Dental and temporomandibular joint alterations in rheumatoid arthritis patients and their association with salivary oxidative stress

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dc.authorid0000-0002-1492-6897en_US
dc.authorid0000-0003-4260-2520en_US
dc.authorid0000-0002-4205-861Xen_US
dc.authorid0000-0003-1046-8208en_US
dc.authorid0000-0002-4635-5179en_US
dc.contributor.authorYaman, Deniz
dc.contributor.authorBulut, Duygu Göller
dc.contributor.authorUstaoğlu, Gülbahar
dc.contributor.authorAvcı, Emre
dc.contributor.authorTaşçı, Murat
dc.date.accessioned2023-06-08T07:30:35Z
dc.date.available2023-06-08T07:30:35Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Diş Hekimliği Fakültesi, Ağız Diş ve Çene Cerrahisi Ana Bilim Dalıen_US
dc.description.abstractBackground/aim: Rheumatoid arthritis (RA) is the most extensive inflammatory arthritis causing permanent deformities in the joint. Increasing evidence suggests that oxidative stress is a substantial factor in the pathogenesis of RA. This study aimed to examine the salivary oxidant-antioxidant status of RA and control groups and to compare these biomarkers by correlating them with disease activity, acute phase reactants, and clinical findings. Materials and methods: Age and sex-matched 60 participants including 30 patients with RA and 30 control (50 females, 10 males; mean age: 42.62 +/- 10.89 years) were evaluated. RA disease activity and severity were evaluated by the disease activity score 28-C reactive protein (DAS 28-CRP). Rheumatoid factor (RF) positivity, anticitrullinated protein antibodies (ACPA) positivity, erythrocyte sedimentation rate (ESR), CRP, tender and swollen joint counts, and medical treatment regimens of the patients (glucocorticoids, conventional or biologic disease-modifying antirheumatic drugs) were recorded. In the radiographic examination, dental findings, and bone alterations of the temporomandibular joint (TMJ) were recorded and compared for both groups. Saliva samples were obtained for analysis of total antioxidant status (TAS), total oxidant status (TOS), arylesterase (ARE), and oxidative stress index (OSI) levels. The data analysis was conducted by independent sample t-test and chi-square test. Results: Condylar erosion was the most common radiographic change in TMJ of RA patients. Osteophyte formation was a prominent finding in the control group. Lower TAS and higher OSI levels were found in RA patients compared with controls (p = 0.013; p = 0.029, respectively). The effect of DAS 28-CRP score on the levels of oxidative stress biomarkers in RA patients was not significant. Conclusion: Oxidative stress causes tissue damage in response to excessive mechanical loading, which in turn promotes TMD. However, disease activity has not a prominent impact on the salivary oxidative stress status of RA patients.en_US
dc.identifier.citationYaman, D., Bulut, D. G., Ustaoğlu, G., Avci, E., & TAŞÇI, M. (2021). Dental and temporomandibular joint alterations in rheumatoid arthritis patients andtheir association with salivary oxidative stress. Turkish journal of medical sciences, 51(4), 2073-2079.en_US
dc.identifier.doi10.3906/sag-2102-260
dc.identifier.endpage2080en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue4en_US
dc.identifier.pmid34013708en_US
dc.identifier.scopus2-s2.0-85109412448en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2073en_US
dc.identifier.trdizinid480954en_US
dc.identifier.urihttp://dx.doi.org/10.3906/sag-2102-260
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11076
dc.identifier.volume51en_US
dc.identifier.wosWOS:000691544700061en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYaman, Deniz
dc.institutionauthorBulut, Duygu Göller
dc.institutionauthorUstaoğlu, Gülbahar
dc.institutionauthorTaşçı, Murat
dc.language.isoenen_US
dc.publisherTUBITAK Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOxidative Stressen_US
dc.subjectRheumatoid Arthritisen_US
dc.subjectSalivaen_US
dc.subjectTemporomandibular Joint Disordersen_US
dc.titleDental and temporomandibular joint alterations in rheumatoid arthritis patients and their association with salivary oxidative stressen_US
dc.typeArticleen_US

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