volume149en_US
dc.identifier.wosWOS:000358628400035en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYurttaş, Veysel
dc.institutionauthorŞereflican, Murat
dc.institutionauthorErkoçoğlu, Mustafa
dc.institutionauthorTerzi, Elçin Hakan
dc.institutionauthorKükner, Aysel
dc.institutionauthorOral, Mesut
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal Of Photochemistry And Photobiology B-Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAllergic Inflammationen_US
dc.subjectAllergic Rhinitisen_US
dc.subjectHistopathological Findingsen_US
dc.subjectIntranasal Phototherapyen_US
dc.subjectIntranasal Steroid Treatmenten_US
dc.subjectRhinolighten_US
dc.titleHistopathological effects of intranasal phototherapy and nasal corticosteroids in allergic rhinitis in a rabbit modelen_US
dc.typeArticleen_US

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