Histopathological effects of intranasal phototherapy and nasal corticosteroids in allergic rhinitis in a rabbit model
Yükleniyor...
Dosyalar
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Sa
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Allergic rhinitis is one of the most common health problems and has a major effect on quality of life. Although new-generation antihistamines and nasal steroids are the main treatment options, complete resolution cannot be obtained in some patients. Besides common side effects such as nasal irritation and epistaxis, the use of these drugs is controversial in some patients, such as pregnant or breastfeeding women. These findings highlight the need for new treatment options. Although phototherapy has been successfully used in the treatment of atopic dermatitis, which is an IgE-mediated disease and shares several common pathogenic features with allergic rhinitis, there are limited studies about its role in the treatment of allergic rhinitis. In this study, we aimed to evaluate and compare the histopathological effects of intranasal phototherapy (Rhinolight) and nasal corticosteroid treatment on the nasal mucosa in allergic rhinitis in a rabbit model and we found that both treatment options significantly reduced inflammation in the nasal mucosa without increasing apoptosis of mucosal cells. (C) 2015 Elsevier B.V. All rights reserved.
Açıklama
Anahtar Kelimeler
Allergic Inflammation, Allergic Rhinitis, Histopathological Findings, Intranasal Phototherapy, Intranasal Steroid Treatment, Rhinolight
Kaynak
Journal Of Photochemistry And Photobiology B-Biology
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
149
