Cervical sympathectomy modulates the neurogenic inflammatory neuropeptides following experimental subarachnoid hemorrhage in rats

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dc.authorid0000-0001-9261-2634en_US
dc.authorid0000-0002-1668-7850
dc.contributor.authorDağıstan, Yaşar
dc.contributor.authorKılınç, Erkan
dc.contributor.authorBalcı, Cemre Nur
dc.date.accessioned2021-06-23T19:50:40Z
dc.date.available2021-06-23T19:50:40Z
dc.date.issued2019
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description15th Pain Congress with International Participation -- NOV 15-18, 2018 -- Antalya, TURKEYen_US
dc.description.abstractBackground: Neuroinflammation is implicated in cerebral vasospasm and brain injuries after subarachnoid hemorrhage (SAH). In addition to classical neuroinflammation with increased inflammatory cytokines, a sterile neurogenic inflammation characterized by release of potent vasoactive neuropeptides may be responsible for brain injuries after SAH. Sympathetic discharges from superior cervical ganglion contribute to vasoconstriction of cerebral arteries Thus, we investigated the effects of surgical cervical sympathectomy on the neurogenic inflammatory neuropeptides shortly after SAH induction in a model of SAH in rats. Methods: Male Wistar rats were divided into 4 groups: control; was not touched, saline group; 300 I of saline was injected into prechiasmatic cistern, SAH + Sham group; 300 mu l of autologous blood was injected to induce subarachnoid hemorrhage into prechiasmatic cistern; SAH + Symp group; the left cervical sympathetic branch was surgically removed after the induction of SAH. Levels of neuropeptides CGRP, SP and VIP which are responsible for neurogenic inflammation, in plasma, trigeminal ganglion, brainstem and brain tissue were measured by ELISA. In addition, c-fos expression as a marker of neuronal activation in the trigeminal nucleus caudalis (TNC) was determined by immunohistochemical staining. Results: SAH significantly increased c-fos expression in the TNC, as well as CGRP, SP and VIP concentrations in plasma and trigeminal ganglion neurons, and also CGRP and SP concentrations in the brainstem. Cervical sympathectomy application significantly reduced the increases in these parameters induced by SAH. Conclusions: Our findings suggest that cervical sympathectomy treatment may prevent early brain injury by modulating SAH-induced neurogenic inflammatory neuropeptides such as CGRP, SP and VIP, and improve the quality of life in survivors following SAH.en_US
dc.identifier.doi10.1016/j.brainres.2019.146366
dc.identifier.issn0006-8993
dc.identifier.issn1872-6240
dc.identifier.pmid31401069en_US
dc.identifier.scopus2-s2.0-85070365620en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2019.146366
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9835
dc.identifier.volume1722en_US
dc.identifier.wosWOS:000491301400020en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDağıstan, Yaşar
dc.institutionauthorKılınç, Erkan
dc.institutionauthorBalcı, Cemre Nur
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofBrain Researchen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSubarachnoid Hemorrhageen_US
dc.subjectCervical Sympathectomyen_US
dc.subjectNeuropeptidesen_US
dc.subjectNeurogenic Inflammationen_US
dc.subjectTrigeminovascular Systemen_US
dc.titleCervical sympathectomy modulates the neurogenic inflammatory neuropeptides following experimental subarachnoid hemorrhage in ratsen_US
dc.typeConference Objecten_US

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