Influence of circadian rhythm on the efficacy of the hepatitis B vaccination

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dc.authorid0000-0003-1514-1685en_US
dc.authorid0000-0002-2860-1794
dc.contributor.authorKarabay, Oğuz
dc.contributor.authorTemel, Atilla
dc.contributor.authorKöker, Ahmet Gökhan
dc.contributor.authorTokel, Meltem
dc.contributor.authorCeyhan, Muhammet
dc.contributor.authorKoçoğlu, Esra
dc.date.accessioned2021-06-23T19:25:55Z
dc.date.available2021-06-23T19:25:55Z
dc.date.issued2008
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractVaccination is the most effective way to protect HBV infection [1,2]. Many factors (genetic features, gender, HLA structure, obesity, smoking and T cell subgroups) may influence response to the hepatitis B vaccination [3]. Generally, events affecting the immune system can be expected to have an effect on the response to vaccination. The daylight cycle constitutes the circadian rhythm in human beings. The suprachiasmatic nucleus in the hypothalamus serves as a circadian clock. The immune system also exhibits a circadian rhythm [4]. The major influence of the circadian rhythm on cellular and humoral immune response is mediated by cortisol and melatonin in humans [5]. Hence, it was hypothesized that vaccination given in the morning or in the evening might affect the immune response to the vaccine. Since no previous studies in the literature related with the subject have been found in English, the influence of daily circadian rhythm on hepatitis B vaccination was investigated in this study.en_US
dc.identifier.doi10.1016/j.vaccine.2007.12.046
dc.identifier.endpage1144en_US
dc.identifier.issn0264-410X
dc.identifier.issue9en_US
dc.identifier.pmid18255201en_US
dc.identifier.scopus2-s2.0-39149107079en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1143en_US
dc.identifier.urihttps://doi.org/10.1016/j.vaccine.2007.12.046
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6322
dc.identifier.volume26en_US
dc.identifier.wosWOS:000254081600001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKarabay, Oğuz
dc.language.isoenen_US
dc.publisherElsevier Science Ltd.en_US
dc.relation.ispartofVaccineen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCircadian Rhythmen_US
dc.subjectHepatitis Ben_US
dc.subjectVaccinationen_US
dc.titleInfluence of circadian rhythm on the efficacy of the hepatitis B vaccinationen_US
dc.typeLetteren_US

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