4-(3,4-dihydroxybenzoyloxymethyl)phenyl-O-beta-D-glucopyranoside effect in liver regeneration

dc.authorid0000-0002-8317-7092
dc.authorid0000-0002-7475-7298
dc.authorid0000-0003-0783-7180
dc.contributor.authorFırat, Tülin
dc.contributor.authorSöyler, Gizem
dc.contributor.authorTöre, Fatma
dc.contributor.authorŞit, Mustafa
dc.contributor.authorKıyan, Aysu
dc.contributor.authorÖzgen, Ufuk
dc.contributor.authorKükner, Aysel
dc.contributor.authorŞit, Mustafa
dc.date.accessioned2021-06-23T19:52:00Z
dc.date.available2021-06-23T19:52:00Z
dc.date.issued2019
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractFollowing an injury or resection, the mammalian liver has the capacity to regain its former volume and functioning by restoring itself. Studies have demonstrated that antioxidants play a role in hepatic regeneration. This study investigated the effect of 4-(3,4-dihydroxybenzoyloxymethyl)phenyl-O-beta-D-glucopyranoside (PG) obtained from Origanum micranthum on liver regeneration. Sixty Wistar Albino rats were used. In the sham-operated group, a midline abdominal laparotomy was performed without hepatectomy. In the partial hepatectomy (PHx) group, the median and left lateral lobes were removed. Rats in the PHx group received 20 mg/kg/day PG intraperitoneally before being sacrificed at 24, 48, and 72 hrs, and 7 days later. Liver tissues were collected for immunohistochemical analysis and electron microscopic evaluation. We found an increase in mitotic index, and the numbers of Ki-67 stained hepatocytes in all PHx early stage groups (24 hr, 48hr, 72 hr), but not in 7-day groups. The regeneration mediators eNOS, iNOS, TNF-alpha and NF-kappa B were shown to increase in PHx groups. This increase was more prominent dependening on time. In the PHx treatment (PHx+PG) groups, while eNOS was still high, iNOS, TNF-alpha and NF-kappa B had decreased. The apoptotic index was markedly high in the PHx groups; this was prevented by PG treatment. These findings were supported by the ultrastructural results. Our findings indicate that PG supports liver regeneration, hepatocyte proliferation, reduced liver damage, and inflammatory mediators following PHx.en_US
dc.identifier.doi10.14670/HH-18-056
dc.identifier.endpage443en_US
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.issue4en_US
dc.identifier.pmid30394506en_US
dc.identifier.scopus2-s2.0-85063959114en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage431en_US
dc.identifier.urihttps://doi.org/10.14670/HH-18-056
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10082
dc.identifier.volume34en_US
dc.identifier.wosWOS:000459539500011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorFırat, Tülin
dc.institutionauthorKıyan, Aysu
dc.institutionauthorŞit, Mustafa
dc.language.isoenen_US
dc.publisherF Hernandezen_US
dc.relation.ispartofHistology And Histopathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPartial Hepatectomyen_US
dc.subjectLiver Regenerationen_US
dc.subjectOriganum Micranthumen_US
dc.title4-(3,4-dihydroxybenzoyloxymethyl)phenyl-O-beta-D-glucopyranoside effect in liver regenerationen_US
dc.typeArticleen_US

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