Protective effects of rosmarinic add on doxorubicin-induced testicular damage

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dc.authorid0000-0002-8212-7149en_US
dc.authorid0000-0002-6839-2632en_US
dc.authorid0000-0002-4313-8478
dc.authorid0000-0002-8317-7092
dc.authorid0000-0002-8212-7149
dc.contributor.authorÜyetürk, Ümmügül
dc.contributor.authorÜyetürk, Uğur
dc.contributor.authorFırat, Tülin
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorTekçe, Buket Kın
dc.contributor.authorÇakır, Serkan
dc.date.accessioned2021-06-23T19:36:36Z
dc.date.available2021-06-23T19:36:36Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: We investigated the protective effects of rosmarinic acid (RA) on testicular damage induced by doxorubicin (DXR) in rats. Methods: In total, 21 rats were divided into 3 groups: the control group that received no treatment, the DXR group that received intraperitoneal (i.p.) DXR on day 7 and the DXR + RA group that received intra-gastric RA for 10 days with i.p. DXR on day 7. The rats were sacrificed on day 11 for histological and biochemical analyses. To assess oxidative damage, glutathione peroxidase (GPx) and malondialdehyde (MDA) levels were measured. Results: The median modified Johnsen score of the DXR + RA group was higher than that of the DXR group (p = 0.002). The rats with the narrowest seminiferous tubules were in the DXR group (0.17 +/- 0.03), and the difference between the DXR + RA and DXR groups was statistically significant (p = 0.002). The number of apoptotic cells in the DXR group was significantly higher than that in the control group, and there were significantly fewer apoptotic cells in the DXR + RA group than in the DXR group (p = 0.002). The MDA level was lowest in the control group and highest in the DXR group, and the level observed in the DXR + RA group significantly lower than that in the DXR group (p = 0.002). The GPx level was highest in the control group, with the level observed in the DXR + RA group significantly higher than that in the DXR group (p = 0.002). The testosterone level was lowest in the DXR group and highest in the control group, and that observed in the DXR + RA group was significantly higher than that in the DXR group (p = 0.018). Conclusions: RA can correct DXR-induced testicular damage through its antioxidant properties. However, the mechanism underlying the effects of RA requires further investigation, and long-term and comparative human studies are also needed. (C) 2014 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000365727
dc.identifier.endpage12en_US
dc.identifier.issn0009-3157
dc.identifier.issn1421-9794
dc.identifier.issue1en_US
dc.identifier.pmid25301265en_US
dc.identifier.scopus2-s2.0-84929572421en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage7en_US
dc.identifier.urihttps://doi.org/10.1159/000365727
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8024
dc.identifier.volume60en_US
dc.identifier.wosWOS:000346040700002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÜyetürk, Ümmügül
dc.institutionauthorÜyetürk, Uğur
dc.institutionauthorFırat, Tülin
dc.institutionauthorÇetinkaya, Ayhan
dc.institutionauthorTekçe, Buket Kın
dc.institutionauthorÇakır, Serkan
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofChemotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTesticular damageen_US
dc.subjectRosmarinic acidSen_US
dc.subjectDoxorubicinen_US
dc.subjectRaten_US
dc.titleProtective effects of rosmarinic add on doxorubicin-induced testicular damageen_US
dc.typeArticleen_US

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