Otosclerosis and vitamin D receptor gene polymorphism

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dc.authorid0000-0002-5711-0038
dc.authorid0000-0001-9589-4091
dc.contributor.authorYıldırım, Yavuz Selim
dc.contributor.authorApuhan, Tayfun
dc.contributor.authorDüzenli, Selma
dc.contributor.authorArslan, Ali Osman
dc.date.accessioned2021-06-23T19:34:18Z
dc.date.available2021-06-23T19:34:18Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: The possible genetic relationship between otosclerosis and Vitamin D Receptor (VDR) gene polymorphism is uncertain. The aim of this study is to assess association between otosclerosis and VDR gene polymorphisms. Study Design: Case control Studies. Setting: Tertiary referral center. Subjects and Methods: Clinical diagnosis of stapes fixation was based on otoscopic, audiometric, tympanometric and surgical findings. We identified 25 eligible patient and 60 controls to investigate the association of the VDR gene polymorphisms FokI, BsmI, ApaI, and Tag I with otosclerosis. The patient and control DNA was genotyped for, VDR Bsm I (rs1544410), VDR Apo I (rs7975232), VDR Tag I (rs731236) and VDR Fok I (rs2228570) gene. Primer, simple probe sequences was genotyped by RT-PCR restriction fragment length polymorphism. Results: There was a statistically significant association between VDR gene and otosclerosis in polymorphism Tag I, Apo I and Bsm I. There was no significant association between VDR gene and otosclerosis in polymorphism Fog I. Conclusion: Three polymorphisms (Tag I, Apa I and Bsm I) in the VDR gene appear to be associated to susceptibility to otosclerosis disorder with otosclerosis patients. (C) 2013 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.amjoto.2013.03.016
dc.identifier.endpage457en_US
dc.identifier.issn0196-0709
dc.identifier.issn1532-818X
dc.identifier.issue5en_US
dc.identifier.pmid23639864en_US
dc.identifier.scopus2-s2.0-84883223133en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage454en_US
dc.identifier.urihttps://doi.org/10.1016/j.amjoto.2013.03.016
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7460
dc.identifier.volume34en_US
dc.identifier.wosWOS:000324149400017en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorApuhan, Tayfun
dc.institutionauthorDüzenli, Selma
dc.institutionauthorArslan, Ali Osman
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofAmerican Journal Of Otolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleOtosclerosis and vitamin D receptor gene polymorphismen_US
dc.typeArticleen_US

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