Epicardial fat thickness in patients with rheumatoid arthritis

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Küçük Resim

Tarih

2015

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Makerere Univ, Fac Med

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Background: Epidemiologic data indicates that rheumatoid arthritis is an independent risk factor for cardiovascular disease. Epicardial adipose tissue is a novel cardio-metabolic risk factor. Our aim was to evaluate epicardial fat thickness (EFT) using echocardiography in patients with rheumatoid arthritis compared to healthy control subjects. Secondly, we investigated relationship between epicardial fat thickness and clinical and echocardiographic parameters in patients with rheumatoid arthritis. Method: The study population included 76 consecutive patients with rheumatoid arthritis (64 female; mean age, 53 +/- 11 years, median disease duration, 7.8 years) and 50 healthy subjects as controls (39 female; mean age, 52 +/- 6 years). All patients underwent echocardiography to assess left ventricular diastolic dysfunction, left ventricular hypertrophy and EFT. All values were compared between groups. Results: EFT was higher in rheumatoid arthritis patients than in healthy controls (0.66 +/- 0.20 vs. 0.54 +/- 0.18; p=0.003). Thickness of Intra Ventricular Septum (IVS) (1.1 +/- 0.06 and 9.8 +/- 0.08; p=0.001) and posterior wall (PW) (0.98 +/- 0.05 and 0.93 +/- 0.08; p=0.015) was higher in patients with rheumatoid arthritis compared to healthy controls. Early diastolic myocardiac peak velocity or late diastolic mitral peak velocity (E/A) ratio was lower in rheumatoid arthritis patients compared to healthy patients (1.1 +/- 0.8 and 1.24 +/- 0.1 p=0.001) as well as, E/e' was higher in Rheumatoid arthritis (RA) patients than healthy patients. (E/e': 8.7 +/- 1.6 and 8.0 +/- 1.4 p=0.020). In patients with rheumatoid arthritis, EFT was positively correlated with hypertension and duration of disease and E/e' (r: 0.10, p: 0.010, r: 0.306, p: 0.004 and r: 0.465 p: 0.007 respectively) and EFT was negatively correlated with E/A (r: -. 262 p: 0.022) Conclusion: To our knowledge, this is the first report about epicardial adipose tissue in rheumatoid arthritis patients. Epicardial fat thickness as an indicator of cardiovascular involvement was higher in rheumatoid arthritis patients.

Açıklama

Anahtar Kelimeler

Rheumatoid Arthritis, Epicardial Fat Thickness, Cardiac Involvement

Kaynak

African Health Sciences

WoS Q Değeri

Q3

Scopus Q Değeri

Q3

Cilt

15

Sayı

2

Künye