The effect of risedronate on posterior lateral spinal fusion in a rat model

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dc.authorid0000-0002-5566-2437en_US
dc.authorid0000-0001-5073-0691en_US
dc.authorid0000-0002-0437-5075
dc.authorid0000-0002-2572-0376
dc.authorid0000-0001-7965-6229
dc.contributor.authorGezici, Ali Rıza
dc.contributor.authorErgün, Rüçhan
dc.contributor.authorGürel, Kamil
dc.contributor.authorYılmaz, Fahri
dc.contributor.authorOkay, Önder
dc.contributor.authorBozdoğan, Ömer
dc.date.accessioned2021-06-23T19:26:12Z
dc.date.available2021-06-23T19:26:12Z
dc.date.issued2009
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective : To evaluate the potential effects of risedronate (RIS) which shows a higher anti-resorptive effect among bisphosphonates, after a posterolateral lumbar intertransverse process spinal fusion using both autograft and allograft in a rat model. Methods : A total of 28 Sprague-Dawley rats were randomized into 2 study groups. A posterolateral lumbar intertransverse process spinal fusion was performed using both autograft and allograft in a rat model. Group I (control) received 0.1 mL of steril saline (placebo) and Group II (treatment) received risedronate, equivalent to human dose (10 mu g/kg/week) for 10-weeks period. Results : The fusion rates as determined by manual palpation were 69% in the group I and 46% in the group II (p = 0.251). According to radiographic score, the spinal segment was considered to be fused radiographically in 7 (53%) of the 13 controls and 9 (69%) of the 13 rats treated with RIS (p = 0.851). The mean histological scores were 5.69 +/- 0.13 and 3.84 +/- 0.43 for the control and treatment groups, respectively. There was a significant difference between the both groups (p = 0.001). The mean bone density of the fusion masses was 86.9 +/- 2.34 in the control group and 106.0 +/- 3.54 in the RIS treatment group. There was a statistical difference in mean bone densities of the fusion masses comparing the two groups (p = 0.001). Conclusion : In this study, risedronate appears to delay bone fusion in a rat model. This occurs as a result of uncoupling the balanced osteoclastic and osteoblastic activity inherent to bone healing. These findings suggest that a discontinuation of risedronate postoperatively during acute fusion period may be warranted.en_US
dc.identifier.doi10.3340/jkns.2009.46.1.45
dc.identifier.endpage51en_US
dc.identifier.issn2005-3711
dc.identifier.issn1598-7876
dc.identifier.issue1en_US
dc.identifier.pmid19707493en_US
dc.identifier.scopus2-s2.0-73349083719en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage45en_US
dc.identifier.urihttps://doi.org/10.3340/jkns.2009.46.1.45
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6454
dc.identifier.volume46en_US
dc.identifier.wosWOS:000268967000008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGezici, Ali Rıza
dc.institutionauthorErgün, Rüçhan
dc.institutionauthorGürel, Kamil
dc.institutionauthorYılmaz, Fahri
dc.institutionauthorBozdoğan, Ömer
dc.language.isoenen_US
dc.publisherKorean Neurosurgical Societyen_US
dc.relation.ispartofJournal Of Korean Neurosurgical Societyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRatsen_US
dc.subjectRisedronateen_US
dc.subjectSpinal Fusionen_US
dc.subjectSpineen_US
dc.titleThe effect of risedronate on posterior lateral spinal fusion in a rat modelen_US
dc.typeArticleen_US

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