Sağlık Bilimleri Enstitüsü/Diğer Yayınlar Koleksiyonu
Bu koleksiyon için kalıcı URI
Güncel Gönderiler
Öğe Comparison of anxiety levels of hospitalized COVID-19 patients, individuals under quarantine, and individuals in society(WILEY, 2022) Kesgin, Makbule Tokur; Tok, Hümeyra Hançer; Uzun, Lütfiye N.; Pehlivan, ŞenayPurpose: This study aims to compare the anxiety levels of COVID-19 patients, individuals under quarantine, and healthy individuals in society. Design and Methods: This cross-sectional study was conducted from May 25, 2020 to June 25, 2020 in a city located in the northwest of Turkey. The data were collected using a personal information form, the Beck Anxiety Scale, administered in face-to-face interviews, and online questionnaires. The data were analyzed using descriptive statistics, Kruskal-Wallis, Mann-Whitney U, and logistic regression analyses. Findings: The anxiety level of individuals under quarantine (Median: min-max = 1: 0-55) was significantly lower statistically compared to that of the rest of the society (Median: min-max = 6: 0-63) and hospitalized COVID-19 patients (Median: min-max = 5: 0-42) (p = 0.0001). Female gender, being 61 years of age and older, having psychiatric and chronic illnesses, and experiencing disrupted sleep patterns were determined to be the factors associated with high levels of anxiety. Practice Implications: This study found that society in general and hospitalized COVID-19 patients had high anxiety levels. The study results can be useful for creating training and population-based screening programs to control the anxiety of individuals under quarantine, hospitalized COVID-19 patients, and the rest of the society during the pandemic. Additionally, the finding from this study on groups at risk for anxiety will provide important data for future research on this subject and for the planning of health services offered to these groups.Öğe Cervical sympathectomy modulates the neurogenic inflammatory neuropeptides following experimental subarachnoid hemorrhage in rats(Elsevier, 2019) Dağıstan, Yaşar; Kılınç, Erkan; Balcı, Cemre NurBackground: Neuroinflammation is implicated in cerebral vasospasm and brain injuries after subarachnoid hemorrhage (SAH). In addition to classical neuroinflammation with increased inflammatory cytokines, a sterile neurogenic inflammation characterized by release of potent vasoactive neuropeptides may be responsible for brain injuries after SAH. Sympathetic discharges from superior cervical ganglion contribute to vasoconstriction of cerebral arteries Thus, we investigated the effects of surgical cervical sympathectomy on the neurogenic inflammatory neuropeptides shortly after SAH induction in a model of SAH in rats. Methods: Male Wistar rats were divided into 4 groups: control; was not touched, saline group; 300 I of saline was injected into prechiasmatic cistern, SAH + Sham group; 300 mu l of autologous blood was injected to induce subarachnoid hemorrhage into prechiasmatic cistern; SAH + Symp group; the left cervical sympathetic branch was surgically removed after the induction of SAH. Levels of neuropeptides CGRP, SP and VIP which are responsible for neurogenic inflammation, in plasma, trigeminal ganglion, brainstem and brain tissue were measured by ELISA. In addition, c-fos expression as a marker of neuronal activation in the trigeminal nucleus caudalis (TNC) was determined by immunohistochemical staining. Results: SAH significantly increased c-fos expression in the TNC, as well as CGRP, SP and VIP concentrations in plasma and trigeminal ganglion neurons, and also CGRP and SP concentrations in the brainstem. Cervical sympathectomy application significantly reduced the increases in these parameters induced by SAH. Conclusions: Our findings suggest that cervical sympathectomy treatment may prevent early brain injury by modulating SAH-induced neurogenic inflammatory neuropeptides such as CGRP, SP and VIP, and improve the quality of life in survivors following SAH.
