Serum levels of omentin in pseudoexfoliation syndrome

Purpose: Omentin, a member of the adipocytokines family, is derived from adipose tissue and a lower level of serum omentin is considered as a metabolic risk factor. The aim of the present study is to evaluate the serum levels of omentin in patients with pseudoexfoliation syndrome (PES). Materials and Methods: Patients without any systemic or ocular disease other than PES were included in the study. Age-matched and sex-matched healthy volunteers without PES were accepted as a control group. After detailed ophthalmologic examination, blood samples were obtained from a forearm vein. Serum levels of omentin were determined by the method of enzyme-linked immunosorbent assay. Results: The mean age of the PES group (12 females, 12 males, n = 24) was 75.2 +/- 8.4 years, and the control group (10 females, 10 males, n = 20) was 75 +/- 6.7 years. There was no difference between the groups in terms of age (P = 0.93) and sex (P = 0.9). The mean serum levels of omentin in the PES group were 801.5 +/- 317.1 ng/mL and in the control group were 1150.1 +/- 584.1 ng/mL. The mean serum omentin levels were significantly lower in patients with PES (P = 0.016). Conclusion: Lower levels of serum omentin in patients with PES compared with healthy subjects may support the theory of systemic nature of the disease.