Influence of circadian rhythm on the efficacy of the hepatitis B vaccination
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Dosyalar
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Ltd.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Vaccination is the most effective way to protect HBV infection [1,2]. Many factors (genetic features, gender, HLA
structure, obesity, smoking and T cell subgroups) may influence response to the hepatitis B vaccination [3]. Generally,
events affecting the immune system can be expected to
have an effect on the response to vaccination. The daylight
cycle constitutes the circadian rhythm in human beings. The
suprachiasmatic nucleus in the hypothalamus serves as a circadian clock. The immune system also exhibits a circadian
rhythm [4]. The major influence of the circadian rhythm
on cellular and humoral immune response is mediated by
cortisol and melatonin in humans [5]. Hence, it was hypothesized that vaccination given in the morning or in the evening
might affect the immune response to the vaccine. Since no
previous studies in the literature related with the subject
have been found in English, the influence of daily circadian
rhythm on hepatitis B vaccination was investigated in this
study.
Açıklama
Anahtar Kelimeler
Circadian Rhythm, Hepatitis B, Vaccination
Kaynak
Vaccine
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
26
Sayı
9
