Effects of Nigella sativa seeds and certain species of fungi extracts on number and activation of dural mast cells in rats

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dc.authorid0000-0002-8212-7149en_US
dc.authorid0000-0001-9261-2634en_US
dc.authorid0000-0002-1668-7850
dc.contributor.authorKılınç, Erkan
dc.contributor.authorDağıstan, Yaşar
dc.contributor.authorKotan, Batuhan
dc.contributor.authorÇetinkaya, Ayhan
dc.date.accessioned2021-06-23T19:48:57Z
dc.date.available2021-06-23T19:48:57Z
dc.date.issued2017
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractIn this study, we aimed to investigate the effects of Nigella sativa seeds and certain species of fungi extracts on the number and degranulation states of dural mast cells in rats. Rats were fed ad libitum with normal tap water or tap water with extract of N. sativa seed, Ramaria condensata, Lactarius salmonicolor, Lactarius piperatus, and Tricholoma terreum for 3 days. Mast cells in dura mater were counted and evaluated in terms of granulation and degranulation states. Compound 48/80, a mast cell degranulating agent, and T. terreum significantly increased the percent of degranulated mast cells in dura mater, respectively (p < 0.01 and p < 0.05). Moreover, T. terreum causes a significant increase in the total number of mast cells (p < 0.05). N. sativa significantly inhibited mast cell degranulation induced by both the compound 48/80 and T. terreum (p < 0.05), and significantly decreased the mast cell numbers increased by T. terreum (p < 0.05). Our results suggested that T. terreum following ingestion can contribute to headaches like migraine via dural mast cell degranulation and N. sativa may be able to exert analgesic and anti-inflammatory effects by stabilizing dural mast cells. However, investigation is needed to determine the ingredients of N. sativa that may be responsible for these beneficial effects.en_US
dc.identifier.doi10.1556/2060.104.2017.1.8
dc.identifier.endpage24en_US
dc.identifier.issn2498-602X
dc.identifier.issue1en_US
dc.identifier.pmid28361577en_US
dc.identifier.scopus2-s2.0-85020390422en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage15en_US
dc.identifier.urihttps://doi.org/10.1556/2060.104.2017.1.8
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9280
dc.identifier.volume104en_US
dc.identifier.wosWOS:000402086800002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKılınç, Erkan
dc.language.isoenen_US
dc.publisherAkademiai Kiado Rten_US
dc.relation.ispartofPhysiology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMigraineen_US
dc.subjectNeurogenic Inflammationen_US
dc.subjectDura Materen_US
dc.subjectMast Cellen_US
dc.subjectNigella Sativaen_US
dc.subjectTricholoma Terreumen_US
dc.titleEffects of Nigella sativa seeds and certain species of fungi extracts on number and activation of dural mast cells in ratsen_US
dc.typeArticleen_US

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