Comparison of histopathological effects of thymoquinone and local nasal corticosteroids in allergic rhinitis in a rabbit model

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dc.authorid0000-0002-6223-4254
dc.authorid0000-0003-2099-9395
dc.authorid0000-0002-4552-0048
dc.authorid0000-0002-8317-7092
dc.authorid0000-0002-8993-8008
dc.contributor.authorYurttaş, Veysel
dc.contributor.authorŞereflican, Murat
dc.contributor.authorErkoçoğlu, Mustafa
dc.contributor.authorDağlı, Muharrem
dc.contributor.authorTerzi, Elçin Hakan
dc.contributor.authorFırat, Tülin
dc.contributor.authorSeyhan, Sinan
dc.date.accessioned2021-06-23T19:44:40Z
dc.date.available2021-06-23T19:44:40Z
dc.date.issued2016
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground/Aims: In this study, we aimed to evaluate the histopathological effects of thymoquinone treatment of the nasal mucosa in a rabbit model of allergic rhinitis, and we compared its effects with those of nasal mometasone furoate. Methods: A total of 24 male New Zealand rabbits were used. The animals were randomly assigned to one of four groups. Group 1 received no treatment, while group 2 underwent ovalbumin (OVA) sensitization only. Group 3 was the study group; after OVA sensitization, the rabbits were treated with intranasal thymoquinone. The group 4 rabbits received mometasone furoate for 7 days after OVA sensitization. Mucosal structures were stained with hematoxylin and eosin, while toluidine blue was used to stain mast cells. Apoptosis was evaluated using a TUNEL assay. Results: In the positive control groups, including the thymoquinone and intranasal mometasone furoate groups, intraepithelial and submucosal inflammation and goblet cell hypertrophy were significantly decreased compared to group 2 (p < 0.001). The cilial structure was normal, as was the chondrocyte structure in both treatment groups. Conclusion: This is the first study to evaluate the histopathological effects of thymoquinone in an allergic rhinitis model. Thymoquinone reduced allergic inflammation and may be valuable for treating allergic rhinitis. However, additional studies are needed. (C) 2016 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000442353
dc.identifier.endpage60en_US
dc.identifier.issn0301-1569
dc.identifier.issn1423-0275
dc.identifier.issue1en_US
dc.identifier.pmid26828813en_US
dc.identifier.scopus2-s2.0-84957619878en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage55en_US
dc.identifier.urihttps://doi.org/10.1159/000442353
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9025
dc.identifier.volume78en_US
dc.identifier.wosWOS:000371352700008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYurttaş, Veysel
dc.institutionauthorŞereflican, Murat
dc.institutionauthorErkoçoğlu, Mustafa
dc.institutionauthorDağlı, Muharrem
dc.institutionauthorTerzi, Elçin Hakan
dc.institutionauthorFırat, Tülin
dc.institutionauthorSeyhan, Sinan
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofOrl-Journal For Oto-Rhino-Laryngology Head And Neck Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHistopathologyen_US
dc.subjectRhinitisen_US
dc.subjectThymoquinoneen_US
dc.subjectSteroiden_US
dc.subjectNasal Mucosaen_US
dc.titleComparison of histopathological effects of thymoquinone and local nasal corticosteroids in allergic rhinitis in a rabbit modelen_US
dc.typeArticleen_US

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