Can hyperoxic stress cause susceptibility to acute seizure in the neonatal period?: A rat study

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dc.authorid0000-0002-3802-0336en_US
dc.authorid0000-0002-0000-3768en_US
dc.authorid0000-0002-1019-9207en_US
dc.authorid0000-0002-6793-6888en_US
dc.authorid0000-0002-8073-3110en_US
dc.authorid0000-0002-5413-4157en_US
dc.contributor.authorDilek, Mustafa
dc.contributor.authorSoytürk, Hayriye
dc.contributor.authorBozat, Bihter Gökçe
dc.contributor.authorHancı, Fatma
dc.contributor.authorTaş, Sinan
dc.contributor.authorKabakuş, Nimet
dc.date.accessioned2023-12-25T10:53:26Z
dc.date.available2023-12-25T10:53:26Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionThe study was supported by Bolu Abant Izzet Baysal University Scientific Research Fund [Grant number: 2018.08.23.1404].en_US
dc.description.abstractObjective: Preterm neonates encounter hyperoxia relatively early, and are more exposed to hyperoxic stress due to their insufficient antioxidant defense mechanisms. This study was planned around the hypothesis that this hyperoxic effect may cause a disposition to future acute seizures. Methods: This study was composed of two main groups Hyperoxy and Control (Room air with normal O-2 levels) Groups. Group 1 - hyperoxia (Study): The experimental group consisted of premature newborn rats exposed to hyperoxia with their dams from birth to postnatal day 5. Group 2 - room air (Control): The group was not exposed to hyperoxia and housed the same room air and temperature as their dams. Female, Acute Epilepsy Female, Male, Acute Epilepsy Male, and a total of eight subgroups were formed in both the control and hyperoxia groups. When the rats were two months old, intracranial electrodes were attached to obtain electrocorticography (ECoG) recordings. Pre-model recordings were taken, after which an acute pentylenetetrazole (PTZ) model of absence seizure was induced by the intraperitoneal administration of PTZ at 50 mg/kg. ECoG records were examined using the PowerLab system for 180 min. Spike wave number and duration, Spike wave frequency and amplitude data were evaluated.Results: Seven female and three male rats were exposed to hyperoxia, and a control group of five female and three male rats were included in the study. The median interquartile range for spike wave latency in the hyperoxia and control groups were 1112 (644-1545) and 654 (408-1152), frequency 4476 (3120-7421) and 3934 (2264-4704), and amplitude data 0.68 (0.59-0.79) and 0.52 (0.37-0.67), respectively. Although a difference was observed in median values capable of constituting susceptibility to epilepsy, the difference was not statistically significant (p > 0.05). In terms of gender, spike-wave counts were significantly higher in female rats (p < 0.05). Females exposed to hyperoxia were more susceptible to epilepsy than both males and females in the control group (p < 0.05).Conclusion: Exposure to hyperoxia in the first days of life of premature neonates due to their susceptibility to oxidative stress and insufficient antioxidant mechanisms, can cause a disposition to acute seizures. As a result, females exposed to hyperoxia during the neonatal period may be prone to epilepsy in maturity.en_US
dc.description.sponsorshipBolu Abant Izzet Baysal University Scientific Research Fund [2018.08.23.1404]en_US
dc.identifier.citationDilek, M., Soytürk, H., Bozat, G., Hancı, F., Taş, S., & Kabakuş, N. (2022). Can hyperoxic stress cause susceptibility to acute seizure in the neonatal period?: a rat study. International Journal of Neuroscience, 1-7.en_US
dc.identifier.doi10.1080/00207454.2022.2140427
dc.identifier.endpage8en_US
dc.identifier.issn0020-7454
dc.identifier.issn1563-5279
dc.identifier.pmid36282040en_US
dc.identifier.scopus2-s2.0-85141136446en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.1080/00207454.2022.2140427
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11919
dc.identifier.wosWOS:000876163800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDilek, Mustafa
dc.institutionauthorSoytürk, Hayriye
dc.institutionauthorBozat, Bihter Gökçe
dc.institutionauthorHancı, Fatma
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal of Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPrematurityen_US
dc.subjectHyperoxiaen_US
dc.subjectAcute Seizureen_US
dc.subjectCell-Deathen_US
dc.subjectOxygenen_US
dc.subjectEpilepsyen_US
dc.titleCan hyperoxic stress cause susceptibility to acute seizure in the neonatal period?: A rat studyen_US
dc.typeArticleen_US

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