Linezolid versus vancomycin for the treatment of methicillin-resistant staphylococcus aureus keratitis in rabbits

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dc.authorid0000-0003-1657-9099en_US
dc.authorid0000-0001-6133-9604en_US
dc.contributor.authorTaş, Tekin
dc.contributor.authorKüçükbayrak, Abdülkadir
dc.contributor.authorHakyemez, İsmail Necati
dc.contributor.authorMengeloğlu, Fırat Zafer
dc.contributor.authorSimavlı, Hüseyin
dc.contributor.authorÖzyalvaçlı, Gülzade
dc.contributor.authorErdurmuş, Mesut
dc.date.accessioned2021-06-23T19:34:25Z
dc.date.available2021-06-23T19:34:25Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: To compare the efficacy of topical linezolid (LZD) 1 mg/mL or 2 mg/mL to vancomycin (VA) 50 mg/mL for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) keratitis in rabbits. Methods: One hundred colony-forming unit (CFU) MRSA bacteria were injected intrastromally into rabbit corneas. Sixteen hours after the injection, 24 rabbits were randomly divided into 4 groups. Rabbit eyes were treated with 1 drop of topical LZD 1 mg/mL, LZD 2 mg/mL, VA 50 mg/mL, or isotonic saline every 15 minutes for 5 doses and then every 30 minutes for 14 doses. Eyes were examined before and after the treatment using slit-lamp biomicroscopy by 2 observers blinded to the study for the determination of clinical severity. Then, corneas were harvested for the quantification of bacteria and histopathology. Results: There were no differences in clinical severity among the groups before and after the treatment in each eye. The mean CFU x 10(6) of MRSA recovered from the LZD 1 mg/mL, LZD 2 mg/mL, and VA 50 mg/mL groups were significantly lower than that recovered from corneas treated with isotonic saline. There was no statistically significant difference among the treatment groups in terms of CFU x 10(6). Epithelial erosion in the VA 50 mg/mL group was significantly worse than that in the other groups. LZD 2 mg/mL group had the lowest mean epithelial erosion values. Conclusions: Topical LZD showed activity against MRSA that was comparable to fortified VA in this experimental keratitis model.en_US
dc.identifier.doi10.1097/ICO.0b013e3182912ffa
dc.identifier.endpage1057en_US
dc.identifier.issn0277-3740
dc.identifier.issn1536-4798
dc.identifier.issue7en_US
dc.identifier.pmid23665649en_US
dc.identifier.scopus2-s2.0-84879088024en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1052en_US
dc.identifier.urihttps://doi.org/10.1097/ICO.0b013e3182912ffa
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7504
dc.identifier.volume32en_US
dc.identifier.wosWOS:000330356600045en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTaş, Tekin
dc.institutionauthorKüçükbayrak, Abdülkadir
dc.institutionauthorHakyemez, İsmail Necati
dc.institutionauthorMengeloğlu, Fırat Zafer
dc.institutionauthorSimavlı, Hüseyin
dc.institutionauthorÖzyalvaçlı, Gülzade
dc.institutionauthorErdurmuş, Mesut
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofCorneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLinezoliden_US
dc.subjectVancomycinen_US
dc.subjectMRSA Keratitisen_US
dc.titleLinezolid versus vancomycin for the treatment of methicillin-resistant staphylococcus aureus keratitis in rabbitsen_US
dc.typeArticleen_US

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