Effects of estrogen and progesterone on the neurogenic inflammatory neuropeptides: Implications for gender differences in migraine

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dc.authorid0000-0001-9261-2634en_US
dc.authorid0000-0002-8212-7149
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorKılınç, Erkan
dc.contributor.authorÇamsarı, Çağrı
dc.contributor.authorÖgün, Muhammed Nur
dc.date.accessioned2021-06-23T19:53:55Z
dc.date.available2021-06-23T19:53:55Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractNeurogenic inflammation including calcitonin gene-related peptide (CGRP) and substance-P (SP) release plays a pivotal role in migraine pathogenesis. Prevalence of migraine is similar to 3 folds higher in women than in men, but its underlying mechanisms remained unclear. We investigated the effects of female sex hormones estrogen and progesterone on CGRP and SP in in-vivo and ex-vivo in rats of both sexes. For in-vivo experiments, male, female and ovariectomized rats were separated into four groups (n = 7) as control, estrogen, progesterone and estrogen + progesterone, respectively. Groups received daily intraperitoneal vehicle, 17 beta-estradiol, progesterone and 17 beta-estradiol + progesterone for 5 days, respectively. For ex-vivo experiments in both sexes, isolated trigeminal ganglia and hemiskull preparations were divided into four groups (n = 6 or 8), respectively, as in-vivo groups, and administered the same test substances. CGRP and SP contents in plasma and superfusates were determined using ELISA. In in-vivo experiments, 17 beta-estradiol decreased CGRP levels in males and SP levels in ovariectomized rats. Progesterone increased both CGRP and SP levels in females. Their combination decreased both CGRP and SP levels in males, and only SP levels in ovariectomized rats. In ex-vivo experiments, 17 beta-estradiol reduced CGRP release in males and SP release in females in trigeminal ganglia. While progesterone increased CGRP release in trigeminal ganglia, it reduced SP release from hemiskulls in both sexes. Their combination restored progesterone-mediated changes in neuropeptides releases in both trigeminal ganglia and hemiskulls in both sexes. Estrogen alleviates neurogenic inflammation through modulation of CGRP and SP release. Progesterone has dual effects on these neuropeptides in different sites associated with migraine pain.en_US
dc.identifier.doi10.1007/s00221-020-05923-7
dc.identifier.endpage2639en_US
dc.identifier.issn0014-4819
dc.identifier.issn1432-1106
dc.identifier.issue11en_US
dc.identifier.pmid32924075en_US
dc.identifier.scopus2-s2.0-85090969222en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2625en_US
dc.identifier.urihttps://doi.org/10.1007/s00221-020-05923-7
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10336
dc.identifier.volume238en_US
dc.identifier.wosWOS:000568976700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇetinkaya, Ayhan
dc.institutionauthorKılınç, Erkan
dc.institutionauthorÇamsarı, Çağrı
dc.institutionauthorÖgün, Muhammed Nur
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofExperimental Brain Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGender Differenceen_US
dc.subjectMigraineen_US
dc.subjectNeurogenic Inflammationen_US
dc.subjectTrigeminovascular Systemen_US
dc.subjectCalcitonin Gene-related Peptideen_US
dc.subjectSubstance-Pen_US
dc.titleEffects of estrogen and progesterone on the neurogenic inflammatory neuropeptides: Implications for gender differences in migraineen_US
dc.typeArticleen_US

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