Otosclerosis and vitamin D receptor gene polymorphism
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Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
W B Saunders Co-Elsevier Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: The possible genetic relationship between otosclerosis and Vitamin D Receptor (VDR) gene polymorphism is uncertain. The aim of this study is to assess association between otosclerosis and VDR gene polymorphisms. Study Design: Case control Studies. Setting: Tertiary referral center. Subjects and Methods: Clinical diagnosis of stapes fixation was based on otoscopic, audiometric, tympanometric and surgical findings. We identified 25 eligible patient and 60 controls to investigate the association of the VDR gene polymorphisms FokI, BsmI, ApaI, and Tag I with otosclerosis. The patient and control DNA was genotyped for, VDR Bsm I (rs1544410), VDR Apo I (rs7975232), VDR Tag I (rs731236) and VDR Fok I (rs2228570) gene. Primer, simple probe sequences was genotyped by RT-PCR restriction fragment length polymorphism. Results: There was a statistically significant association between VDR gene and otosclerosis in polymorphism Tag I, Apo I and Bsm I. There was no significant association between VDR gene and otosclerosis in polymorphism Fog I. Conclusion: Three polymorphisms (Tag I, Apa I and Bsm I) in the VDR gene appear to be associated to susceptibility to otosclerosis disorder with otosclerosis patients. (C) 2013 Elsevier Inc. All rights reserved.
Açıklama
Anahtar Kelimeler
Kaynak
American Journal Of Otolaryngology
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
34
Sayı
5
