Protective effects of N-acetyl cysteine on undescended testis after orchiopexy: A rat-model study
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Dosyalar
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Coll Physicians & Surgeons Pakistan
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: To assess the effectiveness of utilising N-acetyl cysteine (NAC) to treat tissue damage brought on by undescended testis (UT) in rats after orchiopexy.Study Design: Experimental study.Place and Duration of the Study: Bolu Abant Izzet Baysal University, Bolu, Turkey, from January 2018 to June 2020.Methodology: The UT model was created by administering flutamide to pregnant rats. Four groups of animals were created as the control group (offsprings of pregnant rats without flutamide), group II (UT), group III (UT + orchiopexy), and group IV (UT + orchiopexy + NAC); each containing eight animals.Results: Group IV had a higher level of glutathione peroxidase than groups III and II (p=0.001 and p=0.002, respectively). Malondialde-hyde was reduced in group IV compared with groups III and II (both p<0.001). There were differences in mean apoptotic cell counts (ACC) among the groups (p<0.001). ACC in group IV was lower than in group III (p<0.001). Sperm counts were higher in group IV than in groups III and II, and in group III they were higher than group II (p<0.001 all) and similar between groups IV and control group (p=0.102).Conclusion: Orchiopexy reduced UT-related testicular damage, additionally using NAC following orchiopexy may further reduce testic-ular damage through its antioxidant effects.
Açıklama
Anahtar Kelimeler
Undescended Testis, Testis Damage, Orchiopexy, N-acetyl Cysteine, Antioxidant, Testicular Development
Kaynak
JCPSP-Journal of the College of Physicians and Surgeons Pakistan
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
33
Sayı
3
Künye
Kemahli, E., Uyeturk, U., Cetinkaya, A., Erimsah, S., Uyeturk, U., & Gucuk, A. (2023). Protective Effects of N-Acetyl Cysteine on Undescended Testis after Orchiopexy: A Rat-model Study. Journal of the College of Physicians and Surgeons--Pakistan: JCPSP, 33(3), 319-324.
