Acinetobacter baumannii pneumonia increases surfactant proteins SP- A, SP-B, and SP-D levels, while decreasing SP-C level in bronchoalveolar lavage in rats

dc.authorid0000-0003-0442-5981en_US
dc.authorid0000-0002-9026-4485en_US
dc.authorid0000-0001-6768-1275en_US
dc.authorid0000-0002-6553-4500en_US
dc.contributor.authorÖzarslan, Talat Oğulcan
dc.contributor.authorSırmatel, Fatma
dc.contributor.authorKarabörk, Şeyda Özsoy
dc.contributor.authorDüzcü, Selma Erdoğan
dc.contributor.authorAstarcı, Hesna Müzeyyen
dc.date.accessioned2023-09-28T13:10:32Z
dc.date.available2023-09-28T13:10:32Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Lisansüstü Eğitim Enstitüsü, Sağlık Bilimleri, Enfeksiyon Hastalıkları Ana Bilim Dalıen_US
dc.descriptionThis study was supported by the Coordination Unit of Scienti fic Research Projects of Bolu Abant Izzet Baysal University, Bolu, Turkey (2018.08.26.1389) and the 100/2000 PhD Scholarship Program of the Council of Higher Education of Turkey.en_US
dc.description.abstractAcinetobacter baumannii is an opportunistic pathogen which causes nosocomial infections and high mortality. It is one of the most isolated microorganisms from patients with nosocomial pneumonia. Lung surfactant proteins (SP) are crucial for lung functions, and levels of SP-A, SP-B, SP-C, and SP-D change in the presence of infection. How they are affected in A. baumannii pneumonia, however, has not been conclusively researched. Therefore, the aim of the present study is to investigate the effect of A. baumannii pneumonia on surfactant proteins. 54 six-to-seven-month-old Sprague-Dawley rats were divided into two groups: sham and A. baumannii. The rats were administered 100 ml 0.5 McFarland A. baumannii or sterile saline intratracheally according to their group. Following the inoculation, lung and bronchoalveolar lavage fluids (BALF) were collected on the 3rd, 24th, and 48th hours of instillation. The lungs were examined histopathologically and the SP-A, SP-B, SP-C, and SP-D levels in BALF were measured with ELISA. The rats challenged with A. baumannii had significantly higher SP-A, SP-B, and SPD levels while having a significantly lower SP-C level compared to their sham equivalents. Furthermore, a strong positive correlation between SP-A and SP-D, and a moderate negative correlation between SP-B and SP-C were observed.en_US
dc.identifier.citationÖzarslan, T. O., Sırmatel, F., Karabörk, Ş. Ö., Düzcü, S. E., & Astarcı, H. M. (2023). Acinetobacter baumannii pneumonia increases surfactant proteins SP-A, SP-B, and SP-D levels, while decreasing SP-C level in bronchoalveolar lavage in rats. Microbes and Infection, 25(4), 105064.en_US
dc.identifier.doi10.1016/j.micinf.2022.105064
dc.identifier.issn1286-4579
dc.identifier.issn1769-714X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85151318442en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.micinf.2022.105064
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11763
dc.identifier.volume25en_US
dc.identifier.wosWOS:000976672700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÖzarslan, Talat Oğulcan
dc.institutionauthorSırmatel, Fatma
dc.institutionauthorKarabörk, Şeyda Özsoy
dc.institutionauthorDüzcü, Selma Erdoğan
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofMicrobes and Infectionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcinetobacter Baumanniien_US
dc.subjectPneumoniaen_US
dc.subjectLung Surfactanten_US
dc.subjectSurfactant Proteinsen_US
dc.subjectSP-Aen_US
dc.titleAcinetobacter baumannii pneumonia increases surfactant proteins SP- A, SP-B, and SP-D levels, while decreasing SP-C level in bronchoalveolar lavage in ratsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
talat-ogulcan-ozarslan.pdf
Boyut:
2.32 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama: