Can excessive oxygen cause hyperactive behavior disorder in preterm children? Cognitive effects of hyperoxia in the preterm brain of rats

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dc.authorid0000-0002-3802-0336
dc.authorid0000-0001-5245-6294
dc.authorid0000-0002-0000-3768
dc.authorid0000-0002-8212-7149
dc.authorid0000-0003-2469-9509
dc.contributor.authorDilek, Mustafa
dc.contributor.authorOrallar, Hayriye
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorBozat, Gökçe
dc.contributor.authorPehlivan, Fatma
dc.contributor.authorBekdaş, Mervan
dc.contributor.authorKabakuş, Nimet
dc.date.accessioned2021-06-23T19:50:26Z
dc.date.available2021-06-23T19:50:26Z
dc.date.issued2019
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractThere is a paucity of data on the effects of hyperoxia-induced brain damage on learning and such psychosocial phenomenon as anxiety. Preterm infants encounter hyperoxia within a relatively early stage of life (leaving the intrauterine environment earlier than was expected) and are exposed to high-level hyperoxic stress due to the insufficiency of their antioxidant defense mechanisms. In an experimental rat model, we investigated the effects of early postnatal hyperoxia on learning, anxiety, and depression in the early adulthood period. Rat nestlings (n = 7) were exposed to about 80% oxygen for the first 5 days after birth to create a rat model of hyperoxia, and these nestlings and those of the control group (n = 7) were subjected to behavioral tests (Morris water tank, open-field test, elevated plus maze, and Porsolt test) at 30 days old. Video recordings of the tests were captured, and indices of the tests in the experimental groups were compared with the Mann-Whitney U-test. In the Morris water navigation task, the latency and distance required to locate the platform were greater (P = 0.018 and 0.025, respectively) in the hyperoxia group than in the control group, suggesting that exposure to hyperoxia during the development of the brain can exert a negative effect on the learning function. There was no difference in the time spent in the open center area of the open-field test (anxiety), while the rats in the hyperoxia group spent more time in the enclosed area in the elevated plus maze test, suggesting a higher level of anxiety (P = 0.048). In the Porsolt test, rats in the hyperoxia group moved faster (P = 0.013) and travelled a longer distance (P = 0.048). Although this finding suggests less depressive behavior in the mentioned group, which was contrary to the expectations, this may also explain the tendency of preterm infants to hyperactivity at later ages. Thus, it has been demonstrated experimentally that exposure of neonates to oxygen exceeding physiological needs may cause behavioral problems, such as impaired learning, anxiety, and hyperactivity.en_US
dc.identifier.doi10.1007/s11062-019-09819-3
dc.identifier.endpage265en_US
dc.identifier.issn0090-2977
dc.identifier.issn1573-9007
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85075940292en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage259en_US
dc.identifier.urihttps://doi.org/10.1007/s11062-019-09819-3
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9782
dc.identifier.volume51en_US
dc.identifier.wosWOS:000500342900002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorDilek, Mustafa
dc.institutionauthorOrallar, Hayriye
dc.institutionauthorÇetinkaya, Ayhan
dc.institutionauthorPehlivan, Fatma
dc.institutionauthorBekdaş, Mervan
dc.institutionauthorKabakuş, Nimet
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNeurophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPreterm Birthen_US
dc.subjectHyperoxiaen_US
dc.subjectCognitive Functionen_US
dc.subjectBrain Injury Modelen_US
dc.subjectHyperactive Behavioral Disorderen_US
dc.titleCan excessive oxygen cause hyperactive behavior disorder in preterm children? Cognitive effects of hyperoxia in the preterm brain of ratsen_US
dc.typeArticleen_US

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