Protective effects of N-acetyl cysteine on undescended testis after orchiopexy: A rat-model study

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dc.authorid0000-0003-1698-8263en_US
dc.authorid0000-0002-4313-8478en_US
dc.authorid0000-0002-8212-7149en_US
dc.authorid0000-0001-5400-0012en_US
dc.authorid0000-0002-6839-2632en_US
dc.authorid0000-0001-7858-0672en_US
dc.contributor.authorKemahlı, Eray
dc.contributor.authorÜyetürk, Uğur
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorErimşah, Sevilay
dc.contributor.authorÜyetürk, Ümmügül
dc.contributor.authorGücük, Adnan
dc.date.accessioned2024-02-13T13:50:45Z
dc.date.available2024-02-13T13:50:45Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: To assess the effectiveness of utilising N-acetyl cysteine (NAC) to treat tissue damage brought on by undescended testis (UT) in rats after orchiopexy.Study Design: Experimental study.Place and Duration of the Study: Bolu Abant Izzet Baysal University, Bolu, Turkey, from January 2018 to June 2020.Methodology: The UT model was created by administering flutamide to pregnant rats. Four groups of animals were created as the control group (offsprings of pregnant rats without flutamide), group II (UT), group III (UT + orchiopexy), and group IV (UT + orchiopexy + NAC); each containing eight animals.Results: Group IV had a higher level of glutathione peroxidase than groups III and II (p=0.001 and p=0.002, respectively). Malondialde-hyde was reduced in group IV compared with groups III and II (both p<0.001). There were differences in mean apoptotic cell counts (ACC) among the groups (p<0.001). ACC in group IV was lower than in group III (p<0.001). Sperm counts were higher in group IV than in groups III and II, and in group III they were higher than group II (p<0.001 all) and similar between groups IV and control group (p=0.102).Conclusion: Orchiopexy reduced UT-related testicular damage, additionally using NAC following orchiopexy may further reduce testic-ular damage through its antioxidant effects.en_US
dc.identifier.citationKemahli, E., Uyeturk, U., Cetinkaya, A., Erimsah, S., Uyeturk, U., & Gucuk, A. (2023). Protective Effects of N-Acetyl Cysteine on Undescended Testis after Orchiopexy: A Rat-model Study. Journal of the College of Physicians and Surgeons--Pakistan: JCPSP, 33(3), 319-324.en_US
dc.identifier.doi10.29271/jcpsp.2023.03.319
dc.identifier.endpage324en_US
dc.identifier.issn1022-386X
dc.identifier.issn1681-7168
dc.identifier.issue3en_US
dc.identifier.pmid36945164en_US
dc.identifier.scopus2-s2.0-85151043625en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage319en_US
dc.identifier.urihttp://dx.doi.org/10.29271/jcpsp.2023.03.319
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12017
dc.identifier.volume33en_US
dc.identifier.wosWOS:000953835800015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKemahlı, Eray
dc.institutionauthorÜyetürk, Uğur
dc.institutionauthorÇetinkaya, Ayhan
dc.language.isoenen_US
dc.publisherColl Physicians & Surgeons Pakistanen_US
dc.relation.ispartofJCPSP-Journal of the College of Physicians and Surgeons Pakistanen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectUndescended Testisen_US
dc.subjectTestis Damageen_US
dc.subjectOrchiopexyen_US
dc.subjectN-acetyl Cysteineen_US
dc.subjectAntioxidanten_US
dc.subjectTesticular Developmenten_US
dc.titleProtective effects of N-acetyl cysteine on undescended testis after orchiopexy: A rat-model studyen_US
dc.typeArticleen_US

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