Aqueous humour and serum concentration of asymmetric dimethyl arginine in pseudoexfoliation syndrome

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dc.authorid0000-0002-3156-1076en_US
dc.authorid0000-0002-4060-3354en_US
dc.contributor.authorTosun, Mehmet
dc.contributor.authorErdurmuş, Mesut
dc.contributor.authorBuğdaycı, Güler
dc.contributor.authorÇelebi, Serdal
dc.contributor.authorAlçelik, Aytekin
dc.date.accessioned2021-06-23T19:29:22Z
dc.date.available2021-06-23T19:29:22Z
dc.date.issued2012
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective Asymmetric dimethyl arginine (ADMA) is the major endogenous inhibitor of nitric oxide synthase. ADMA is related to endothelial dysfunction and is an independent cardiovascular risk factor. This study aimed to evaluate the concentration of ADMA in aqueous humour and serum samples of patients with pseudoexfoliation (PEX) syndrome. Materials and Methods 21 cataract patients with PEX syndrome (PEX group) and 18 cataract patients without PEX syndrome (control group) were enrolled in the study. ADMA was measured in the aqueous humour and serum of the PEX and control groups. ELISA was used to determine the ADMA concentration. Results Mean aqueous humour ADMA concentration in the PEX group was 0.39 +/- 0.07 mu mol/l and in the control group was 0.34 +/- 0.06 mu mol/l. Mean serum ADMA concentration in the PEX group was 0.5660.21 mu mol/l and in the control group was 0.4460.12 mu mol/l. ADMA concentration of aqueous humour in the PEX group was significantly higher than the control group (p=0.026). Similarly, ADMA concentration of serum in the PEX group was significantly higher than the control group (p=0.039). Conclusions The findings of the present study could suggest that ADMA might play a role in the aetiopathogenesis of PEX syndrome. Higher aqueous and serum levels of ADMA might be potential evidence of endothelial dysfunction in PEX syndrome.en_US
dc.identifier.doi10.1136/bjophthalmol-2012-301901
dc.identifier.endpage1140en_US
dc.identifier.issn0007-1161
dc.identifier.issue8en_US
dc.identifier.pmid22730511en_US
dc.identifier.scopus2-s2.0-84864856826en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1137en_US
dc.identifier.urihttps://doi.org/10.1136/bjophthalmol-2012-301901
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7161
dc.identifier.volume96en_US
dc.identifier.wosWOS:000306713700020en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTosun, Mehmet
dc.institutionauthorErdurmuş, Mesut
dc.institutionauthorBuğdaycı, Güler
dc.institutionauthorÇelebi, Serdal
dc.institutionauthorAlçelik, Aytekin
dc.language.isoenen_US
dc.publisherBmj Publishing Groupen_US
dc.relation.ispartofBritish Journal Of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPseudoexfoliation Syndromeen_US
dc.titleAqueous humour and serum concentration of asymmetric dimethyl arginine in pseudoexfoliation syndromeen_US
dc.typeArticleen_US

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