Protective and therapeutic effects of okra seed in acute nontraumatic brain injury

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dc.authorid0000-0003-0288-1529en_US
dc.authorid0000-0003-2469-9509en_US
dc.authorid0000-0003-0962-2116en_US
dc.authorid0000-0002-8212-7149en_US
dc.authorid0000-0001-6768-1275en_US
dc.authorid0000-0003-0434-3206en_US
dc.authorid0000-0001-9454-7944en_US
dc.authorid0000-0001-9865-1685en_US
dc.contributor.authorYoldaş, Meyri Arzu
dc.contributor.authorBekdaş, Mervan
dc.contributor.authorDanış, Ayşegül
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorDüzcü, Selma Erdoğan
dc.contributor.authorAlışık, Murat
dc.contributor.authorKocabey, Hüseyin
dc.contributor.authorTürel, İdris
dc.date.accessioned2024-05-29T06:37:41Z
dc.date.available2024-05-29T06:37:41Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAimThe purpose of this study was to examine the protective and therapeutic effects of okra (Abelmoschus esculentus [AE]) seed extract, with its known antioxidant, immunomodulatory, and anti-inflammatory properties, in an acetaminophen (paracetamol, N-acetyl- para-aminophenol)-induced model of hepatotoxicity and subsequent acute non-traumatic brain damage.Material and MethodForty male Wistar rats were randomly divided into five equal groups, control, paracetamol (P), okra seed extract (AE), okra seed extract + paracetamol (P + AE), and okra seed extract + paracetamol + N-acetyl cysteine (NAC) (P + AE + N). AE was administered by oral gavage through a gastric tube at 600 mg/kg/day for seven days. On the eighth day of the procedure, a single 1 g/kg dose of paracetamol and 300 mg/kg NAC were injected via the intraperitoneal route 1.5 h after AE administration. Rat tissue specimens were subsequently subjected to biochemical and histopathological analyses. Levels of markers such as S100 calcium-binding protein B (S100B), neuron-specific enolase (NSE), and matrix membrane metalloproteinase-9 (MMP-9) were investigated from rat serum specimens. Malondialdehyde (MDA) and superoxide dismutase (SOD) were also measured to determine oxidant-antioxidant status.ResultsS100B, NSE, MMP-9, MDA levels, and SOD enzyme activities were examined using biochemical methods. MDA levels were significantly lower in the P + AE group and MMP-9 levels in the AE, P + AE, and P + AE + N groups compared to the P group. Histopathological examination results supported the biochemical findingsConclusionOkra seed extract exhibits a protective and therapeutic effect against non-traumatic brain damage resulting from acute paracetamol intoxication. We think that this benefit of AE derives from its antioxidant property.en_US
dc.identifier.citationYoldaş, M. A., Bekdaş, M., Danış, A., Çetinkaya, A., Düzcü, S. E., Alışık, M., ... & Dinçel, G. K. (2023). Protective and therapeutic effects of okra seed in acute nontraumatic brain injury. International Journal of Neuroscience, 1-10.en_US
dc.identifier.doi10.1080/00207454.2023.2292948
dc.identifier.endpage11en_US
dc.identifier.issn0020-7454
dc.identifier.issn1563-5279
dc.identifier.pmid38060590en_US
dc.identifier.scopus2-s2.0-85179713705en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.1080/00207454.2023.2292948
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12180
dc.identifier.wosWOS:001123448600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYoldaş, Meyri Arzu
dc.institutionauthorBekdaş, Mervan
dc.institutionauthorÇetinkaya, Ayhan
dc.institutionauthorDüzcü, Selma Erdoğan
dc.institutionauthorAlışık, Murat
dc.institutionauthorKocabey, Hüseyin
dc.institutionauthorTürel, İdris
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal of Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAbelmoschus Esculentusen_US
dc.subjectAcute Non-Traumatic Brain Damageen_US
dc.subjectParacetamolen_US
dc.subjectNeuron-Specific Enolaseen_US
dc.subjectOxidative Stress; L.en_US
dc.subjectAcetaminophenen_US
dc.titleProtective and therapeutic effects of okra seed in acute nontraumatic brain injuryen_US
dc.typeArticleen_US

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