Serum omentin level in patients with prostate cancer

Basit Öğe Kaydı
dc.authorid0000-0003-1698-8263
dc.authorid0000-0001-7858-0672
dc.authorid0000-0002-6839-2632
dc.authorid0000-0002-4313-8478
dc.authorid0000-0002-5924-7476
dc.contributor.authorÜyetürk, Uğur
dc.contributor.authorSarıcı, Haşmet
dc.contributor.authorTekçe, Buket Kın
dc.contributor.authorEroğlu, Muzaffer
dc.contributor.authorKemahlı, Eray
dc.contributor.authorÜyetürk, Ümmügül
dc.contributor.authorGücük, Adnan
dc.date.accessioned2021-06-23T19:36:07Z
dc.date.available2021-06-23T19:36:07Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractProstate cancer (PCa) is the second leading cause of cancer-related death in males. Hypertriglyceridemia and obesity are known risk factors for disease development. Omentin is a plasma adipokine that is synthesized in visceral adipose tissue; its plasma concentration changes in colorectal cancer and conditions associated with insulin resistance. To our knowledge, the relationship between omentin and PCa has not been investigated previously. Therefore, we evaluated omentin levels in PCa patients in this matched case-control study. Fifty consecutive patients newly diagnosed with PCa and 30 consecutive patients newly diagnosed with benign prostatic hyperplasia (BPH) were assessed. Patients with PCa were divided into three subgroups according to the Gleason score. The omentin concentrations were determined using enzyme-linked immunosorbent assays. Blood urea nitrogen (p < 0.001), creatinine (Cr; p < 0.001), total cholesterol (p < 0.001), low-density lipoprotein (p < 0.001), and prostate-specific antigen (PSA; p = 0.03) levels were significantly higher in the PCa group than the BPH group. The median omentin level in BPH patients was 373 (207-792) versus 546.8 (297.1-945.7) ng/mL in the PCa group (p < 0.001). There was a negative weak/moderate correlation between omentin and body mass index in the BPH group (r = -0.364, p = 0.048). Circulating omentin levels were elevated in patients with PCa. Further studies would be useful to establish the mechanism underlying this increase and to assess the interaction between PCa and adipose tissue.en_US
dc.identifier.doi10.1007/s12032-014-0923-6
dc.identifier.issn1357-0560
dc.identifier.issn1559-131X
dc.identifier.issue4en_US
dc.identifier.pmid24659266en_US
dc.identifier.scopus2-s2.0-84896413883en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s12032-014-0923-6
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7935
dc.identifier.volume31en_US
dc.identifier.wosWOS:000334185200002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÜyetürk, Uğur
dc.institutionauthorTekçe, Buket Kın
dc.institutionauthorKemahlı, Eray
dc.institutionauthorÜyetürk, Ümmügül
dc.institutionauthorGücük, Adnan
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofMedical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProstate Canceren_US
dc.subjectOmentinen_US
dc.subjectAdipokineen_US
dc.titleSerum omentin level in patients with prostate canceren_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
ugur-uyeturk-7935.pdf
Boyut:
243.02 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam metin/Full text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Cerrahi Tıp Bilimleri Bölümü Koleksiyonu
Dahili Tıp Bilimleri Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Temel Tıp Bilimleri Bölümü Koleksiyonu