Association of toll-like receptors 2, 3, and 4 genes polymorphisms with periapical pathosis risk

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dc.authorid0000-0003-4716-948X
dc.authorid0000-0002-5099-5128
dc.authorid0000-0002-9336-2865
dc.contributor.authorÖzan, Ülkü
dc.contributor.authorOcak, Zeynep
dc.contributor.authorÖzan, Fatih
dc.contributor.authorOktay, Elif-Aybala
dc.contributor.authorToptaş, Orçun
dc.contributor.authorŞahman, Halil
dc.contributor.authorYıkılgan, İhsan
dc.contributor.authorOruçoğlu, Hasan
dc.date.accessioned2021-06-23T19:43:21Z
dc.date.available2021-06-23T19:43:21Z
dc.date.issued2016
dc.departmentBAİBÜ, Diş Hekimliği Fakültesi, Endodonti Ana Bilim Dalıen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.departmentBAİBÜ, Diş Hekimliği Fakültesi, Ağız Diş ve Çene Cerrahisi Ana Bilim Dalı
dc.departmentBAİBÜ, Diş Hekimliği Fakültesi, Ağız, Diş ve Çene Radyolojisi Ana Bilim Dalı
dc.description.abstractBackground: The aim of this study was to investigate the role of gene variations of Toll-like receptors (TLR) 2, 3, and 4 on genetic susceptibility to periapical pathosis. Material and Methods: One hundred patients were included in the study and divided into two groups as follows; Control Group (n=50) that have root canal treatment and no periapical lesion, Patient Group (n=50) that have root canal treatment and periapical lesion. TLR2 Arg753Gln, TLR3 (c.1377C/T) and TLR4 Asp299Gly and Thr399Ile polymorphisms were genotyped by using PCR-RFLP. Genotypical analysis of control and patient groups were investigated to disclose whether there is any association between periapical lesions and gene variations. Results: There are no significant statistical differences between control and patient groups according to TLR 2 and 4 gene sequence. On the contrary, CC allele detected 74% for TLR 3 in patient group, and this difference was found to be statistically significant (p < 0.005). Conclusions: According to these results, it can be suggested that patients with Toll-like receptor 3 gene polymorphisms could be susceptible to periapical pathosis.en_US
dc.identifier.doi10.4317/medoral.21081
dc.identifier.endpageE412en_US
dc.identifier.issn1698-6946
dc.identifier.issue4en_US
dc.identifier.pmid27031066en_US
dc.identifier.scopus2-s2.0-84985914492en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE408en_US
dc.identifier.urihttps://doi.org/10.4317/medoral.21081
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8757
dc.identifier.volume21en_US
dc.identifier.wosWOS:000385028200002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzan, Ülkü
dc.institutionauthorOruçoğlu, Hasan
dc.institutionauthorOcak, Zeynep
dc.institutionauthorÖzan, Fatih
dc.institutionauthorToptaş, Orçun
dc.institutionauthorŞahman, Halil
dc.language.isoenen_US
dc.publisherMedicina Oral S Len_US
dc.relation.ispartofMedicina Oral Patologia Oral Y Cirugia Bucalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectToll-Like Receptorsen_US
dc.subjectPeriapical Pathosisen_US
dc.subjectEndodonticsen_US
dc.titleAssociation of toll-like receptors 2, 3, and 4 genes polymorphisms with periapical pathosis risken_US
dc.typeArticleen_US

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Ağız Diş ve Çene Cerrahisi Ana Bilim Dalı Koleksiyonu
Ağız Diş ve Çene Radyolojisi Ana Bilim Dalı Koleksiyonu
Endodonti Ana Bilim Dalı Koleksiyonu
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