Montelukast protects axial pattern rat skin flaps against ischemia/reperfusion injury

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dc.authorid0000-0002-1706-4444en_US
dc.authorid0000-0002-4060-3354en_US
dc.authorid0000-0003-2696-8274
dc.authorid0000-0001-7965-6229
dc.contributor.authorGideroğlu, Kaan
dc.contributor.authorYılmaz, Fahrettin
dc.contributor.authorAksoy, Fadullah
dc.contributor.authorBuğdaycı, Güler
dc.contributor.authorSağlam, İbrahim
dc.contributor.authorYılmaz, Fahri
dc.date.accessioned2021-06-23T19:26:03Z
dc.date.available2021-06-23T19:26:03Z
dc.date.issued2009
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractBackground. Recent studies have shown that neutrophils play an important role in the pathogenesis of reperfusion injury. Using an inferior epigastric artery skin flap as a flap ischemia/reperfusion (I/R) injury model, we investigated whether the administration of montelukast sodium, a selective reversible cysteinyl leukotriene 1 (Cy5LT1) receptor antagonist, decreases neutrophil infiltration and promotes flap survival. Methods. Eighteen rats were used and randomly divided into three groups (n = 6 for each group). Group I was the sham group and did not undergo ischemic insult; rather, normal saline (1mL) was administrated intraperitonealy (i.p.) 30 min before surgery and continued for 6 d. Group II (control) and Group III (montelukast) underwent 12 h of ischemic insult. For Group II, normal saline (1mL) was injected i.p. 30 min before the surgery and immediately before reperfusion, and this continued for 6 d. In Group III, 1mL of montelukast (10mg/kg) was injected i.p. and continued for 6 d. Malondialdehyde (MDA) and glutathione (GSH) levels and myeloperoxidase (MPO) enzyme activities were investigated. Histological evaluation was made to investigate the tissue neutrophil count. Survival areas were assessed at 7 d postoperatively. Results. Group III (montelukast- treated) showed a significantly higher survival rate than Group II (control) (P = 0.029) but a lower survival rate than Group I (sham). Histological and biochemical assays corroborated this data. Conclusion. This study suggests that montelukast CysLT1 receptor antagonist montelukast reversed I/R-induced oxidant responses and improved flap survival by inhibiting neutrophil infiltration and balancing oxidant and antioxidant status. (C) 2009 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jss.2008.07.031
dc.identifier.endpage186en_US
dc.identifier.issn0022-4804
dc.identifier.issn1095-8673
dc.identifier.issue2en_US
dc.identifier.pmid19589545en_US
dc.identifier.scopus2-s2.0-70450238022en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage181en_US
dc.identifier.urihttps://doi.org/10.1016/j.jss.2008.07.031
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6393
dc.identifier.volume157en_US
dc.identifier.wosWOS:000276650200008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGideroğlu, Kaan
dc.institutionauthorYılmaz, Fahrettin
dc.institutionauthorBuğdaycı, Güler
dc.institutionauthorSağlam, İbrahim
dc.institutionauthorYılmaz, Fahri
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofJournal Of Surgical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMontelukasten_US
dc.subjectIschemia Reperfusionen_US
dc.subjectInjuryen_US
dc.subjectAxial Pattern Skin Flapen_US
dc.titleMontelukast protects axial pattern rat skin flaps against ischemia/reperfusion injuryen_US
dc.typeArticleen_US

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