Erythrocyte reduced/oxidized glutathione and serum thiol/disulfide homeostasis in patients with rheumatoid arthritis

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dc.authorid0000-0003-0434-3206en_US
dc.authorid0000-0003-1856-9513en_US
dc.authorid0000-0002-9163-2569en_US
dc.authorid0000-0001-9263-7209en_US
dc.authorid0000-0002-2996-3236en_US
dc.contributor.authorAlışık, Murat
dc.contributor.authorAlışık, Tuğba
dc.contributor.authorNacır, Barış
dc.contributor.authorNeşelioğlu, Salim
dc.contributor.authorIşık, İrem Genç
dc.contributor.authorKoyuncu, Pınar
dc.contributor.authorErel, Özcan
dc.date.accessioned2023-06-15T07:18:40Z
dc.date.available2023-06-15T07:18:40Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Chronic inflammation and oxidative stress are the most known mechanisms in Rheumatoid Arthritis (RA) pathophysiology, which is still not fully elucidated. In this study, we evaluated oxidative status by determining intracellular reduced/oxidized glutathione (GSH/GSSG) homeostasis and serum thiol/disulfide (SH/SS) homeostasis in RA patients. Methods: A total of 152 RA patient and 89 healthy controls were included in the study. RA patients were subdivided according to disease activity score-28 (DAS-28) as active RA and remission RA. Intracellular GSH/GSSG and serum SH/SS homeostasis parameters were analyzed. Results: Median (1st-3rd quartile values) SS/SH and GSSG/GSH percent ratio levels were significantly higher in RA patients (6.94 (6.02-8.54) and 69.8 (44.05-85.29); respectively) compared to controls (4.62 (4.15-5.46) and 34.9 (22.43-62.2); respectively) (p < 0.05 for all). SS/SH and GSSG/GSH percent ratio levels were significantly higher in active RA patients when compared to remission RA patients and controls (p < 0.05 for all). SS/SH and GSSG/GSH percent ratios were significantly increased in remission RA group compared to controls (p < 0.05 for all). DAS28 scores were positively correlated with SS/SH and GSSG/GSH percent ratios (rho = 0.259 and 0.296; respectively). Conclusions: These findings suggest that active intracellular and extracellular thiol group oxidation process might play a role in RA pathogenesis and further work in these areas may be warranted to show potential value of evaluating intracellular GSSG/GSH and serum SH/SS balances together in disease monitoring.en_US
dc.identifier.citationAlisik, M., Alisik, T., Nacir, B., Neselioglu, S., Genc-Isik, I., Koyuncu, P., & Erel, O. (2021). Erythrocyte reduced/oxidized glutathione and serum thiol/disulfide homeostasis in patients with rheumatoid arthritis. Clinical Biochemistry, 94, 56-61.en_US
dc.identifier.doi10.1016/j.clinbiochem.2021.04.023
dc.identifier.endpage61en_US
dc.identifier.issn0009-9120
dc.identifier.issn1873-2933
dc.identifier.pmid33933432en_US
dc.identifier.scopus2-s2.0-85106665056en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage56en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.clinbiochem.2021.04.023
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11123
dc.identifier.volume94en_US
dc.identifier.wosWOS:000675833600008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAlışık, Murat
dc.institutionauthorAlışık, Tuğba
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofClinical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOxidative Stressen_US
dc.subjectDisease-Activityen_US
dc.titleErythrocyte reduced/oxidized glutathione and serum thiol/disulfide homeostasis in patients with rheumatoid arthritisen_US
dc.typeArticleen_US

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