Capsaicin attenuates excitotoxic-induced neonatal brain injury and brain mast cell-mediated neuroinflammation in newborn rats

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dc.authorid0000-0002-1795-5677en_US
dc.authorid0000-0002-3802-0336en_US
dc.authorid0000-0001-9261-2634en_US
dc.authorid0000-0001-7035-3336en_US
dc.authorid0000-0002-1065-3254en_US
dc.authorid0000-0001-6768-1275en_US
dc.contributor.authorKılınç, Yasemin Baranoğlu
dc.contributor.authorDilek, Mustafa
dc.contributor.authorKılınç, Erkan
dc.contributor.authorTorun, İbrahim Ethem
dc.contributor.authorŞaylan, Aslıhan
dc.contributor.authorDüzcü, Selma Erdoğan
dc.date.accessioned2023-08-18T10:52:07Z
dc.date.available2023-08-18T10:52:07Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionBolu Abant Izzet Baysal University Scien-tific Research Funden_US
dc.description.abstractExcitotoxicity and neuroinflammation are key contributors to perinatal brain injuries. Capsaicin, an active ingredient of chili peppers, is a potent exogenous agonist for transient receptor potential vanilloid 1 receptors. Although the neuroprotective and anti-inflammatory effects of capsaicin are well-documented, its effects on excitotoxic-induced neonatal brain injury and neuroinflammation have not previously been investigated. The aim of this study was to investigate the effects of capsaicin on brain damage, brain mast cells, and inflammatory mediators in a model of ibotenate-induced excitotoxic brain injury in neonatal rats. P5 rat-pups were intraperitoneally injected with vehicle, 0.2-, 1-, and 5-mg/kg doses of capsaicin, or the NMDA (N-methyl-D-aspartate) receptor antagonist MK-801 (dizocilpine), 30 min before intracerebral injection of 10 mu g ibotenate. The naive-control group received no substance administration. The rat pups were sacrificed one or five days after ibotenate injection. Levels of activin A and interleukin (IL)-1 beta, IL-6, and IL-10 in brain tissue were measured using the enzyme-linked immunosorbent assay method. Cortex and white matter thicknesses, white matter lesion size, and mast cells were evaluated in brain sections stained with cresyl-violet or toluidineblue.Capsaicin improved ibotenate-induced white matter lesions and cerebral white and gray matter thicknesses in a dose-dependent manner. In addition, it suppressed the degranulation and increased number of brain mast cells induced by ibotenate. Capsaicin also reduced the excitotoxic-induced production of neuronal survival factor activin A and of the pro-inflammatory cytokines IL-1 beta, and IL-6 in brain tissue. However, IL-10 levels were not altered by the treatments. MK-801, as a positive control, reversed all these ibotenate-induced changes, further confirming the success of the model. Our findings provide, for the first time, evidence for the therapeutic effects of capsaicin against excitotoxicinduced neonatal brain injury and brain mast cell-mediated neuroinflammation. Capsaicin may therefore be a promising candidate in the prevention and/or reduction of neonatal brain damage.en_US
dc.description.sponsorshipBolu Abant Izzet Baysal University Scien-tific Research Fund [2019.08.23.1433]en_US
dc.identifier.citationKilinc, Y. B., Dilek, M., Kilinc, E., Torun, I. E., Saylan, A., & Duzcu, S. E. (2023). Capsaicin attenuates excitotoxic-induced neonatal brain injury and brain mast cell-mediated neuroinflammation in newborn rats. Chemico-Biological Interactions, 376, 110450.en_US
dc.identifier.doi10.1016/j.cbi.2023.110450
dc.identifier.endpage8en_US
dc.identifier.issn0009-2797
dc.identifier.issn1872-7786
dc.identifier.pmid36925032en_US
dc.identifier.scopus2-s2.0-85150415084en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.cbi.2023.110450
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11576
dc.identifier.volume376en_US
dc.identifier.wosWOS:000974429500001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDilek, Mustafa
dc.institutionauthorKılınç, Erkan
dc.institutionauthorTorun, İbrahim Ethem
dc.institutionauthorŞaylan, Aslıhan
dc.institutionauthorDüzcü, Selma Erdoğan
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofChemico-Biological Interactionsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCapsaicinen_US
dc.subjectNeonatal Brain Injuryen_US
dc.subjectExcitotoxicityen_US
dc.subjectNeuroinflammationen_US
dc.subjectBrain Mast Cellsen_US
dc.subjectExcitatory Amino-Acidsen_US
dc.titleCapsaicin attenuates excitotoxic-induced neonatal brain injury and brain mast cell-mediated neuroinflammation in newborn ratsen_US
dc.typeArticleen_US

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