Does mean platelet volume/lymphocyte count ratio associate with frailty in type 2 diabetes mellitus?

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dc.authorid0000-0003-2811-0052
dc.authorid0000-0001-7306-5233
dc.authorid0000-0003-4201-9757
dc.authorid0000-0002-9371-0268
dc.contributor.authorBilgin, Satılmış
dc.contributor.authorAktaş, Gülali
dc.contributor.authorKahveci, Gizem
dc.contributor.authorAtak Tel, Burçin Meryem
dc.contributor.authorKurtkulağı, Özgür
dc.contributor.authorDuman Taslamacıoğlu, Tuba
dc.date.accessioned2021-06-23T18:57:09Z
dc.date.available2021-06-23T18:57:09Z
dc.date.issued2021
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractOBJECTIVES: Frailty is a common problem in patients with type 2 diabetes mellitus (T2DM). It is considered to be associated with inflammation. Novel markers derived from hemogram, such as neutrophil/lymphocyte ratio (NLR) and mean platelet volume/lymphocyte ratio (MPVLR), are proposed as inflammatory markers. In present study, we aimed to compare NLR and MPVLR levels of frail patients with T2DM to non-frail diabetic subjects. METHODS: Diabetic subjects were grouped in frail and non-frail groups according to the Edmonton Frail Scale. General characteristics and laboratory data of the frail and non-frail groups were compared. RESULTS: The MPVLR of the frail (3.9 [1.4–13.2] %) group was significantly higher than that of the non-frail (3.4 [1.5–6.9] %) group (p = 0.02). MPVLR was positively and significantly correlated with Edmonton Frail Scale score (r = 0.21, p = 0.03). A MPVLR level greater than 3.41 % has 71 % sensitivity and 51 % specify in predicting frailty. CONCLUSION: We suggest that elevated MPVLR could be a finding that marks frailty in diabetic subjects. Inexpensive and easy-to-assess nature of the MPVLR may be useful in predicting frailty in type 2 diabetic population (Tab. 2, Fig. 1, Ref. 32). Text in PDF www.elis.sken_US
dc.identifier.doi10.4149/BLL_2021_017
dc.identifier.endpage119en_US
dc.identifier.issn0006-9248
dc.identifier.issue2en_US
dc.identifier.pmid33502879en_US
dc.identifier.scopus2-s2.0-85100550002en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage116en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2021_017
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5141
dc.identifier.uri1336-0345
dc.identifier.volume122en_US
dc.identifier.wosWOS:000637614100005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBilgin, Satılmış
dc.institutionauthorAktaş, Gülali
dc.institutionauthorKahveci, Gizem
dc.institutionauthorAtak Tel, Burçin Meryem
dc.institutionauthorKurtkulağı, Özgür
dc.language.isoenen_US
dc.publisherComenius University in Bratislavaen_US
dc.relation.ispartofBratislava Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFrailtyen_US
dc.subjectInflammationen_US
dc.subjectMean Platelet Volume/Lymphocyte Ratioen_US
dc.subjectType 2 Diabetes Mellitusen_US
dc.titleDoes mean platelet volume/lymphocyte count ratio associate with frailty in type 2 diabetes mellitus?en_US
dc.typeArticleen_US

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