Elution characteristics and mechanical properties of calcium sulfate-loaded bone cement containing teicoplanin

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dc.authorid0000-0002-8744-5082
dc.authorid0000-0003-4859-5616
dc.contributor.authorTüzüner, Tolga
dc.contributor.authorUygur, İlyas
dc.contributor.authorŞencan, İrfan
dc.contributor.authorHaklar, Uğur
dc.contributor.authorOktaş, Birhan
dc.contributor.authorÖzdemir, Davut
dc.date.accessioned2021-06-23T19:20:25Z
dc.date.available2021-06-23T19:20:25Z
dc.date.issued2007
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBackground. Acrylic bone cement is the most widely used drug delivery system clinically. It has already been shown that antibiotic release is significantly increased when calcium sulfate-loaded acrylic bone cement is used. However, there is no information yet about the mechanical responses of these composite materials. Thus, the purpose of this study was to investigate the effect of calcium sulfate on the elution characteristics and mechanical behavior of teicoplanin-loaded acrylic bone cement. Methods. Four groups of acrylic bone cements (GI, GII, GIII, GIV) were prepared using the same liquid/powder ratios. After mixing, the bone cement and additive mixtures were packed into different-type molds to prepare the specimens for the elution and mechanical tests. All of the specimens were tested for two conditions (dry and human plasma solution). The mechanical tests included the setting time (hardness) and tensile, bending, and compression strengths. The fracture surfaces of the failed samples were also examined by scanning electron microscopy. Results. Teicoplanin release in the calcium sulfate powder added groups (GIII and GIV) was higher than that of GII. When the calcium sulfate and teicoplanin were added on acrylic bone cement, the compressive, bending and tensile strength, hardness values, and elastic modulus decreased. Also, further reductions were evident in human plasma solution. Conclusions. Although mechanical properties of tested specimens decreased, all of the results obtained were higher than those required by the American Society for Testing and Materials Standards, but further investigations are necessary before making definitive statements for clinical applications.en_US
dc.identifier.doi10.1007/s00776-006-1107-9
dc.identifier.endpage177en_US
dc.identifier.issn0949-2658
dc.identifier.issue2en_US
dc.identifier.pmid17393273en_US
dc.identifier.scopus2-s2.0-34248233579en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage170en_US
dc.identifier.urihttps://doi.org/10.1007/s00776-006-1107-9
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6112
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0949265815324258
dc.identifier.volume12en_US
dc.identifier.wosWOS:000245296000012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTüzüner, Tolga
dc.institutionauthorUygur, İlyas
dc.institutionauthorŞencan, İrfan
dc.institutionauthorOktaş, Birhan
dc.institutionauthorÖzdemir, Davut
dc.language.isoenen_US
dc.publisherSpringer Tokyoen_US
dc.relation.ispartofJournal Of Orthopaedic Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone cementen_US
dc.titleElution characteristics and mechanical properties of calcium sulfate-loaded bone cement containing teicoplaninen_US
dc.typeArticleen_US

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