Effects of tibolone on blood flow resistance and intima-media thickness of the carotid arteries: effect of time since menopause
Yükleniyor...
Dosyalar
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective The aim of this prospective study was to evaluate the effects of tibolone on carotid atherosclerosis in healthy postmenopausal women. Methods Twenty-five healthy postmenopausal women were included in the study. Patients received tibolone 2.5 mg daily for 6 months. Resistance indices of the common carotid artery (CCA), internal carotid artery (ICA), external carotid artery (ECA) and vertebral arteries, and intima-media thickness of the CCA were measured both at baseline and at the end of the study with ultrasonography. Results No significant differences were observed in the resistance indices of the CCA, ICA, ECA and vertebral arteries, as well as intima-media thickness of CCA at 6 months in comparison with baseline. Tibolone significantly improved the intima-media thickness of the CCA of women who were less than 18 months since menopause. Conclusion Overall, these results demonstrate no significant effects of tibolone on either intima-media thickness or blood flow resistance in the carotid arteries in postmenopausal women. However, the results suggest that tibolone may have a positive effect on the vascular system if commenced within 18 months since menopause; this warrants further investigation.
Açıklama
21st Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology -- JUN 19-22, 2005 -- Copenhagen, DENMARK
Anahtar Kelimeler
Carotid Arteries, Intima-media Thickness, Menopause, Tibolone
Kaynak
Climacteric
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
9
Sayı
1
