The effect of astaxanthine on ischemia-reperfusion injury in a rat model

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dc.authorid0000-0002-3363-8364en_US
dc.authorid0000-0002-7213-5647en_US
dc.authorid0000-0002-0045-7989en_US
dc.authorid0000-0002-8317-7092en_US
dc.authorid0000-0002-4060-3354en_US
dc.authorid0000-0001-9506-4370en_US
dc.contributor.authorDurukan, Yasin
dc.contributor.authorBala, Mehmet Murat
dc.contributor.authorŞahin, Abdullah Alper
dc.contributor.authorFırat, Tülin
dc.contributor.authorBuğdaycı, Güler
dc.contributor.authorÖzturan, Kutay Engin
dc.date.accessioned2023-09-07T06:30:58Z
dc.date.available2023-09-07T06:30:58Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: We aimed to compare biochemical and histopathological findings of astaxanthin's potential effects on oxidative stress in ischemia/reperfusion damage (I/R). Methods: Thirty-two rats were randomly divided into four groups: control group; I/R group; I/ R + treatment group; drug group. Astaxanthin was orally administered to groups C and D for 14 days. In groups B and C, the femoral artery was clamped for 2 h to form ischemia. The clamp was opened, and reperfusion was performed for 1 h. In all groups, 4 ml of blood sample through intracardiac puncture and gastrocnemius muscle tissue samples were collected. Serum and tissue samples were analyzed by measuring malondialdehyde (MDA), superoxide dismutase (SOD), total antioxidant capacity (TAC), and total oxidative level (TOL). Necrosis, inflammation, and caspase-3 in muscle tissue collected for histopathological examination were evaluated. Results: Tissue MDA, SOD and TOL values significantly differed between groups. Serum MDA, SOD, TOL and TAC values significantly differed between groups. On necrosis examination, there was a significant difference between groups B and C. Although signs of inflammation significantly differed between groups, there was no significant difference between groups A and C and groups A and D. Although there was a significant difference in caspase-3 results between groups, there was no significant difference between groups A and C. Conclusions: The use of astaxanthin before and after surgery showed preventive or therapeutic effects against I/R damage. (C) 2021 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.en_US
dc.identifier.citationDurukan, Y., Bala, M. M., Şahin, A. A., Fırat, T., Buğdaycı, G., & Özturan, K. E. (2022). The effect of astaxanthine on ischemia-reperfusion injury in a rat model. Journal of Orthopaedic Science, 27(5), 1132-1138.en_US
dc.identifier.doi10.1016/j.jos.2021.05.014
dc.identifier.endpage1138en_US
dc.identifier.issn0949-2658
dc.identifier.issn1436-2023
dc.identifier.issue5en_US
dc.identifier.pmid34384658en_US
dc.identifier.scopus2-s2.0-85112215986en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1132en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.jos.2021.05.014
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11670
dc.identifier.volume27en_US
dc.identifier.wosWOS:000890114800029en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorFırat, Tülin
dc.institutionauthorBuğdaycı, Güler
dc.institutionauthorÖzturan, Kutay Engin
dc.language.isoenen_US
dc.publisherElseiveren_US
dc.relation.ispartofJournal of Orthopaedic Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAstaxanthinen_US
dc.subjectIschemia/Reperfusionen_US
dc.subjectOxidative Stressen_US
dc.subjectSkeletal-Muscleen_US
dc.subjectDamageen_US
dc.subjectGenotoxicityen_US
dc.titleThe effect of astaxanthine on ischemia-reperfusion injury in a rat modelen_US
dc.typeArticleen_US

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