Evaluation and comparison of the effects of artesunate, dexamethasone, and tacrolimus on sciatic nerve regeneration

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dc.authorid0000-0002-0062-4054
dc.authorid0000-0002-5099-5128
dc.authorid0000-0002-1065-3254
dc.authorid0000-0001-9613-5564
dc.authorid0000-0001-8616-832X
dc.contributor.authorUzun, Tuğçenur
dc.contributor.authorToptaş, Orçun
dc.contributor.authorSaylan, Aslıhan
dc.contributor.authorCarver, Hande
dc.contributor.authorTürkoğlu, Şule Aydın
dc.date.accessioned2021-06-23T19:51:44Z
dc.date.available2021-06-23T19:51:44Z
dc.date.issued2019
dc.departmentBAİBÜ, Diş Hekimliği Fakültesi, Ağız Diş ve Çene Cerrahisi Ana Bilim Dalıen_US
dc.descriptionJoint Congress of the International-Association-of-Oral-and-Maxillofacial-Surgeons and the Oral-and-Maxillofacial-Surgery-Society-of-Turkey -- MAY 09-13, 2018 -- Antalya, TURKEYen_US
dc.description.abstractPurpose: To examine the effect of topical artesunate treatment on peripheral nerve regeneration and compare it with the effects of topical tacrolimus and dexamethasone on nerve regeneration. Materials and Methods: Thirty-two Wistar albino rats were used in this study. The rats were divided into 6 groups: sham, saline, petrolatum, artesunate, tacrolimus, and dexamethasone. A compression injury was generated in the right sciatic nerve in all groups except the sham group. In the sham group, the nerve was dissected but compression was not applied. In the groups in which compression was applied, the agents were absorbed through resorbable gelatin sponges applied to the injured region. At the end of 4 weeks, walking analysis, electromyographic measurements, and histopathologic examinations were conducted. Results: When the sciatic function index and electrophysiologic measurements were evaluated, artesunate, tacrolimus, and dexamethasone exhibited positive effects on nerve regeneration (P <.05); there were no significant differences among these 3 agents (P >.05). Histopathologic examination showed that artesunate decreased fibrosis scores and inflammation and increased the diameter of myelinated axons; tacrolimus decreased fibroblast scores; and dexamethasone only decreased fibrosis scores (P <.05). Immunohistochemical analysis showed that the artesunate and dexamethasone groups had more positive immunoreactivity to nerve growth factor than did the saline group (P <.05). Conclusions: Topical artesunate treatment had a positive effect on peripheral nerve regeneration. There were no relevant differences between the topical forms of dexamethasone and tacrolimus for peripheral nerve regeneration. (C) 2018 American Association of Oral and Maxillofacial Surgeonsen_US
dc.description.sponsorshipOral & Maxillofacial Surg Soc Turkey, Int Assoc Oral & Maxillofacial Surgen_US
dc.identifier.doi10.1016/j.joms.2018.12.019
dc.identifier.issn0278-2391
dc.identifier.issn1531-5053
dc.identifier.issue5en_US
dc.identifier.pmid30689960en_US
dc.identifier.scopus2-s2.0-85062402552en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.joms.2018.12.019
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10037
dc.identifier.volume77en_US
dc.identifier.wosWOS:000466147700045en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUzun, Tuğçenur
dc.institutionauthorToptaş, Orçun
dc.institutionauthorSaylan, Aslıhan
dc.institutionauthorCarver, Hande
dc.institutionauthorTürkoğlu, Şule Aydın
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal Of Oral And Maxillofacial Surgeryen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSciatic Nerveen_US
dc.subjectElectromyographic (EMG) Measurement
dc.titleEvaluation and comparison of the effects of artesunate, dexamethasone, and tacrolimus on sciatic nerve regenerationen_US
dc.typeConference Objecten_US

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