The histopathological and electrophysiological effects of thymoquinone and methylprednisolone in a rabbit traumatic facial nerve paralysis model

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dc.authorid0000-0001-8616-832Xen_US
dc.authorid0000-0002-6223-4254
dc.authorid0000-0002-9647-4432
dc.contributor.authorŞereflican, Murat
dc.contributor.authorYurttaş, Veysel
dc.contributor.authorÖzyalvaçlı, Gülzade
dc.contributor.authorTerzi, Elçin Hakan
dc.contributor.authorTürkoğlu, Şule Aydın
dc.contributor.authorYıldız, Serpil
dc.date.accessioned2021-06-23T19:43:08Z
dc.date.available2021-06-23T19:43:08Z
dc.date.issued2016
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractObjective: We aimed to determine the effects of methylprednisolone and thymoquinone on nerve healing in a traumatic facial nerve paralysis animal model. Subjects and methods: Twenty-four rabbits were randomly divided into 4 groups: group I: control group received no medication and no trauma; group II: sham group received no medication after facial nerve trauma group III: 5 mg/kg/day thymoquinone administered; group IV: 1 mg/kg/day methylprednisolone administered. An initial electrophysiological assessment was performed in all the animals. The buccal branch of the facial nerve was then clipped to form a traumatic facial paralysis model. The drugs were administered for two weeks once a day. At the end of the second month, the electrophysiological assessments were performed and the distal part of the traumatic facial nerve were dissected and examined under light microscopy. Results: Best nerve regeneration was observed in the control and the thymoquinone groups, respectively, whereas the weakest regeneration was determined in the sham group. Thymoquinone and methylprednisolone significantly increased nerve recovery, as measured by histopathological scores and electrophysiological assessment. In the thymoquinone group, due to postoperative amplitude, axon diameter and thickness of myelin sheath values were significantly further increased nerve regeneration compared to that of the methylprednisolone group and these values were dose to those of the values of the control group. Conclusion: Thymoquinone was slightly better than methylprednisolone for functional nerve recovery. The neuroprotective effect of thymoquinone was attributed to its antioxidant and anti-inflammatory effects. Thymoquinone can have a new treatment option to ameliorate the nerve jollity. (C) 2016 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.amjoto.2016.05.006
dc.identifier.endpage415en_US
dc.identifier.issn0196-0709
dc.identifier.issn1532-818X
dc.identifier.issue5en_US
dc.identifier.pmid27311344en_US
dc.identifier.scopus2-s2.0-84989876921en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage407en_US
dc.identifier.urihttps://doi.org/10.1016/j.amjoto.2016.05.006
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8701
dc.identifier.volume37en_US
dc.identifier.wosWOS:000384277600003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorŞereflican, Murat
dc.institutionauthorYurttaş, Veysel
dc.institutionauthorÖzyalvaçlı, Gülzade
dc.institutionauthorTerzi, Elçin Hakan
dc.institutionauthorTürkoğlu, Şule Aydın
dc.institutionauthorYıldız, Serpil
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofAmerican Journal Of Otolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRabbit Traumatic Facial Nerve Paralysisen_US
dc.subjectThymoquinone
dc.subjectMethylprednisol
dc.subjectHistopathological
dc.titleThe histopathological and electrophysiological effects of thymoquinone and methylprednisolone in a rabbit traumatic facial nerve paralysis modelen_US
dc.typeArticleen_US

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