Intraperitoneal nigella sativa for prevention of postoperative intra-abdominal adhesions in rats

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dc.authorid0000-0002-8212-7149en_US
dc.contributor.authorKarataş, Ahmet
dc.contributor.authorÖzlü, Tülay
dc.contributor.authorÖzyalvaçlı, Gülzade
dc.contributor.authorTosun, Mehmet
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorDönmez, Melahat Emine
dc.contributor.authorTürker, Arzu
dc.date.accessioned2021-06-23T19:35:17Z
dc.date.available2021-06-23T19:35:17Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: To evaluate intraperitoneal administration of Nigella sativa (NS) to prevent postoperative intraperitoneal adhesion (PPA) after surgical manipulation of rat uterine horn. Materials and Methods: Two forms of NS were used in the study (Volatile oil (NSVO) and the ethanolic extract (NSEE)). A total of 50 rats were randomly assigned to the sham group (n = 10), control group (n = 10), NSVO group (n = 10), NSEE group (n = 10), and the Seprafilm group(n = 10). After 14 days, rats were sacrificed. Adhesions were examined macroscopically, and degree of adhesions was scored. A part of horn was excised, and superoxide dismutase (SOD) and glutathione peroxidase activities as well as malondialdehyde levels were evaluated, and histological score was calculated. Results: Total microscopic score of the NSEE groupwas significantly lower than the control group (p = .001) and was marginally significantly lower than the seprafilm group (p = .005). Collagen formation score was higher in the seprafilm group compared to the sham and NSEE groups (p < 0.001, p = .003, respectively). Apoptotic cells were lower in the NSEE group compared to the control group (p=. 003) and also lower in the NSEE and NSVO groups compared to the seprafilm group (p = .001, p < .001, respectively). Only SOD activity was higher in the NSVO and seprafilm groups compared to the control group (p < .001). Conclusion: NSEE form seems to have a possible effect in the prevention of PPAs. This may occur by its effect in decreasing collagen formation and by decreasing apoptosis in the injured tissues. NSVO form seems to induce SOD. Therefore, combined use of NSVO with seprafilm may increase the adhesion preventive effect of seprafilm.en_US
dc.identifier.doi10.3109/08941939.2014.908988
dc.identifier.endpage326en_US
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue6en_US
dc.identifier.pmid24833552en_US
dc.identifier.scopus2-s2.0-84910072531en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage319en_US
dc.identifier.urihttps://doi.org/10.3109/08941939.2014.908988
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7755
dc.identifier.volume27en_US
dc.identifier.wosWOS:000344484200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKarataş, Ahmet
dc.institutionauthorÖzlü, Tülay
dc.institutionauthorÖzyalvaçlı, Gülzade
dc.institutionauthorTosun, Mehmet
dc.institutionauthorÇetinkaya, Ayhan
dc.institutionauthorDönmez, Melahat Emine
dc.institutionauthorTürker, Arzu
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofJournal Of Investigative Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdhesionen_US
dc.subjectNigella Sativaen_US
dc.subjectPeritonealen_US
dc.subjectPostoperativeen_US
dc.subjectEthanolic Extracten_US
dc.subjectVolatile Oilen_US
dc.titleIntraperitoneal nigella sativa for prevention of postoperative intra-abdominal adhesions in ratsen_US
dc.typeArticleen_US

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