Effects of pinealectomy and melatonin supplementation on endometrial explants in a rat model

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dc.authorid0000-0002-4060-3354en_US
dc.authorid0000-0002-8929-6973
dc.authorid0000-0001-7965-6229
dc.contributor.authorKoç, Önder
dc.contributor.authorGündüz, Bülent
dc.contributor.authorTopçuoğlu, Ata
dc.contributor.authorBuğdaycı, Güler
dc.contributor.authorYılmaz, Fahri
dc.contributor.authorDuran, Bülent
dc.date.accessioned2021-06-23T19:26:45Z
dc.date.available2021-06-23T19:26:45Z
dc.date.issued2010
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective To determine the effects of pinealectomy on endometrial explants in rats and evaluate the activity of superoxide dismutase (SOD) and catalase (CAT) and the levels of malondialdehyde (MDA) in the rat endometriosis model Study design Rats with experimentally induced endometriosis were randomly divided into three groups after second-look laparotomies Group 1 (pinealectomy n = 8) and Group 2 (pinealectomy + melatonin n = 8) underwent pinealectomies after the second-look laparotomies Group 3 was presented as control group (vehicle solution + without pinealectomy (n = 6)) Melatonin was administered intraperitoneally for 4 weeks in Group 2 whereas an equal volume of vehicle solution was given to Groups 1 and 3 Evaluation of the volume of the endometrial explants histopathological examination and preservation of explant epitheliums according to the scoring system were undertaken Results There was a statistically significant increase in spherical explant volumes of Group 1 compared to Groups 2 and 3 In Group 1 the level of MDA was significantly higher and SOD and CAT activity was significantly lower compared to Groups 2 and 3 A statistically significant increase in the epithelial lining scores of explants was noted in Group 1 compared to Groups 2 and 3 Conclusion The effects of pinealectomy on the progression of endometriosis explants were reversed by melatonin (C) 2010 Elsevier Ireland Ltd All rights reserveden_US
dc.identifier.doi10.1016/j.ejogrb.2010.06.012
dc.identifier.endpage76en_US
dc.identifier.issn0301-2115
dc.identifier.issn1872-7654
dc.identifier.issue1en_US
dc.identifier.pmid20667645en_US
dc.identifier.scopus2-s2.0-77958181796en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage72en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejogrb.2010.06.012
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6643
dc.identifier.volume153en_US
dc.identifier.wosWOS:000284298000015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKoç, Önder
dc.institutionauthorGündüz, Bülent
dc.institutionauthorTopçuoğlu, Ata
dc.institutionauthorBuğdaycı, Güler
dc.institutionauthorYılmaz, Fahri
dc.institutionauthorDuran, Bülent
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofEuropean Journal Of Obstetrics & Gynecology And Reproductive Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPinealectomyen_US
dc.subjectEndometriosisen_US
dc.subjectMelatoninen_US
dc.subjectAntioxidanten_US
dc.subjectRaten_US
dc.titleEffects of pinealectomy and melatonin supplementation on endometrial explants in a rat modelen_US
dc.typeArticleen_US

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