Effect of inhaled budesonide on oropharyngeal, Gram-negative bacilli colonization in asthma patients

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dc.authorid0000-0003-1514-1685en_US
dc.authorid0000-0002-2860-1794
dc.contributor.authorTalay, Fahrettin
dc.contributor.authorKarabay, Oğuz
dc.contributor.authorYılmaz, Fahrettin
dc.contributor.authorKoçoğlu, Esra
dc.date.accessioned2021-06-23T19:20:49Z
dc.date.available2021-06-23T19:20:49Z
dc.date.issued2007
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractBackground and Objective: The effect of inhaled budesonide on oropharyngeal Gram-negative bacilli colonization (OGNBC) in asthmatic patients was investigated. Methods: Oropharyngeal cultures were obtained from asthmatic patients attending the hospital respiratory outpatient clinic, at baseline and 1 month after treatment with 800 mu g/day of inhaled budesonide. Cultures were evaluated for OGNBC and compared with those of healthy controls. Results: A total of 148 cultures (74 from asthma patients, 74 from healthy controls) were evaluated. Six cultures (8.1%) from healthy controls, eight cultures (10.8%) from asthma patients obtained before treatment and 20 cultures (27.0%) obtained after treatment were positive for OGNBC (P < 0.05). Gender, age, presence of atopy and the degree of illness were not found to be related to the presence of OGNBC in and healthy control cultures. In the cultures obtained from the patients after treatment, OGNBC was higher in patients > 50 years and in those with FEV1 < 70% (P < 0.05). Nine (18.8%) of 48 patients < 50 years compare with 11 (42.3%) of the 26 patients > 50 revealed OGNBC (P < 0.05). OGNBC were observed in 18.9% of the patients with FEV1 = 70% and in 47.6% of those with FEV1 < 70% (P < 0.05). Conclusions: The increased rate of OGNBC in asthma patients treated with inhaled budesonide was found to be related to increased age and lower level of FEV1. Further studies with larger numbers of patients are required for the interpretation of this colonization in the course of lower respiratory infections in these patients.en_US
dc.identifier.doi10.1111/j.1440-1843.2006.00976.x
dc.identifier.endpage80en_US
dc.identifier.issn1440-1843
dc.identifier.issue1en_US
dc.identifier.pmid17207029en_US
dc.identifier.scopus2-s2.0-33845691458en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage76en_US
dc.identifier.urihttps://doi.org/10.1111/j.1440-1843.2006.00976.x
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6174
dc.identifier.volume12en_US
dc.identifier.wosWOS:000242907000013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTalay, Fahrettin
dc.institutionauthorKarabay, Oğuz
dc.institutionauthorYılmaz, Fahrettin
dc.institutionauthorKoçoğlu, Esra
dc.language.isoenen_US
dc.publisherAsian Pacific Society of Respirologyen_US
dc.relation.ispartofRespirologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAsthmaen_US
dc.subjectInhaled Steroiden_US
dc.subjectOropharyngeal Gram-negative Colonizationen_US
dc.titleEffect of inhaled budesonide on oropharyngeal, Gram-negative bacilli colonization in asthma patientsen_US
dc.typeArticleen_US

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