Anxiolytic, antioxidant, and neuroprotective effects of goji berry polysaccharides in ovariectomized rats: experimental evidence from behavioral, biochemical, and immunohistochemical analyses

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dc.authorid0000-0002-6793-6888en_US
dc.authorid0000-0002-5509-8717en_US
dc.authorid0000-0001-5245-6294en_US
dc.authorid0000-0002-0000-3768
dc.contributor.authorPehlivan Karakaş, Fatma
dc.contributor.authorCoşkun, Hamit
dc.contributor.authorSoytürk, Hayriye
dc.contributor.authorBozat, Bihter Gökçe
dc.date.accessioned2021-06-23T19:54:44Z
dc.date.available2021-06-23T19:54:44Z
dc.date.issued2020
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractRecent studies have indicated that polysaccharides, the main component of the Lycium barbarum L. fruit, have beneficial effects (e.g., anxiolytic, antioxidant, and neuroprotective) on humans and rodents. However, the effects of different dosages of such polysaccharides on ovariectomized rats and their underlying mechanisms in the brain have not been evaluated in the literature. Here, we aimed to evaluate the effects of the high and low doses of polysaccharides obtained from Lycium barbarum fruits (HD-LBP and LD-LBP, respectively) on anxious behaviors via behavioral (using the OFT and EPM), biochemical (using ELISA), and immunohistochemical (using immunohistochemical staining) measures in detail. Two weeks after ovariectomy, the rats were randomly assigned to either the treatment conditions [control (DW, 3 mL/kg, p.o., per day), LD-LBP (20 mg/kg, 3 mL/kg, p.o., per day), HD-LBP (200 mg/kg, 3 mL/kg, p.o., per day), 17 beta-ES (1 mg/kg, 3 mL/kg, p.o., per day), DZ(1 mg/kg, 3 mL/kg, p.o., per day)] or operation type [SHAM (pseudo-ovariectomized) and OVX (ovariectomized)]. The treatments were applied for 30 consecutive days, and then serum and brain tissue samples of all rats were collected. Biochemical (SOD, CAT, GPX, MDA, and 17 beta-ES) and immunohistochemical (BDNF, SER, and apoptosis) analyses of the samples were performed as well. The rats administered HD-LBP and LD-LBP were less anxious than the control groups. The HD-LBP-treated rats had high levels of SOD and low levels of MDA in their serum samples. Moreover, HD-LBP and drug-treated groups had a high number of SER receptors and BDNF-positive cells and a low number of TUNEL-positive cells in their hippocampal brain tissues. The HD-LBP treatments decrease anxious behavior by increasing antioxidant enzyme activities, hippocampal SER and BDNF neurotransmitter levels and decreasing the TUNEL-positive cell count of ovariectomized rats. Given these findings, we suggest that menopause-induced symptoms of anxiety can be reduced by polysaccharides obtained from goji berry fruits, and that these findings will be beneficial for the production studies of natural herbal-origin antianxiety (anxiolytic) drugs in the future.en_US
dc.identifier.doi10.3906/biy-2003-8
dc.identifier.endpage251en_US
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.issue5en_US
dc.identifier.pmid33110362en_US
dc.identifier.scopus2-s2.0-85092442710en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage238en_US
dc.identifier.trdizinid438466en_US
dc.identifier.urihttps://journals.tubitak.gov.tr/biology/issues/biy-20-44-5/biy-44-5-3-2003-8.pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10630
dc.identifier.volume44en_US
dc.identifier.wosWOS:000582626200003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorPehlivan Karakaş, Fatma
dc.institutionauthorCoşkun, Hamit
dc.institutionauthorBozat, Bihter Gökçe
dc.institutionauthorSoytürk, Hayriye
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLycium barbarum L.en_US
dc.subjectPharmacological Activityen_US
dc.subjectAntioxidant Enzymesen_US
dc.subjectNeurotransmittersen_US
dc.subjectSerotoninen_US
dc.subjectBDNFen_US
dc.subjectELISAen_US
dc.subjectMenopauseen_US
dc.titleAnxiolytic, antioxidant, and neuroprotective effects of goji berry polysaccharides in ovariectomized rats: experimental evidence from behavioral, biochemical, and immunohistochemical analysesen_US
dc.typeArticleen_US

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