Epicardial fat thickness in patients with rheumatoid arthritis

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dc.authorid0000-0001-8590-4831
dc.authorid0000-0002-6913-9073
dc.contributor.authorErdem, Fatma
dc.contributor.authorKoç, Bünyamin
dc.contributor.authorSarıkaya, Savaş
dc.contributor.authorUçar, Mehmet
dc.contributor.authorYazıcı, Selma
dc.contributor.authorBoyraz, İsmail
dc.contributor.authorÇağlar, Sabri
dc.contributor.authorÖzyalvaçlı, Gülzade
dc.contributor.authorDönmez, İbrahim
dc.contributor.authorYazıcı, Mehmet
dc.date.accessioned2021-06-23T19:42:31Z
dc.date.available2021-06-23T19:42:31Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Epidemiologic data indicates that rheumatoid arthritis is an independent risk factor for cardiovascular disease. Epicardial adipose tissue is a novel cardio-metabolic risk factor. Our aim was to evaluate epicardial fat thickness (EFT) using echocardiography in patients with rheumatoid arthritis compared to healthy control subjects. Secondly, we investigated relationship between epicardial fat thickness and clinical and echocardiographic parameters in patients with rheumatoid arthritis. Method: The study population included 76 consecutive patients with rheumatoid arthritis (64 female; mean age, 53 +/- 11 years, median disease duration, 7.8 years) and 50 healthy subjects as controls (39 female; mean age, 52 +/- 6 years). All patients underwent echocardiography to assess left ventricular diastolic dysfunction, left ventricular hypertrophy and EFT. All values were compared between groups. Results: EFT was higher in rheumatoid arthritis patients than in healthy controls (0.66 +/- 0.20 vs. 0.54 +/- 0.18; p=0.003). Thickness of Intra Ventricular Septum (IVS) (1.1 +/- 0.06 and 9.8 +/- 0.08; p=0.001) and posterior wall (PW) (0.98 +/- 0.05 and 0.93 +/- 0.08; p=0.015) was higher in patients with rheumatoid arthritis compared to healthy controls. Early diastolic myocardiac peak velocity or late diastolic mitral peak velocity (E/A) ratio was lower in rheumatoid arthritis patients compared to healthy patients (1.1 +/- 0.8 and 1.24 +/- 0.1 p=0.001) as well as, E/e' was higher in Rheumatoid arthritis (RA) patients than healthy patients. (E/e': 8.7 +/- 1.6 and 8.0 +/- 1.4 p=0.020). In patients with rheumatoid arthritis, EFT was positively correlated with hypertension and duration of disease and E/e' (r: 0.10, p: 0.010, r: 0.306, p: 0.004 and r: 0.465 p: 0.007 respectively) and EFT was negatively correlated with E/A (r: -. 262 p: 0.022) Conclusion: To our knowledge, this is the first report about epicardial adipose tissue in rheumatoid arthritis patients. Epicardial fat thickness as an indicator of cardiovascular involvement was higher in rheumatoid arthritis patients.en_US
dc.identifier.doi10.4314/ahs.v15i2.23
dc.identifier.endpage494en_US
dc.identifier.issn1680-6905
dc.identifier.issn1729-0503
dc.identifier.issue2en_US
dc.identifier.pmid26124795en_US
dc.identifier.scopus2-s2.0-84930066688en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage489en_US
dc.identifier.urihttps://doi.org/10.4314/ahs.v15i2.23
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8521
dc.identifier.volume15en_US
dc.identifier.wosWOS:000355535900023en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKoç, Bünyamin
dc.institutionauthorSarıkaya, Savaş
dc.institutionauthorBoyraz, İsmail
dc.institutionauthorÇağlar, Sabri
dc.institutionauthorÖzyalvaçlı, Gülzade
dc.institutionauthorDönmez, İbrahim
dc.institutionauthorYazıcı, Mehmet
dc.language.isoenen_US
dc.publisherMakerere Univ, Fac Meden_US
dc.relation.ispartofAfrican Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRheumatoid Arthritisen_US
dc.subjectEpicardial Fat Thicknessen_US
dc.subjectCardiac Involvementen_US
dc.titleEpicardial fat thickness in patients with rheumatoid arthritisen_US
dc.typeArticleen_US

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